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    Analysis of Publications on Psoriasis and Tuberculosis
    (Selçuk Üniversitesi, 2024 Şubat) Şahinoğlu, Mustafa Serhat; Şahinoğlu, İrem; Alkan, Sevil
    ABSTRACT Background: Psoriasis is a relatively common inflammatory disease globally with systemic implications and the treatment of psoriasis has advanced rapidly in recent years. However, current treatments, especially anti-tumor necrosis factor (TNF) treatments, can lead to tuberculosis. Objectives: This study’s objective was to analyze tuberculosis and psoriasis-related literature that was published between 1970 and 2021 by using scientometric techniques. Methods: In this bibliometric analysis study, the Web of Science database was used to find the articles on psoriasis and tuberculosis that were published between 1970 and 2021. The VOSviewer software program was used to generate visualization knowledge maps including co-citation, coauthorship, co-occurrence and keyword analysis. Results: A total of 127 documents in the field of psoriasis and tuberculosis were indexed in the Web of Science database. The first reports were in 1971, but until 2004 there was no other publications. Since 2010 the number of publications has begun to increase. While most of the publications were articles (49.606%), 91.339% of them were published in Science Citation Index Expanded journals. 576 authors contributed to psoriasis and tuberculosis literature from 36 countries. The United States (n=26), Italy (n=21), Spain (n=12) were the first 3 countries in the number of publications. Most of the articles were from Dermatology (n=93, 73%) and Rheumatology (n=11, 9%) research areas. Conclusion: As can be understood from this current study on psoriasis and tuberculosis, it has become more popular, especially with anti-TNF treatments. This study recommends focusing more on tuberculosis, especially in psoriasis and psoriatic arthritis patients receiving anti-TNF therapy.
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    Investigation of Thromboembolic Events in COVID-19 Infected Patients
    (Selçuk Üniversitesi, 2023 Şubat) Şahin, Serpil; Altınışık, Hatice Betül; Alkan, Sevil; Küçük, Uğur; Çinpolat, Havva Yasemin; Gönlügür, Uğur
    Aim: The objective of this study was to determine the patient characteristics and clinical outcomes of COVID-19 patients who experienced a thromboembolic event (TEE) and the frequency of this complication. Materials and Methods: Between January 2020 and December 2021, all the patients with positive COVID-19 PCR test results were enrolled in this study. The data of the cases that developed TEE with the diagnosis of COVID-19 were evaluated retrospectively. Results: During the study period, a total of 2,845 patients were hospitalized with a diagnosis of COVID-19. Among this group, 96 patients (3.37%) had TEE associated with COVID-19. The mean age was 63.76 ±13.85 years (range: 28-80 years), with 46 males (4.92%) and 50 females (52.08%). Of these patients, 46 (47.92%) had severe COVID-19 and 50 (52.08%) had only mild respiratory symptoms. Patients in the severe COVID-19 group were older, but there was no statistical significance between the groups. The peripheral venous disease was more common in the mild COVID-19 group while the peripheral arterial disease was more common in the severe COVID-19 group. CRP, uric acid, troponin, creatinine, D-dimer, and leukocyte levels were higher in severe COVID-19 patients with TEE (p<0.05). 81 of 96 patients (84.37%) had the peripheral venous disease, 5 of 96 patients (5.2%) had peripheral arterial disease and 11 of 96 patients (11.45%) had a pulmonary embolism. One patient (1.04%) had both peripheral venous disease and pulmonary embolism. The overall mortality rate was 6.25% (6/96). Conclusions: The thrombotic process associated with COVID-19 affects venous structures more frequently than arteries. Given the significant risk observed for TEE in COVID-19, diagnostic imaging for TEE should be considered with a high degree of clinical suspicion.