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Öğe Increased cardiac troponin I concentration in diabetic ketoacidosis(FREUND PUBLISHING HOUSE LTD, 2004) Atabek, ME; Pirgon, O; Oran, L; Erkul, I; Kurtoglu, SObjective: To examine the hypothesis that diabetic ketoacidosis may be associated with some degree of induced injury to heart muscle, related either to acidosis or hyperglycemia. Methods: Nineteen diabetic patients with acute ketoacidosis and 19 healthy children were enrolled in this study. Cardiac troponin I (cTnI), creatine kinase (CK)-MB and myoglobin levels were analyzed soon after admission and after 24 h. Patients were subdivided into two groups according to blood pH. Results: At the time of admission, the diabetic patients had significantly higher values than the controls for cTnI (0.193 +/- 0.008 vs 0.176 +/- 0.006 ng/dl; p < 0.001), CK-MB (24.1 < 2.1 vs 22.7 < 1.2 U/l; p = 0.02), and myoglobin (85.5 < 7.4 vs 52.5 +/- 8.3 mug/dl; p < 0.001). The diabetic patients also had significantly higher values than the controls for CK-MB (24 2.1 vs 22.7 +/- 1.2 U/l; p = 0.02) and for myoglobin (78.5 +/- 2.5 vs 52.5 +/- 8.3 mug/dl; p < 0.001) at 24 h. cTnI had normalized in patients at 24 h. All parameters were significantly different between patients with pH greater than or equal to7.0 and patients with pH <7.0. In addition, serum cTnI levels correlated negatively. with blood pH (r = -0.57, p = 0.026) and HCO3- (r = -0.65, p = 0.008) in the patients with diabetic ketoacidosis on admission. Conclusion: Our findings suggest that diabetic ketoacidosis, particularly when severe, has a detrimental effect on the myocardium.Öğe Oral alendronate therapy for severe vitamin D intoxication of the infant with nephrocalcinosis(FREUND PUBLISHING HOUSE LTD, 2006) Atabek, ME; Pirgon, O; Sert, AVitamin D intoxication is a well-known cause of hypercalcemia in children. We report here the use of oral alendronate for the treatment of hypercalcemia due to vitamin D intoxication in a 7 month-old infant with nephrocalcinosis. The serum calcium levels were normalized without complications. Oral alendronate therapy may be safely used in hypercalcemia due to vitamin. D intoxication in pediatric patients with nephrocalcinosis resistant to hydration, diuretics or corticosteroids.Öğe Oxidative stress in childhood obesity(FREUND PUBLISHING HOUSE LTD, 2004) Atabek, ME; Vatansev, H; Erkul, IObjective: To measure products of free radical damage in childhood obesity. Methods: Plasma free radicals were assayed in 24 children with exogenous obesity and 24 non-obese healthy controls. A new colorimetric method was used that measures the generation of peroxy radicals (D-Roms), first products of the reaction between free radicals and oxygen. Results: D-Roms levels were higher in the obese children than in the non-obese group (33.3 +/- 10.1 mg% of H2O2 vs 22.8 +/- 2.8 mg% of H2O2; p < 0.001). Moreover, D-Roms levels were higher in children with hyperlipidemia than in children with normolipidemia (49.6 +/- 3.1 mg% of H2O2 vs 27.8 +/- 3.2 mg% of H2O2; p < 0.001). D-Roms level was positively correlated with waist-hip ratio, serum total cholesterol, serum triglycerides, serum low-density lipoprotein-cholesterol, systolic blood pressure, diastolic blood pressure and fasting blood glucose in obese children. In a multivariate regression model for obese children, the independent correlates for D-Roms level were systolic blood pressure (p < 0.001) and serum total cholesterol (p < 0.001), with the total variance explained being 82%. Conclusion: Our study demonstrates for the first time that there was increased D-Roms levels in ob se children and adolescents and suggests that increased systolic blood pressure associated with hyperlipidemia may independently contribute to increased oxidative stress in childhood obesity.