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    Effect of Tilmicosin on Serum Cytokine Levels in the Endotoxemia
    (MEDWELL ONLINE, 2009) Uney, Kamil; Er, Ayse; Avci, Gulcan Erbil; Bulbul, Aziz; Elmas, Muammer; Yazar, Enver
    The effect of tilmicosin on serum cytokine concentrations were investigated in healthy and lipopolysaccharide-treated mice. The mice were divided into 3 groups. Lipopolysaccharide (250 mu g, Escherichia coli 0111:B4, intraperitoneally) was injected into the positive control group. The other 2 groups received tilmicosin (20 mg kg(-1), subcutaneously) concurrently without or with lipopolysaccharide. After treatment, serum samples were collected at 0, 1.5, 3, 6, 12 and 24 h. Serum tumor necrosis factor, interleukin-1 and interleukin-10 levels were determined by enzyme-linked immunosorbent assay. Lipopolysaccharide increased all cytokine levels in the healthy mice. Tilmicosin slightly induced interleukin-1 production in the healthy mice, while it had no effect on tumor necrosis factor or interleukin-10 productions. However, tilmicosin elevated (p<0.05) tumor necrosis factor, interleukin-1 and interleukin-10 levels in lipopolysaccharide-treated mice. In conclusion, these data suggest that tilmicosin stimulates both proinflammatory and antiinflammatory cytokines at the dose recommended for infection.
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    SERUM OXIDATIVE STATUS AND ADENOSINE DEAMINASE ACTIVITY IN DOGS WITH TRANSMISSIBLE VENEREAL TUMOUR
    (NATL VETERINARY RESEARCH INST, 2009) Aydin, Ibrahim; Bulbul, Aziz; Avci, Gulcan Erbil; Celik, Haci Ahmet
    Ten adult healthy hitches and 10 bitches with transmissible venereal tumour were investigated. Scrum malondialdehyde, nitric oxide, antioxidant activity, vitamin C, retinol, beta-carotene, adenosine deaminase activity, oestradiol-17 beta. progesterone, and cortisol were determined. Oxidative damage and increased adenosine deaminase activity were (P<0.05) demonstrated in bitches with the tumour compared to healthy bitches. In conclusion, antioxidant supplementation may be useful in the treatment of bitches with transmissible venereal tumour.