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    Erythromycin Inhibits Prostaglandin F2?-İnduced Contractions of Myometrium Isolated From Non-Pregnant Rats
    (2002) Çelik, Hüsnü; Ayar, Ayar; Baltacı, Abdülkerim; Tuğ, Niyazi
    Objective: The aim of this study was to investigate the effects of erythromycin on prostaglandin F2? (PGF2?)-induced contractions of isolated myometrial strips from non-pregnant rats. Design: In vitro pharmacological study. Setting: Firat University Faculty of Medicine. Sample: Myometrium samples were taken from 55 adult Wistar rats. Methods: Myometrial strips were isolated from mature, non-pregnant Wistar rats. Isometric contractions of these strips were induced with 1 ?M PGF2?. Effects of 0.01, 0.1, 0.2, 0.5 and 1 mM erythromycin on the frequency and amplitude of these PGF2?-induced contractions were recorded. Main outcome measures: The inhibition of prostaglandin F2?-induced contractions in vitro. Results: Application of 0.01 mM erythromycin had no effect on either amplitude or frequency of contractions. However, 0.1, 0.2, 0.5 and 1 mM erythromycin decreased the frequency and amplitude of PGF2?-induced contractions. The inhibitory effect of erythromycin on amplitude was 27%, 38%, 54% and 83% (P < 0.05), and that on frequency was 10%, 16%, 32% and 61% (P < 0.05) at 0.1, 0.2, 0.5 and 1 mM concentrations, respectively. Conclusion: The results of this study demonstrate that erythromycin inhibits PGF2?-induced contractions in rat myometrium. Because PGF2?-induced contractions have been suggested to be involved in the pathogenesis of primary dysmenorrhoea, effects of erythromycin in this clinical entity may present a new approach for the treatment.