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Öğe Assessment of the effects of antihistamine drugs on mood, sleep quality, sleepiness, and dream anxiety(TAYLOR & FRANCIS LTD, 2014) Ozdemir, Pinar Guzel; Karadag, Ayse Serap; Selvi, Yavuz; Boysan, Murat; Bilgili, Serap Gunes; Aydin, Adem; Onder, SevdaObjective. There are limited comparative studies on classic and new-generation antihistamines that affect sleep quality and mood. The purpose of this study was to determine and compare the effects of classic and new-generation antihistamines on sleep quality, daytime sleepiness, dream anxiety, and mood. Methods. Ninety-two patients with chronic pruritus completed study in the dermatology outpatient clinic. Treatments with regular recommended therapeutic doses were administered. The effects of antihistaminic drugs on mood, daytime sleepiness, dream anxiety, and sleep quality were assessed on the first day and 1 month aft er. Results. Outpatients who received cetirizine and hydroxyzine treatments reported higher scores on the depression, anxiety, and fatigue sub-scales than those who received desloratadine, levocetirizine, and rupatadine. Pheniramine and rupatadine were found to be associated with daytime sleepiness and better sleep quality. UKU side effects scale scores were significantly elevated among outpatients receiving pheniramine. Classic antihistamines increased daytime sleepiness and decreased the sleep quality scores. New-generation antihistamines reduced sleep latency and dream anxiety, and increased daytime sleepiness and sleep quality. Conclusion. Both antihistamines, significantly increased daytime sleepiness and nocturnal sleep quality. Daytime sleepiness was significantly predicted by rupadatine and pheniramine treatment. Cetirizine and hydroxyzine, seem to have negative influences on mood states. Given the extensive use of antihistamines in clinical settings, these results should be more elaborately examined in further studies.Öğe The Comparison of Socio-Demographic and Clinical Variables of Inmates Using Gabapentin For Medicinal Purposes and Those Abusing The Drug(JOURNAL NEUROLOGICAL SCIENCES, 2017) Cicekci, Faruk; Yuksekkavas, Dincer; Aydin, Adem; Karaibrahimoglu, Adnan; Uca, Ali UlviObjective: To compare the socio-demographic and clinical data of inmates using gabapentin for medicinal purposes and those abusing the drug. Methods: The study included inmates of the Konya E-Type Prison who used gabapentin between June 2012 and December 2014 and were admitted to the prison polyclinic. The participants were divided into two groups; those using gabapentin due to existing symptoms without any labeled indication (Group 1), and those using the medication due to disorders with labeled indications (Group 2). Both groups were investigated in terms of drug addiction, drug abuse, and gabapentin abuse according to the Diagnostic and Statistical Manual-Text Revision (DSM IV-TR). Results: Nearly all inmates (n=21) using gabapentin with off-label indications (Group 1) reported using it due to muscle pain, neuropathic pain, sleep disorder, signs of anxiety, sweating, trembling, and nausea-vomiting, whereas those using gabapentin with labeled indications (Group 2) reported using it because of their diseases, such as diabetic neuropathy and epilepsy. Alcohol/substance abuse was found higher among the first-degree relatives of those using gabapentin with off-label indications (P < 0.001). The rates of substance dependence (n=10) and substance abuse (n=13) were significantly higher in Group 1 than in Group 2 (P < 0.001). Conclusion: The inmates who were diagnosed as having drug addiction and substance abuse according to the DSM-IV-TR used gabapentin after entering prison to prevent opioid withdrawal symptoms.Öğe Comparison of Venlafaxine Alone Versus Venlafaxine Plus Bright Light Therapy Combination for Severe Major Depressive Disorder(PHYSICIANS POSTGRADUATE PRESS, 2015) Ozdemir, Pinar Guzel; Boysan, Murat; Smolensky, Michael H.; Selvi, Yavuz; Aydin, Adem; Yilmaz, EkremObjective: Phototherapy, ie, bright light therapy, is an effective and safe treatment of major depressive disorder (MDD). It exerts rapid mood-elevating activity, similar to antidepressant medications, most likely mediated through both monoaminergic and circadian system melatonergic mechanisms. We assessed the efficiency of bright light therapy as an adjuvant treatment to antidepressant pharmacotherapy in patients with severe MDD randomized by Hamilton Depression Rating Scale (HDRS) score to either (1) 150 mg venlafaxine hydrochloride daily at 7: 00 am or (2) 150 mg venlafaxine plus 60-minute light of 7000 lux the initial week of clinical management (venlafaxine + bright light therapy) daily at 7: 00 am. Method: 50 inpatients with severe MDD at the Psychiatry Clinic of Yuzuncu Yil University Training and Education Hospital participated. The study, which was conducted from January 2013 through June 2014, entailed patients diagnosed with severe MDD based on DSM-IV-TR for the first time. Mood states were assessed by the HDRS, Profile of Mood States (POMS), and Beck Depression Inventory (BDI) before treatment and at 1, 2, 4, and 8 weeks of treatment. Results: On the basis of the HDRS score as the primary outcome variable, both strategies significantly improved depression and negative mood states already at the first treatment week (P < .001). Differences in therapeutic effects by treatment strategy were remarkable at the second and fourth weeks of clinical management (P = .018 and P = .011, respectively), with beneficial effects continuing until trial Conclusion. Those treated with venlafaxine + bright light therapy evidenced significantly lower HDRS depression scores (P < .05) as well as BDI scores (P < .05) and POMS negative mood states scores (depression-dejection, tension-anxiety, anger-hostility, fatigue-inertia, and confusion-bewilderment subscales; all P < .05) after the second week. At week 4 of the trial, 19 (76%) of the 25 venlafaxine + bright light therapy patients versus just 11 (44%) of the 25 venlafaxine patients (P < .05) attained the target goal of treatment, a HDRS score = 13, indicative of mild depression, and, although not statistically significant in our small sample study (P = .36), at week 8, 76% of venlafaxine + bright light therapy patients (n = 19) versus just 64% of the venlafaxine patients (n = 16) experienced complete remission of depression (HDRS score = 7). Conclusions: Both venlafaxine and venlafaxine + bright light therapy treatment strategies significantly reversed the depressive mood of patients with severe MDD; however, the latter induced significantly stronger and more rapid beneficial effects. Future longer-term studies with large sample sizes, nonetheless, are required to confirm and generalize these results to patients of diverse ethnicities and cultures with both severe and mild MDD. (C) Copyright 2015 Physicians Postgraduate Press, Inc.Öğe Dissociative Symptoms Secondary to Piracetam: A Case Report(KURE ILETISIM GRUBU A S, 2013) Aydin, Adem; Ozdemir, Pinar Guzel; Selvi, Yavuz; Uguz, Faruk; Cetinkaya, NuralayPiracetam is a cyclic derivative of gamma-aminobutyric acid that is often used in neurology. Piracetam is an antithrombotic, neuroprotective agent which improves cognitive performance. Piracetam is indicated for vertigo in clinical practice. The etiology of dissociation is not precisely defined. In pharmacotherapy studies, depersonalization is the basic dissociative symptom. In this article, we have reported a case with the diagnosis of peripheral vertigo where piracetam was used as part of combination therapy. However dissociative symptoms like depersonalization and derealization occurred after piracetam use and these symptoms disappeared after discontinuation of piracetam.Öğe The Effect of Alexithymia on Somatization and Sleep Quality in Patients with Depression(AVES, 2013) Aydin, Adem; Selvi, Yavuz; Guzel Ozdemir, PinarBackground: The aim of the study was to determine the effect of alexithymia on sleep quality and tendency to somatization in patients with depression. Methods: Eighty-five patients with depression, who applied to the outpatient unit of psychiatry, were included in the study. The Beck Depression Inventory (BDI), Toronto Alexithymia Scale (TAS), Symptom Interpretation Questionnaire (SIQ), and the Pittsburgh Sleep Quality Index (PSQI) were administered to the patients. Results: Depressive patients were divided into two groups: alexithymic patients and non-alexithymic patients. There were significant differences in scores of BDI, psychologizing and somatizing subscale of the SIQ and daytime dysfunction subscale of the PSQI in alexithymic patients. Conclusion: It was found that depressive patients have higher levels of alexithymic features and somatization tendencies in this study. Moreover, alexithymic patients have more frequent psychological and somatic attributions and increased loss of daytime functionality. (Archives of Neuropsychiatry 2013; 50: 65-69)Öğe The Effects of Sleep Deprivation on Dissociation and Profiles of Mood, and Its Association with Biochemical Changes(GALENOS YAYINCILIK, 2015) Selvi, Yavuz; Kilic, Sultan; Aydin, Adem; Ozdemir, Pinar GuzelIntroduction: Sleep deprivation is a method, which has being used in order to comprehend the functions of sleep both in healthy individuals and for the patients of depression with in treatment, for a long time. The objective of our present study is to examine the relation between hormonal values, which are known for being related to the effects of these said changes determined in the mood, dissociation and thought suppression in healthy individuals after one night of sleep deprivation implementation. Methods: One night sleep deprivation was performed on a total of thirty-two healthy volunteers (16 males and 16 females) who were included in the study. Blood samples were taken from the individuals before and after sleep deprivation implementation in order to determine cortisol, dehydroepiandrosterone-sulfate (DHEA-S) and Thyroid Functions' Levels tests. In order to evaluate the effects of the sleep deprivation on moods, "White Bear Suppression Inventory (WBSI)" has been conducted, with an aim of evaluating thought suppression, "Profile of Mood States (POMS)", "Dissociative Experiences Scale (DES)" with a purpose of realizing any dissociation tendency. Results: On the individuals who have been implemented for sleep deprivation, a decrease on depression and vigor-activity sub-scales values was detected, and an increase was determined on fatigue sub-scales values of "POMS". While the values of DES were found to have been statistically increased after sleep deprivation, also a significant decrease was