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Öğe The effects of CoQ10 on the erythrocyte and liver tissue cholinesterase, NO and MDA levels in the acute organophosphate toxicity(ELSEVIER IRELAND LTD, 2011) Bayir, A.; Kara, H.; Koylu, O.; Kocabas, R.; Ak, A.[Abstract not Available]Öğe Effects of Deferoxamine on Tissue Lactate and Malondialdehyde Levels in Cerebral Ischemia(Prous Science, Sa , 2003) Barışkaner, Hülagü; Üstün, M. E.; Ak, A.; Yosunkaya, Alper; Doğan, N.; Gürbilek, MehmetIn the present study, the effects of deferoxamine on tissue lactate and malondialdehyde (MDA) levels after cerebral ischemia at rabbits was studied. Rabbits were divided equally, into three groups: group 1: sham-operated group; group 2: cerebral ischemia produced by clamping bilateral common carotid arteries for 60 min: and group 3: deferoxamine 100 mg/kg i.v administered within 5 min after opening the clamps. EEG recordings were obtained in all groups before clamping and in group 2 and 3 60 min after clamping and 60 min after opening the clamps. One hour after opening the clamps and taking EEG recordings, brain cortices were resected and the concentrations of lactate and MDA were determined using the spectrophotometric enzymatic and thiobarbituric acid methods, respectively. There were significant differences between group I and the other groups in MDA and lactate levels (p < 0.05). There were no significant differences in lactate levels between groups 2 and 3. Preischemic EEG grades were the same at till groups. Preischemic (aid postischemic EEG values were significantly different (p < 0.05), but there were no significant differences between postischemic EEG grades in groups 2 and 3. There was also a correlation between postischemic EEG grades and lactate levels, but no correlation between postischemic EEG grades and MDA levels. These results demonstrate that cerebral ischemia leads to an increase in brain tissue lactate and MDA levels and deferoxamine suppresses the increase of MDA, but not lactate. Deferoxamine treatment caused no significant EEG changes. EEG grades correlated well with lactate levels.Öğe Effects of Magnesium Sulfate on Tissue Lactate and Malondialdehyde Levels After Cerebral Ischemia(Karger, 2003) Barışkaner, Hülagü; Üstün, M. E.; Ak, A.; Yosunkaya, Alper; Ulusoy, H. B.; Gürbilek, MehmetIn the present study, the effects of magnesium sulfate on tissue lactate and malondialdehyde (MIDA) levels after cerebral ischemia in rabbits were studied. The rabbits were divided equally into three groups. Group 1 (n = 8) was the sham-operated control group, in group 2 (n = 8) only cerebral ischemia was induced by clamping bilaterally the common carotid arteries for 60 min, and in group 3 (n = 8) magnesium sulfate was administered at a dose of 100 mg/kg im. within 5 min after opening the clamps. In group 1 EEG recordings were obtained immediately and 60 and 120 min after craniectomy. In groups 2 and 3 EEG recordings were obtained immediately after craniectomy but before clamping and 60 min after clamping. One hour after opening the clamps and taking EEG recordings, brain cortices were resected, and the concentrations of lactate and MIDA were determined using spectrophotometric/enzymatic and thiobarbituric acid methods, respectively. In all groups, there were significant differences between MDA and lactate levels (p < 0.05). There were no significant differences in lactate levels between groups 2 and 3 (p > 0.05), and also the preischemic EEG grades were the same in all groups. Preischemic and postischemic EEG values were significantly different (p < 0.05), and there were also significant differences between postischemic EEG grades in groups 2 and 3 (p < 0.05). There was a correlation between postischemic EEG grades and MIDA and lactate levels. These results demonstrate that cerebral ischemia-reperfusion injury leads to an increase in brain tissue lactate and MIDA levels, that magnesium sulfate suppresses the increase of MDA and lactate concentrations, and that magnesium sulfate, treatment improves the EEG changes. The EEG grades correlated well with MIDA and lactate levels.Öğe The effects of melatonin on erythrocyte and brain cholinesterase, nitric oxide and MDA levels in acute organophosphate toxicity(ELSEVIER IRELAND LTD, 2011) Bayir, A.; Kara, H.; Koylu, O.; Kocabas, R.; Ak, A.[Abstract not Available]Öğe The effects of melatonin on erythrocyte and renal tissue cholinesterase, nitric oxide and MDA levels in acute organophosphate toxicity(ELSEVIER IRELAND LTD, 2011) Bayir, A.; Kara, H.; Koylu, O.; Kocabas, R.; Ak, A.[Abstract not Available]Öğe The effects of N-acetylcysteine on the erythrocyte and lung tissue cholinesterase, nitric oxide and malondialdehyde levels in acute organophosphate toxicity(ELSEVIER IRELAND LTD, 2011) Bayir, A.; Kara, H.; Koylu, O.; Kocabas, R.; Ak, A.[Abstract not Available]Öğe Effects of Nimodipine on Tissue Lactate and Malondialdehyde Levels in Experimental Head Trauma(2001) Ak, A.; Üstün, M. E.; Öğün, C. Ö.; Duman, A.; Bor, M. A.We studied the effects of nimodipine on brain tissue lactate and malondialdehyde (MDA) levels one hour after experimental head trauma in 25 New Zealand rabbits. Group 1 (n=5) was the sham operated group. Group 2 (n = 10) received head trauma without treatment and in group 3 (n=10) nimodipine was administered for 30 minutes intravenously (2 ?g/kg/min) immediately after head trauma. In groups 2 and 3, tissue samples from the non-traumatized side was named as "a" and traumatized side as "b". The lactate and malondialdehyde contents were significantly higher in groups 2a, 2b, 3a and 3b when compared with to group 1 (P<0.05). The differences between non-treated groups (2a, 2b) and nimodipine treated groups (3a, 3b) were not significant (P>0.05). The differences between the traumatized sides (2b, 3b) and non-traumatized sides (2a, 3a) were significant (P<0.05). These results demonstrated that nimodipine is ineffective in suppressing the increase of tissue lactate and malondialdehyde levels in the early period of experimental head trauma.