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    Clinical and laboratory features in pediatric patients with common variable immunodeficiency [De?işken immün yetersizlikli çocuk hastalarda klinik ve laboratuvar özellikler]
    (Kare Publishing, 2007) Artaç H.; Keleş S.; Kara R.; Reisli I.
    Aim: Common variable immunodeficiency (CVID) is a primary immunodeficiency disease characterized by defective antibody production and heterogeneous clinical features. We aimed to describe clinical and laboratory features of our patients with CVID. Materail and Method: We restrospectively evaluated the records of children diagnosed with CVID from February 2002 to June 2006 and followed-up for a mean of 29.7±17.4 (2-51) months. Results: A total of 10 patients, 7 females and 3 males (mean age: 9.4±5.1, ranging from 3 to 18) were included in this study. All of them were admitted to our clinic due to recurrent bronchopneumonia. Nine patients had chronic pulmonary disease at the time of CVID diagnosis and lobectomy had been performed in three patients. Serum IgG concentrations were less than 200 mg/dl in four patients. There was a reduction of at least two serum immunoglobulin levels in six patients. Four patients had normal IgG levels, but two of them had decreased IgM levels and the other two had decreased IgA levels. The percentages of B cells was found to be low (%1.6-8.9; 5.3±2.8) in all of the patients. The inversion in the CD4/CD8 ratio was observed in the peripheral blood lymphocytes of eight patients. Conclusions: We suggested that CVID should be especially investigated in patients with chronic pulmonary disease.
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    Iatrogenic Vitamin D Intoxiciation in Infancy: Three Cases
    (2007) Ünal E.; Köksal Y.; Keleş S.; Artaç H.; Reisli İ.; Energin V. M.
    The potential hazards of excessive administration of vitamin D are well known. The increased intestinal absorption of calcium due to vitamin D over dosage leads to hypercalcemia and hypercalciuria that may give rise to the development of nephrocalcinosis, urolithiasis, and soft tissue calcification. Clinical features of three cases of iatrogenic vitamin D intoxication with different radiological findings were presented. The dose of vitamin D should be carefully determined in order to avoid vitamin D intoxication, and its complications. In addition, public health measures should be undertaken to prevent drug consumption without prescription that may be dangerous especially for children.