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    Effect of pentoxifylline on biochemical parameters in endotoxaemic New Zealand white rabbits
    (NATL VETERINARY RESEARCH INST, 2004) Yazar, E; Col, R; Uney, K; Atalay, B; Elmas, M; Tras, B
    Effect of pentoxifylline on biochemical values in endotoxaemic rabbits was investigated. Forty rabbits were divided into four equal groups. Group 1, served as a control group, group 2: lipopolysaccharide was injected intravenously, group 3: pentoxifylline was injected intraperitoneally, group 4: lipopolysaccharide and pentoxifylline were injected simultaneously. Serum samples were collected 6 h after the treatments. Serum alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase, total bilirubin, creatinine, urea, glucose, total protein, albumin, triglyceride, cholesterol, sodium, potassium, chloride, phosphorus and magnesium levels were measured. Pentoxifylline induced protective effect on the liver and kidney in endotoxaemia, but did not show any protective effect on lipid metabolism.
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    Effect of pentoxifylline on endotoxin-induced haemostatic, disturbances in rabbits
    (AKADEMIAI KIADO, 2005) Col, R; Keskin, E; Atalay, B
    Pentoxifylline (PTX, a methylxanthine derivative) has been found to interrupt early gene activation for tumour necrosis factor, interleukin-1, interleukin-6 and tissue factor production and to improve survival from experimental sepsis. During endotoxaemia, lipopolysaccharide (LPS, endotoxin) and proinflammatory cytokines trigger the development of disseminated intravascular coagulation (DIC) via the tissue factor-dependent pathway of coagulation. The present study was undertaken to determine whether pentoxifylline could prevent coagulation disturbances in LPS-treated rabbits. Endotoxaemia was induced with E. coli lipopolysaccharide in New Zealand White rabbits. Forty rabbits were used and divided into four equal groups. Group I served as a control group; Group 2: lipopolysaccharide was injected intravenously, Group 3: pentoxifylline was injected intraperitoneally, Group 4: lipopolysaccharide and pentoxifylline were injected simultaneously. Blood samples were collected 6 h after the treatments. In rabbits with endotoxin-induced DIC, platelet count, leukocyte count, percentage of differential leukocyte values, fibrinogen level, antithrombin III (AT-III) and protein C (PC) activity were decreased. Moreover, activated partial thromboplastin time (APTT) and prothrombin time (PT) were prolonged when compared to the control group. In conclusion, haemostatic disturbances associated with endotoxin-induced DIC were moderately suppressed by the administration of PTX.
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    Selected haematological and biochemical values in ostrich chicks and growers
    (EUGEN ULMER GMBH CO, 2005) Durgun, Z; Keskin, E; Col, R; Atalay, B
    In this study, some haematological and biochemical parameters were determined in healthy ostriches (Struthio camelus) of different ages. For this purpose 15 chicks and 13 growers obtained from a commercial hatchery in Konya environment were used. In blood samples, red blood cell counts, haemoglobin amount, haematocrit value, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, red blood cell size (mean corpuscular diameter), thrombocyte counts, white blood cell counts and percentage of leukocyte types were determined. Additionally, cholesterol, triacylglycerol, creatinine, creatinine kinase, glucose, aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, total protein and albumin levels were measured in plasma samples. Although the red blood cell counts, haematocrit values, glucose levels and lymphocyte percentage of the chicks were lower than for growers, the heterophil percentage, total protein, cholesterol, triacylglycerol and creatinine kinase were higher than in growers. There was no significant difference in the other parameters investigated between chicks and growers. Based on the results, it was concluded that selected haematological and biochemical values were influenced by the age differences of the ostriches and the data obtained in the study could be useful to establish some baseline values for haematological and biochemical parameters in different ages of the ostriches.