Öğe Effects of Nimodipine on Tissue Lactate and Malondialdeyde Levels in Experimental Head Trauma(Australian Soc Anaesthetists, 2001) Ak, A.; Üstün, M. E.; Ogün, C. O.; Duman, A.; Bor, M. A.We studied the effects of nimodipine on brain tissue lactate and malondialdehyde (MDA) levels one hour after experimental head trauma in 25 New Zealand rabbits. Group 1(n=5) was the sham operated group. Group 2 (n=10) received head trauma without treatment and in group 3 (n=10) nimodipine was administered for 30 minutes intravenously (2 mug/kg/min) immediately after head trauma. In groups 2 and 3, tissue samples from the nontraumatized side was named as "a" and traumatized side as "b". The lactate and malondialdehyde contents were significantly higher in groups 2a, 2b, 3a and 3b when compared with to group 1 (P <0.05). The differences between non-treated groups (2a, 2b) and nimodipine treated groups (3a, 3b) were not significant (P >0.05). The differences between the traumatized sides (2b, 3b) and non-traumatized sides (2a, 3a) were significant (P <0.05). These results demonstrated that nimodipine is ineffective in suppressing the increase of tissue lactate and malondialdehyde levels in the early period of experimental head trauma.Öğe The effects of ubiquinone (CoQ10) on heart tissue in cardiac toxicity related to organophosphate poisoning(SAGE PUBLICATIONS LTD, 2013) Bayir, A.; Kara, H.; Koylu, O.; Kocabas, R.; Ak, A.The aim of this study was to examine the effects of ubiquinone (CoQ10) on heart tissue and erythrocytes in acute organophosphate poisoning (AOP). A total of 20 rabbits were divided into three groups: sham (n = 8), pralidoxime (PAM) + atropine (n = 6), and CoQ10 + PAM + atropine (n = 6). Blood samples were taken from each test subject to measure the values of acetylcholinesterase (AChE), nitric oxide (NO), and malondialdehyde (MDA) in the plasma and erythrocyte before administration of 50 mg/kg dichlorvos by orogastric tube. Blood samples were then taken at 1, 12, and 24 h post-dichlorvos to determine plasma and erythrocyte levels of AChE, NO, and MDA. Sham group received no treatment. PAM + atropine group received 0.05 mg/kg atropine with repeated doses and PAM: first a 30-mg/kg intravenous (IV) bolus, then a 15-mg/kg IV bolus every 4 h. CoQ10 + PAM + atropine group received same dose PAM and atropine and a 50-mg bolus of IV CoQ10. Thoracotomy was performed in all the animals 24 h after poisoning and then heart tissue samples were obtained. At 12 and 24 h, erythrocyte AChE levels in the CoQ10 animals were considerably higher than those in PAM + atropine animals (p = 0.023 and 0.017, respectively). At 12 and 24 h, erythrocyte MDA and NO levels in CoQ10 animals were significantly lower than those in PAM + atropine animals (p < 0.05). Heart tissue AChE levels in CoQ10 animals were considerably higher than those of the sham and PAM + atropine animals (p = 0.001). Heart tissue MDA and NO levels of CoQ10 animals were significantly lower than those of the sham and PAM + atropine animals (p < 0.01). Treatment of AOP with CoQ10 + PAM + atropine in this animal model had a beneficial effect on both erythrocyte and heart tissue lipid peroxidation and AChE activity.Öğe The effects of vitamin E on the erythrocyte and heart tissue cholinesterase, NO and MDA levels in the acute organophosphate toxicity(ELSEVIER IRELAND LTD, 2011) Bayir, A.; Kara, H.; Koylu, O.; Kocabas, R.; Ak, A.[Abstract not Available]Öğe Pulmonary embolism severity index, age-based markers and evaluation in the emergency department(MANEY PUBLISHING, 2015) Kara, H.; Degirmenci, S.; Bayir, A.; Ak, A.Objectives: The purpose of this study was to assess the severity of pulmonary embolism in the emergency department using vital signs and age-based vital parameters and compare these parameters with pulmonary embolism severity index (PESI) score. Methods: Between January 2011 and October 2014, there were 284 patients diagnosed with pulmonary embolism in the Emergency Unit of Selcuk University Hospital. Patient records were reviewed retrospectively. The PESI scores were calculated, and patients were divided into high-and low-risk groups. Shock index (SI), age-based shock index (SIA), maximum heart rate (MHR), minpulse (MP) and pulse maximum index (PMI) were calculated. The association of these parameters with PESI was evaluated. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the association of risk and mortality with age-based markers. Results: There were 75 men (43%) in the 173 patients included in the study. The PESI classification showed 54 patients in the low-risk group and 119 patients in the high-risk group. Mortality was higher in the PESI high-risk group, and no deaths occurred in the low-risk group. Comparison of the age-based markers and PESI for patients who died or survived showed that AUC for PESI was 0.807, AUC for SI was 0.824 and AUC for SIA was 0.825. Conclusions: The SIA risk classification was more efficient than SI in pulmonary embolism patients who presented to the emergency unit. The SIA was more accurate than SI or PESI in predicting mortality.
