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Öğe THE IMPACT OF LEPTIN AND ESTRADIOL LEVELS ON CLINICAL OUTCOMES IN METASTATIC BREAST CANCER (MBC) PATIENTS TREATED WITH AROMATASE INHIBITORS (AIS)(OXFORD UNIV PRESS, 2008) Artaç, Mehmet; Samur, Mustafa; Kıyıcı, Aysel; Afacan, Berna; Özdoğan, Mustafa; Bozcuk, Hakan[Abstract not Available]Öğe The impact of waist-to-hip ratio (WHR) on survival in metastatic breast cancer patients treated with aromatase inhibitors (AIs)(AMER SOC CLINICAL ONCOLOGY, 2007) Artaç, Mehmet; Samur, Mustafa; Bozcuk, Hakan; Afacan, Berna; Özdoğan, Mustafa[Abstract not Available]Öğe The impact of waist-to-hip ratio on clinical outcomes in metastatic breast cancer patients treated with aromatase inhibitors(Churchill Livingstone, 2008) Artaç, Mehmet; Bozcuk, Hakan; Afacan, Berna; Özdoğan, Mustafa; Samur, MustafaWe aimed to identify whether abdominal fat distribution could affect the outcome in metastatic breast cancer (MBC) patients treated with aromatase inhibitors (AIs) or not. A total of 42 MBC patients treated with first line hormonal therapy were enrolled in this study. Factors associated with overall survival in the univariate analysis were age, c-erb-B2 expression intensity (+++ versus others by immunohistochemistry), and WHR, whereas only WHR retained significance in the multivariate analysis. Median overall survival figures were 472 days versus unreached for patients with a WHR of <0.92 and ?0.92 (Log rank statistic = 9.76, P = 0.002). Similarly, the corresponding progression free survival figures for patients with a WHR of <0.92 and ?0.92 were 423 versus 1004 days (Log rank statistic = 6.37, P = 0.012). This study suggests that WHR may serve as a potential predictive marker in MBC patients treated with AIs. © 2008 Elsevier Ltd. All rights reserved.
