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Öğe Al-Awadi/Raas-Rothschild syndrome in a newborn with additional anomalies(2010) Alp, E.; Alp, H.; Atabek, M. E.; Pirgon, Ö.Al-Awadi/Raas-Rothschild (AARR) syndrome is a rare phocomelia syndrome characterized by limb/pelvic hypoplasia/aplasia, renal anomalies such as horseshoe and polycystic kidney, and abnormal facial features including cleft palate, hypertelorism and micro-retrognatia. Autosomal recessive inheritance has been proposed for AARR syndrome. In this report a boy affected with AARR syndrome is presented. The previous pregnancy of the mother was terminated because of lower limb agenesis detected at 14 th week of gestation. This report emphasizes the importance of recognizing severe pelvic and limb deficiencies in newborns with AARR syndrome and differentiating the syndrome from other multiple malformation syndromes. Fetal ultrasonography at 15 th week of gestation is helpful in diagnosing the major extremity anomalies in the fetus. © Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing.Öğe Assessment of abnormal glucose homeostasis and insulin resistance in Turkish obese children and adolescents(WILEY, 2007) Atabek, M. E.; Pirgon, O.; Kurtoglu, S.Background: The worldwide increase in the prevalence of childhood obesity is reaching epidemic proportions and is associated with a dramatic rise in cases of type 2 diabetes. We determined the prevalence of impaired glucose regulation and insulin resistance in obese children and adolescents. Methods: A total of 196 obese children [SD score (SDS) of body mass index (BMI): 2.17 +/- 0.03], aged 7-18 years, including 86 male subjects, underwent an oral glucose tolerance test (1.75 g glucose/kg body weight). We used the modified WHO criteria adapted for children for abnormal glucose homeostasis. Homeostasis model assessment was used to estimate insulin resistance in all subjects. The insulin sensitivity index was also determined in subjects. Results: Of the total of 196 obese children, 15 (6.6%) had an abnormal fasting glucose level. Of the 196 obese children, 35 (18%) had impaired glucose tolerance (IGT) and 83 (43%) had insulin resistance. Of the 196 obese children were six (3%) diagnosed with type 2 diabetes. Insulin resistance indices were correlated well with the degree of abnormal glucose tolerance. Conclusions: IGT, insulin resistance and type 2 diabetes are far more common in obese Turkish children than previously thought. Early treatment in obese children and adolescents with IGT constitutes a strategy of reversing the progression to beta-cell failure and preventing type 2 diabetes.Öğe Evidence for an Association Between Type 1 Diabetes and Premature Carotid Atherosclerosis in Childhood(Springer, 2006) Atabek, M. E.; Pirgon, O.; Kurtoglu, S.; İmamoğlu, H.Acute phase proteins have been suggested to be increased in patients with type 1 diabetes. The aim of this study was to evaluate the relationship between serum C-reactive protein (CRP) and intima-media thickness (IMT) and functions of the common carotid artery (CCA) in children and adolescents with type 1 diabetes. Serum CRP levels were measured in 65 children and adolescents with diabetes (33 girls and 32 boys; mean age, 12.7 +/- 3.8 years; range, 7-18; duration of diabetes, 6.9 +/- 3.6 years). Age and diabetes duration, as well as major cardiovascular risk factors including anthropometric and metabolic parameters, were matched between girls and boys. The relations of serum CRP levels to CCA structure and functions were measured by ultrasonography as IMT, cross-sectional compliance, cross-sectional distensibility, diastolic wall stress (DWS), and incremental elastic modulus (IEM). There was no