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    The effectiveness of neutrophil-to-lymphocyte ratio for predicting prognosis of idiopathic sudden hearing loss
    (ROYAL BELGIAN SOC EAR, NOSE, THROAT, HEAD & NECK SURGERY, 2018) Ulusoy, Bülent; Bozdemir, K.; Akyol, Mesut; Mise, H., I; Kutluhan, A.; Korkmaz, M. Hakan
    The effectiveness of neutrophil-to-lymphocyte ratio for predicting prognosis of idiopathic sudden hearing loss. Objectives: Here we investigate the relationship between idiopathic sudden hearing loss and neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), mean platelet volume (MPV). and platelet distribution width (PDW), and assess the significance of these markers in predicting response to treatment. Materials and methods: 45 patients and 23 healthy volunteers were included in this retrospective study. Patients were between 18 and 65 years old, diagnosed with idiopathic sudden hearing loss, under the same treatment, and were classified as recovered or unrecovered at the end of treatment. NLR, MPV, PDW and PLR values were determined from complete blood count (CBC) examinations and compared across groups. Results: NLR in the unrecovered group was significantly higher than in the recovered group (Z=2.157; p<0.05), and NLR could be used to predict recovery, as determined by Receiver operating characteristic (ROC) analysis (AUC=0.688, p=0.031, AUC 95% confidence interval: 0.532 - 0.844). MPV was significantly higher in the unrecovered group (F=4.814, p<0.05). Conclusion: NLR and MPV markers can predict prognosis for patients with sudden hearing loss.
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    Insufficiency of positive airway pressure treatment on increased mean platelet volume: a prospective controlled study in patients with obstructive sleep apnea syndrome
    (Springer Verlag, 2019) Ulusoy, Bülent; Oğuzhan, Tolga; Akyol, Mesut; Bozdemir, Kazım; Çiftçi, Bülent; Korkmaz, Mehmet Hakan
    Background: To analyze the association between obstructive sleep apnea syndrome (OSAS) and some hematological variables such as mean platelet volume (MPV), platelet distribution width (PDW), and the impact of positive airway pressure (PAP) treatment on these parameters. Methods: The participants of the present prospective study consist of 36 OSAS patients diagnosed with polysomnography and recommended PAP treatment and 30 healthy members as the control group. Complete blood analyses were conducted to the patient group twice; before the initiation of the PAP treatment and 1 month after regular PAP use. The control group was administered a complete blood analyses only once. Patient and control group were compared in terms of various parameters such as MPV, PDW, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), white blood cell (WBC) values, and platelet counts. Results: MPV value of the patient group was before and after PAP treatment significantly higher than the control group (respectively; Z = 2.246; p = 0.025, and Z = 2.033; p = 0.042). However, there were no statistically significant differences in the values before and after PAP treatment in the patient group (Z = 0.727; p = 0.467). In terms of platelet numbers and PDW values, no significant differences were determined (p > 0.05). Conclusion: MPV value was significantly elevated in OSAS patients. However, the 1 month of PAP treatment was insufficient in decreasing elevated MPV values. © 2019, Springer Nature Switzerland AG.