Öğe Plasma homocysteine levels in children and adolescents with type 1 diabetes(INDIAN ACADEMY PEDIATRICS, 2006) Atabek, ME; Pirgon, O; Karagozoglu, EObjective: Hyperhomocysteinemia has been established as a risk factor for cardiovascular disease. The objective was to investigate total plasma homocysteine concentrations in children. and adolescents with type 1 diabetes and a control group. Method: Twenty-seven children with type 1 diabetes and 27 subjects of an age- and sex-matched control group were recruited. Fasting samples were collected for plasma total homocysteine, serum vitamin B-12, folate, and creatinine. Results: Fasting total homocysteine concentrations showed no difference between patients and controls (5.6 +/- 2.9 mu mol/L vs 5.7 +/- 2.2 mu mol/L; p > 0.05). The diabetic patients had significantly higher serum folate than the healthy controls (11.4 +/- 3.3 ng/mL vs 9.4 +/- 4.1 ng/mL; P = 0.02 and higher serum B-12 than the control group (282.8 +/- 119 pg/mL vs 228.5 +/- 50.9 pg/mL; P = 0.03). Total plasma homocysteine concentration correlated with age (r = 0.44, P = 0.02), weight (r = 0.56, P = 0.002), body mass index (r = 0.57, P = 0.002), folate (r = -0.48, P = 0.01), and creatinine (r = 0.41, P = 0.03) in diabetic patients. In stepwise multivariate regression model for diabetics, the independent correlates for total plasma homocysteine concentration was folate (P = 0.002). Conclusion: We concluded that fasting plasma total homocysteine concentrations were within normal limits in children and adolescents with type 1 diabetes who were without any clinical evidence of microvascular and macrovascular complications.Öğe Prevalence of anti-HAV and anti-HEV antibodies in Konya, Turkey(ELSEVIER SCI IRELAND LTD, 2004) Atabek, ME; Fyndyk, D; Gulyuz, A; Erkul, IObjective: To determine the prevalence of antibodies to hepatitis A (HAV) and E (HEV) Viruses in the different areas of Konya. Methods: Anti-HAV and anti-HEV antibodies were investigated in 210 healthy children randomly selected (100 from rural areas and 110 from urban areas of Konya). None gave a history of previous icterus nor other signs of hepatitis, had received blood transfusion and HAV vaccine, or had been on hemodialysis. Results: Evidence of HAV infection Occurred in children under the age of 6 years. The seroprevalence rate was 67.8% in rural areas and 25.8% in urban areas. This increased rapidly with age and became universal after 11 years of age in both areas. In contrast, HEV infections were not detected until children were 6-11 year olds, and the 5.2% seroprevalence rate ill urban areas and 8.5% seroprevalence rate in rural areas in this age group did not significantly increase in older age group. The prevalence of anti-HAV as well as anti-HEV was significantly higher in children with poor socio-economic conditions in both areas. Conclusions: These results Suggest that HAV infection in rural areas of Konya is widespread and that environmental and socio-economic factors play a major role in its transmission. In contrast, hepatitis E is not a public health problem in Konya. (C) 2003 Elsevier Ireland Ltd. All rights reserved.Öğe Relation of serum leptin and insulin-like growth factor-1 levels to intima-media thickness and functions of common carotid artery in children and adolescents with type 1 diabetes(WILEY, 2004) Atabek, ME; Kurtoglu, S; Demir, F; Baykara, MBackground and aim: Leptin and insulin-like growth factor-1 (IGF-1) have been suggested to be involved in the pathogenesis of atherosclerosis. The aim of this study was to evaluate the relationship between serum leptin, IGF-1 and intima-media thickness (IMT) and functions of common carotid artery (CCA) in children and adolescent patients with type 1 diabetes. Material and methods: Serum leptin and IGF-1 levels were measured in 45 diabetic patients (23 girls and 22 boys). Age, diabetes duration as well as major cardiovascular risk factors, including anthropometric and metabolic parameters, were matched between girls and boys. The relation of serum leptin and IGF-1 levels to CCA structure and functions were measured by ultrasonography as IMT, cross-sectional compliance (CSC), cross-sectional distensibility (CSD), diastolic wall stress (DWS) and incremental elastic modulus (IEM). Results: Serum leptin levels of diabetic girls were higher than those in the boys (21.8 +/- 14.5 mug/l vs 8.9 +/- 10.6 mug/l, p = 0.002). However, the difference for serum IGF-1 levels was not significant between diabetic girls and boys (240.7 +/- 96.8 ng/ml vs 234.7 +/- 93.2 ng/ml; p > 0.05). In all subjects, leptin levels were correlated with CSC (p = 0.04), CSD (p = 0.04) and IEM (p = 0.01), and IGF-I levels were only correlated with CSC (p = 0.01). Leptin did not show any correlation with ultrasonographic measurements in both girls and boys separately. IGF-1 was correlated with CSC (p = 0.001), CSD (p = 0.002) and IEM (p < 0.001) in boys but not in girls. In a multivariate regression model, IGF-1 emerged as independent correlates for mean CSD and IEM in boys but not in girls. Conclusion: Serum leptin and IGF-1 levels in children and adolescent patients with type 1 diabetes are associated with functions of common carotid artery, and the association of IGF-1 levels is influenced by sex.