significant difference for serum CRP levels between girls and boys (3.7 +/- 1.3 vs 3.2 +/- 0.4 mg/L; p > 0.05). CRP was positively correlated with IMT (r = 0.49, p = 0.001), IEM (r = 0.24, p = 0.05), DWS (r = 0.58, p < 0.001), and body mass index (BMI) (r = 0.28, p = 0.05). In a multivariate regression model, we included CRP and metabolic and anthropometric parameters such as duration of diabetes, HbA1c, BMI, waist:hip ratio, age, and systolic and diastolic blood pressure as independent variables in the model for CCA structure and functions. CRP emerged as an independent correlation for mean IMT (beta = 0.51, p < 0.001) and DWS (beta = 0.61, p < 0.001). According to our findings, CRP was associated with CCA structure and functions in children and adolescents with type 1 diabetes.Öğe Konya Yöresindeki Çocuklarda Hepatit B ve C Seroprevalansı(2000) Atabek, M. E.; Ural, O.; Çoban, H.; Atabek, M. N.; Karaeren, Z.; Aydın, K.; Erkul, İ.Amaç: Konya yöresindeki çocuklarda Hepatit B ve C seroprevalansını araştırmak amaçlandı. Yöntem: Ocak-Eylül 1999 tarihleri arasında Selçuk Üniversitesi Tıp Fakültesi Pediatri polikliniğine ikter dışı nedenlerle getirilen ve yaşları 2 ay-17 yıl arasında değişen 460 çocuk çalışmaya alındı. Bulgular: HBsAg pozitifliği % 0,7 (3/460), antiHBs pozitifliği % 1,3 (6/460), antiHBc pozitifliği %2,4 (11/460) olguda bulundu. HBsAg seropozitifliği 2 ay-6 yaş grubunda en düşük, 13-17 yaş grubunda en yüksek bulundu. Yaşın ilerlemesi ile artan HBV seropozitifliğini azaltmak için Hepatit B aşılama programının yenidoğan döneminde başlatılmasının uygun olacağını düşünmekteyiz. Anti HCV ise bir olguda (% 0.3) pozitif bulunmuştur. Sonuç: Anti HCV prevalansı genel populasyon oranlarına uygundur.Öğe Prader Orchidometer and Ultrasound Can Be Used for Monitoring Testicular Growth: Which Is a More Valid Method?(KARGER, 2011) Atabek, M. E.[Abstract not Available]Öğe Smith-Lemli-Opitz Syndrome: Autopsy with New Morphological Findings(FREUND PUBLISHING HOUSE LTD, 2010) Doğan, K. H.; Atabek, M. E.; Demirci, S.; Ünver Doğan, N.A nine-month-old infant was transported to hospital where he was pronounced dead upon arrival. He was diagnosed with Smith-LemliOpitz Syndrome (SLOS) when he was three months old and he had been treated since then. A week ago, he was discharged from hospital after having had treatment for acute renal failure. His parents were relatives (Fig. 1). Chromosomal analysis revealed a normal male karyotype (46, XY). His 7-dehydrocholesterol level was extremely high (848 µg/ml, Ref: <0.1), androstenedione level was high (0.565 ng/ml, Ref: 0.08-0.5) and anti-Mullerian hormone level was low (4.2 ng/ml, Ref: 35.1-91.1). In renal scintigraphy, effective renal plasma flow was measured 80.6 ml/min for right kidney, but 24.1 ml/min for left kidney. He was taking malnutrition therapy. Infantile-type myelination of the brain was determined in cranial magnetic resonance imaging.Öğe Spinal Epidural Abscess: the Importance of Early Diagnosis and Treatment: Case Report(2001) Levendoğlu, F.; Atabek, M. E.; Uğurlu, H.Spinal epidural abscess (SEA) is a rare disease in the pediatric age group. Early diagnosis is often elusive and treatment is delayed. A 16-year-old boy was admitted our hospital for fever, severe low back pain and progressive neurologic deficit. Magnetic resonance imaging (MRI) revealed a SEA from thoracal 6 to 11. 72 hours after paraplegia occured laminectomy and drainage of the abscess was performed. Appropriate antibiotics was given. But he had no recovery of neurologic function. Permanent paralysis and death usually have been related to delay in diagnosis. The problem with SEA is not treatment but early diagnosis, before severe neurological smptoms occur.
