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Öğe Course of obsessive-compulsive disorder during early postpartum period: a prospective analysis of 16 cases(W B SAUNDERS CO-ELSEVIER INC, 2007) Uguz, Faruk; Gezginc, Kazim; Zeytinci, Ismet Esra; Karatayli, Savas; Askin, Rustem; Guler, Ozkan; Sahin, Figen KirObjective: The aim of the current study was to prospectively examine a course of obsessive-compulsive disorder (OCD) during the early postpartum period. Method: The study data were collected from 16 pregnant women. with a diagnosis of OCD according to the Structured Clinical Interview for DSM-IV (SCID-I). Obsessive-compulsive disorder symptoms were assessed by the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) before and after childbirth. Psychopharmacologic or psychotherapeutic treatments were not administered over the study period. Results: Scores of the mean Y-BOCS-total and Y-BOCS-obsession were significantly reduced from the basal levels to 6 weeks postnatally. No significant difference was found in terms of Y-BOCS-compulsion between 2 interviews. During the study period, whereas the Y-BOCS-total scores were decreased by at least 25% in 8 (50.0%) of 16 patients, only 1 (6.2%) of 16 patients experienced at least a 25% increase in the same scores. Conclusion: The results from a small patient group suggest that some patients may experience a marked improvement in preexisting OCD symptoms after childbirth. (c) 2007 Elsevier Inc. All rights reserved.Öğe Longitudinal assessment of symptom and subtype categories in obsessive-compulsive disorder(WILEY-LISS, 2007) Besiroglu, Lutfullah; Uguz, Faruk; Ozbebit, Ozgur; Guler, Ozkan; Cilli, Ali Savas; Askin, RustemAlthough it has been postulated that symptom subtypes are potential predictors of treatment response, few data exist on the longitudinal course of symptom and subtype categories in obsessive-compulsive disorder (OCD). Putative subtypes of OCD have gradually gained more recognition, but as yet there is no generally accepted subtype discrimination. Subtypes, it has been suggested, could perhaps be discriminated based on autogenous versus reactive obsessions stemming from different cognitive processes. In this study, our aim was to assess whether symptom and subtype categories change over time. Using the Yale-Brown Obsessive Compulsive Symptom Checklist (Y-BOCS-SC), we assessed 109 patients who met DSM-IV criteria for OCD to establish baseline values, then reassessed 91 (83%) of the initial group after 36 +/- 8.2 months. Upon reassessment, we found significant changes from baseline within aggressive, contamination, religious, symmetry and miscellaneous obsessions and within checking, washing, repeating, counting and ordering compulsion categories. Sexual, hoarding, and somatic obsessions, and hoarding and miscellaneous compulsions, did not change significantly. In accordance with the relevant literature, we also assigned patients to one of three subtypes-autogenous, reactive, or mixed groups. Though some changes in subtype categories were found, no subtype shifts (e.g., autogenous to reactive or reactive to autogenous) were observed during the course of the study. Significantly more patients in the autogenous group did not meet OCD criteria at follow-up than did patients in the other groups. Our results suggest that the discrimination between these two types of obsession might be highly valid, because autogenous and reactive obsessions are quite different, both in the development and maintenance of their cognitive mechanisms, and in their outcome.Öğe Obsessive-compulsive disorder in pregnant women during the third trimester of pregnancy(W B SAUNDERS CO-ELSEVIER INC, 2007) Uguz, Faruk; Gezginc, Kazim; Zeytinci, Ismet Esra; Karatayli, Savas; Askin, Rustem; Guler, Ozkan; Sahin, Figen KirObjective: The principal aims of this study were to examine the current prevalence rate, clinical characteristics, and related factors of obsessive -compulsive disorder (OCD) in pregnant women during the third trimester of pregnancy. Method: The study data were gathered from 434 consecutive women in the third trimester of pregnancy who presented to the obstetric outpatient clinics of 2 university research centers and from 58 consecutive nonpregnant women with diagnosed with OCD who presented to the psychiatric outpatient clinics of the same centers. Obsessive-compulsive disorder was diagnosed by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The Yale-Brown Obsessive-Compulsive Scale was used to determine the severity and types of obsessions and compulsions. Results: The prevalence rate of OCD was found to be 3.5% among the women in the third trimester of pregnancy. Two (0.5%) women reported that OCD developed during the second trimester (16th and 24th gestational weeks) of pregnancy. The most common obsessions were contamination (80.0%) and symmetry/exactness (60.0%), whereas the most common compulsions were cleaning/washing (86.7%) and checking (60.0%). Women with pregnancy-onset OCD and some women with previous diagnoses of OCD had obsessions and compulsions with themes focused on the fetus or newborn. Pregnant women with OCD had higher frequencies of family history of OCD compared with women without this disorder. Age, educational level, employment status, number of gestations and live births, history of abortion, frequency of primigravida, and the existence of gestational complications were unrelated to OCD in the pregnant women. Pregnant and nonpregnant 9 women with OCD had similar characteristics of obsessive-compulsive symptoms. Conclusion: Our study suggests that OCD is present relatively frequently among pregnant women during the third trimester of pregnancy, and it has similar clinical features during gestation and nongestation. (C) 2007 Elsevier Inc. All rights reserved.