Öğe The role of cord blood IGF-I levels in preterm osteopenia(FREUND PUBLISHING HOUSE LTD, 2006) Atabek, ME; Pirgon, O; Yorulmaz, A; Kurtoglu, SObjective: Osteopenia is a frequent condition in preterm infants. This prospective study was designed to assess the relationship between cord blood insulin-like growth factor-I (IGF-I) levels and bone mineralization in healthy premature infants. Methods: Twenty preterm infants (ten males and ten females) were studied. We determined the bone mineral density (BMD) and bone mineral content (BMC) of healthy premature infants by dual-energy X-ray absorptiometry and also studied the correlation between IGF-I and other parameters and the influence of cord blood IGF-I concentrations on bone mineralization in these infants. Results: The mean concentration of IGF-I was 13.6 +/- 16.9 ng/ml and BMD and BMC were 0.249 +/- 0.06 g/cm(2) and 3.09 +/- 1.18 g, respectively. Cord serum levels of IGF-I had significantly positive correlations with BMD (r = 0.605, p = 0.008), but not BMC (r = 0.242, p = 0.367). In stepwise regression analysis, IGF-I emerged as a significant predictor of BMD (beta = 0.595, p 0.015) contributing to 35.4% of its variability. Conclusion: We found a relationship between cord blood IGF-I and BMD in preterm neonates, suggesting that even within an unremarkable population, IGF-I might be important to ensuring bone health.Öğe Serologic response to hepatitis B vaccination in children with isolated anti-HBc(OXFORD UNIV PRESS, 2006) Atabek, ME; Erkul, I[Abstract not Available]Öğe Serum magnesium concentrations in type 1 diabetic patients: Relation to early atherosclerosis(ELSEVIER IRELAND LTD, 2006) Atabek, ME; Kurtoglu, S; Pirgon, O; Baykara, MHypomagnesemia and sub-clinical atherosclerosis are common in type 1 diabetic patients, and are especially common in poorly controlled and chronically treated diabetics. The aim of this study was to evaluate the relationships between serum magnesium (Mg) and intima-media thickness (IMT), and functions, of common carotid artery (CCA), accepted as markers of early carotid atherosclerosis in type I diabetic patients. Serum magnesium levels were measured in 51 diabetic patients (26 girls and 25 boys). Age, duration of diabetes as well as major cardiovascular risk factors, including anthropometric and metabolic parameters were matched between girls and boys. CCA structure and functions were measured by ultrasonography as IMT, cross-sectional compliance (CSC), cross-sectional distensibility (CSD), diastolic wall stress (DWS), and incremental elastic modulus (IEM). The difference for serum Mg was significant between diabetic girls and boys (0.75 +/- 0.09 mmol/l versus 0.86 +/- 0.14 mmol/l; p = 0.02). Mg levels were correlated with IMT (r = -0.58, p = 0.004) and DWS (r = -0.49, p = 0.01) in girls and with IMT (r = -0.55, p = 0.007) and DWS (r = -0.46, p = 0.03) in boys. In a multivariate regression model, Mg, systolic blood pressure and waist-hip ratio emerged as independent correlates for mean IMT in girls with the total variance explained being 63%, and Mg and triglycerides emerged as independent correlates for mean IMT in boys with the total variance explained being 68%. Mg did not emerge as independent correlates for mean DWS in both girls and boys. Serum magnesium levels in children and adolescent patients with type I diabetes are associated with early atherosclerosis. (c) 2005 Elsevier Ireland Ltd. All rights reserved.Öğe Tetanus in a fully immunized child(ELSEVIER SCIENCE INC, 2005) Atabek, ME; Pirgon, O[Abstract not Available]Öğe Zimmermann-Laband syndrome in an infant with an atypical histologic finding(SPRINGER, 2005) Atabek, ME; Pirgon, O; Sert, A; Toy, HZimmermann-Laband syndrome is an inherited disorder that is characterized by abnormalities of the head, face, hands, and feet. Most children with this disorder have generalized hypertrichosis, large gingivae, and hypoplasia of the fingernails and toenails. We report a male infant who exhibited typical features of Zimmermann-Laband syndrome with an unusual histopathologic finding. Excised tissue from the infant's gingivae showed papillary projections that were composed of hyperplastic stratified squamous epithelium with different amounts of keratinization.
