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    Evaluation of Relationship Between Serum Neopterin, Cystatin C and Coronary Heart Disease
    (DERMAN MEDICAL PUBL, 2016) Abuşoğlu, Sedat; Toklu, Oğuzhan; Çelik, Hüseyin Tuğrul; Akgöl, Evren; Ellidağ, Hamit Yaşar; Arslan, Banu; Yeşil, Murat
    Aim: It has been reported that neopterin, a key molecule for immun response organization, is released from active macrophages of atheromatous plaque and useful for cardiovascular risk stratification. The aim of this study was to investigate serum cystatin C and neopterin levels in patients with coronary artery disease and examine the relationship between these markers and cardiovascular risk factors. Material and Method: Coronary artery disease group and control group consisted of 75 subjects (61 males, 14 females, mean age 60.5-1 and 50 subjects (25 males, 25 females, mean age 56.9-10), respectively. Results: Serum neopterin concentrations were higher in coronary artery disease group compared to control group, A negative correlation was established between neopterin and high density lipoprotein cholesterol. Also, there was a positive correlation between Gensini score and cystatin C and neopterin. Discussion: Serum cystatin C and neopterin concentrations might be useful markers for determining the coronary artery disease's severity, According to this study, neopterin seems to be a stronger indicator of cardiovascular diseases compared to cystatin C. The positive correlation between Gensini score and the biochemical markers offers us a potential use of these markers in evaluating the disease's severity.