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    Effect of paclitaxel and resveratrol on New Zealand rabbit semen
    (Wolters Kluwer Medknow Publications, 2018) Ozturk C.; Ataman M.B.
    Objective: To examine the effects of paclitaxel and resveratrol on rabbit semen. Methods: This study consisted of four groups: control group (40 mL saline), paclitaxel group (5 mg/kg paclitaxel), resveratrol group (4 mg/kg resveratrol) and paclitaxel+resveratrol group (5 mg/kg paclitaxel+4 mg/kg resveratrol). Administrations were i.v. (in 40 mL saline) and continued 8 weeks. Sperm motility was evaluated using phase-contrast microscopy. Mitochondrial activity, membrane and acrosome integrity were performed by fluorescence staining. Lipid peroxidation, total glutathione and antioxidant potential levels were determined by spectrophotometry. Results: Paclitaxel decreased the sperm motility and fluorescence staining results compared to the control (P<0.05). The paclitaxel and resveratrol group showed better results of the same parameters compared to the paclitaxel group (P<0.05). No significant difference was observed in lipid peroxidation, total glutathione, antioxidant potential and fertility results (P>0.05). Results of this study showed that paclitaxel decreased semen parameters and resveratrol had a protective effect on these parameters. Conclusions: Paclitaxel has negative effects on spermatological indicators and biochemical assays, while resveratrol prevents these negative effects of paclitaxel. © Copyright 2018, Hainan Medical University.
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    Effect of sildenafil (Viagra®) on penile erection and semen volume and characteristics in kangal dogs
    (2009) Çoyan K.; Ataman M.B.; Özalp B.; Tepeli T. C.
    In this study, the effects of sildenafil administration on penile erection and semen volume and characteristics in Kangal dogs were studied. A total of 5 Kangal dogs, aging 3-6 years, and with a known fertility were used. In each application, sildenafil was administered orally at a dosage of 50 mg, 60 minutes prior to semen collection. Semen was collected 12 times at 3-day intervals by digital manipulation. After collected, semen was examined for volume (first, second, and third fractions), ejaculation time, and spermatological characteristics. Dogs were rested for 3 weeks after the last semen collection. Following the rest period, semen collection was experienced 12 times at 3-day intervals by digital manipulation without sildenafil application. Sildenafil administration enhanced the volume of the second and third fractions, compared to the non-sildenafil group (1.1 ml versus 0.7 ml and 11 ml versus 6 ml, respectively, P<0.05), and increased the total ejaculation time (11.8 minutes versus 7 minutes, P<0.05). On the other hand, there were no significant differences between the sildenafil and non-sildenafil groups for spermatological characteristics (P>0.05). As a conclusion, sildenafil could be used in dogs, having problems in response to digital manipulation, for penile erection and successful semen collection.
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    Synchronization of estrus in cows using double PGF2?, GnRH-PGF2? and hCG-PGF2? combination
    (2003) Çoyan K.; Ataman M.B.; Erdem H.; Kaya A.; Kasikci G.
    The aim of this study was to compare the effectiveness of treatments combining GnRH and PGF2? hCG and PGF2? combinations, and double PGF2? administration for synchronization of estrus in cows. This study was carried out in 30 Brown Swiss cows, aging 3 - 5 years. The cows were randomly divided into three groups. In group I (n = 10), the cows were treated with an intramuscular injection of 20 ?g GnRH (day = 0) at a random stage of the estrous cycle followed by intramuscular injection of 0.150 mg PGF2? 7 days later (day = 7). In group II (n = 10), the cows were treated with an intravenous injection of 3000 IU hCG (day = 0) at a random stage of the estrous cycle followed by intramuscular injection of 0.150 mg PGF2? 7 days later (day = 7). In group III (n = 10), the cows were received two injections of 0.150 mg PGF2? 11 day apart (day = 0, and 11). GnRH (10 ?g) was injected intramuscularly to the cows 48 hours after the injection of PGF2? in the groups I and II, and after the second PGF2? in group III. The cows were inseminated 12 hours after the GnRH injections. Blood samples were collected daily to determine plasma progesterone levels for 13 days in the groups I and II, and for 15 days in the group III starting from the day of GnRH, hCG and first PGF2? injections respectively. The mean interval injections-estrus, injections-ovulation, synchronization and pregnancy rates of the groups were determined. Plasma progesterone levels on day 0 and at estrous were similar among the three groups, but it was significantly higher (p < 0.01) in the groups I and II than in the group III on the day of PGF2? administration. The mean GnRH injections-estrus and injections-ovulation interval in the groups I, II and III were 52.2 ± 1.69, 48.4 ± 1.34 and 68.2 ± 1.31 hours; 70.4 ± 1.17, 67.3 ± 1.36 and 90.6 ± 2.15 hours, respectively and were significantly different (p < 0.01). The synchronization rates tend to be higher in the groups I and II (100%) than in the group III (80%), and pregnancy rates of the groups I, II and III were 60%, 60% and 30%, respectively. As a conclusion, application of a GnRH and hCG analogue prior to synchronization of estrus with an injection of PGF2? may provide better results than two injections of PGF2? for estms synchronization in cows.