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    The efficacy of intrathecal administration of a very low dose potirelin after acute spinal cord injury
    (ELSEVIER SCI LTD, 2008) Cengiz, Sahika Liva; Ustun, Mehmet Erkan; Topcu, Cemile; Ahmet, A. K.
    Background and object: The objective of this study was to determine the effect of a very tow dose protirelin in cerebrospinal fluid (CSF) glucose, magnesium and lactate levels after spinal cord trauma (SCT) in rabbits. We also aimed to evaluate whether this very tow dose might induce analeptic effect. Material and methods: Twenty rabbits were divided equally into two groups: group I (n = 10) was the control group, suffered from SCT but received only saline after SCT. Group II (n = 10) (treatment group), received a very low dose of 0.05 mg/kg thyrotropin releasing hormone (TRH), analogue protirelin intrathecally after SCT. The basal CSF glucose, magnesium and lactate levels were recorded in both groups. CSF lactate, glucose and magnesium contents were recorded at the same time (an hour before and after) SCT Serum thyroid stimulating hormone (TSH), freetriiodothyronine (73) and freethyroxine (FT4) were measured in all rabbits before and after SCT. Results: Before spinal cord trauma, there were not any significant differences in glucose, lactate and magnesium Levels between group I and II whereas, after spinal cord trauma in group 11, the significant suppression in elevation of Lactate and glucose depletion (p < 0.05) were observed white no significant suppression was observed in magnesium level (p > 0.05) as compared with group I (Table 3). In respect of serum TSH levels, there were not any significant differences between two groups before and after SCT. Conclusions: This study showed that intrathecal TRH has no analeptic effect on serum TSH, FT3 and FT4 levels but can attenuate the increase of lactate levels following spinal cord trauma. No significant decrease in magnesium level and also suppression of glucose decline in group II, may be related to the neuroprotective effects of TRH. (C) 2008 Published by Elsevier Ltd.
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    Succesful treatment of prolonged sulfonylurea-induced hypoglycemia with octreotide in a patient with chronic renal failure: Case report
    (ORTADOGU AD PRES & PUBL CO, 2008) Guel, Mehmet; Cander, Basar; Ahmet, A. K.; Girisgin, A. Sadik; Bayir, Ayseguel; Kocak, Sedat
    Patients who present to the emergency department after ingestion of excessive amounts of suflonylurea medications have hypoglycemia refractory to dextrose administration. Recently, the use of octreotide was described as an alternative treatment in such patients. A diabetic patient with chronic renal failure who ingested excessive amounts of sulfonylurea medications causing refractory hypoglycemia resistant to treatment with large doses of intravenous dextrose was presented here. Octreotide administration rapidly reversed hypoglycemia allowing the patient's stabilization and eventual discharge without any significant adverse events. We believe that octreotide may be an effective therapy in refractory sulfonylurea-induced hypoglycemia.