determined on WBSI values. Even if there hasn't been any significant statistical change determined on cortisol levels after sleep deprivation, yet there had been some significant changes detected on Thyroid Stimulating Hormone (TSH), fT3, fT4, and DHEA-S levels. Decrease in "POMS" depression sub-scale values and increase on fatigue sub-scale values were determined on the individuals whose sT4 levels were found to be increased significantly in statistic manner after the sleep deprivation. Conclusion: According to the results of our study, sleep deprivation for one night was determined to cause decrease on depressive mood, increase on dissociative symptoms and to lower the tendency of suppressing the unwanted thoughts, consciously. The fact of being obtained lower depression values, on the individuals with the increased DHEA-S levels after the sleep deprivation meets with the information claiming that the high DHEA-S levels may be deemed as protectors against the negative effects of the stress.Öğe Is time of childbirth affected by chronotype of the mother?(TAYLOR & FRANCIS LTD, 2013) Guler, Ayse; Aydin, Adem; Selvi, Yavuz; Dalbudak, TunaWe have investigated if biological rhythms, which affect many physiological and pathological events, influence the time of birth. Two hundred and sixty-three cases who were hospitalized with a diagnosis of active labor and who delivered vaginally were enrolled in the study. Information about the age, gravidity, parity, gestational age on admission, and time of onset of labor and birth was registered. A Morningness-Eveningness Questionnaire (MEQ) was administered for determining the patients' chronotypes and dividing them into a morning- or evening-type group. While 20 (35%) of the morning-types delivered between 18:00 and 24:00h, only 11 (19%) of them delivered between 06:00 and 12:00h. From the evening types, 6 (33%) delivered between 18:00 and 24:00h and 3 (17%) between 06:00 and 12:00h. We conclude that there was no statistically significant difference between the chronotypes in terms of delivery time.Öğe Mood and metabolic consequences of sleep deprivation as a potential endophenotype' in bipolar disorder(ELSEVIER, 2013) Aydin, Adem; Selvi, Yavuz; Besiroglu, Lutfullah; Boysan, Murat; Atli, Abdullah; Ozdemir, Osman; Kilic, SultanIt has been commonly recognized that circadian rhythm and sleep/wake cycle are causally involved in bipolar disorder. There has been a paucity of systematic research considering the relations between sleep and mood states in bipolar disorder. The current study examines the possible influences of sleep deprivation on mood states and endocrine functions among first-degree relatives of patients with bipolar disorder and healthy controls. Blood samples were taken at two time points in the consecutive mornings at predeprivation and postdeprivation periods. Participants simultaneously completed the Profiles of Mood States at two time points after giving blood samples. Plasma T3 and TSH levels increased after total sleep deprivation in both groups. Sleep deprivation induced TSH levels were reversely associated with depression-dejection among healthy controls. A paradoxical effect was defected for only the first-degree relatives of the patients that changes in plasma cortisol levels negatively linked to depression-dejection and anger-hostility scores after total sleep deprivation. Plasma DHEA levels became correlated with vigor-activity scores after sleep deprivation among first-degree relatives of bipolar patients. On the contrary, significant associations of depression-dejection, anger-hostility, and confusion-bewilderment with the baseline plasma DHEA levels became statistically trivial in the postdeprivation period. Findings suggested that first-degree relatives of patients with bipolar disorder had completely distinct characteristics with respect to sleep deprivation induced responses in terms of associations between endocrine Functions and mood states as compared to individuals whose relatives had no psychiatric problems. Considering the relationships between endocrine functions and mood states among relatives of the patients, it appears like sleep deprivation changes the receptor sensitivity which probably plays a pivotal role on mood outcomes among the first-degree relatives of patients with bipolar disorder. (C) 2013 Elsevier B.V. All rights reserved.Öğe The role of patient chronotypes on circadian pattern of chronic pruritus: a latent growth modeling analysis(TAYLOR & FRANCIS LTD, 2013) Bilgili, Serap Gunes; Aydin, Adem; Selvi, Yavuz; Karadag, Ayse Serap; Boysan, Murat; Onder, Sevda; Yilmaz, Hatice BurakgaziChronic pruritus is a serious medical and psychiatric disorder that can have a huge impact on a patient's quality of life. Hence, we aimed to examine whether the chronotype characteristics impact on the severity of pruritus throughout the day. In our study we included 83 idiopathic chronic pruritus patients who did not have any underlying dermatological, systemic, or metabolic diseases. We examined the change in the severity of itching symptoms throughout 24 h at four time points. The latent growth modeling approach was used to assess the significance of the chronotype effect on symptom severity after controlling for age, gender, and depression. The patients with morning chronotype characteristics reported more severe itching symptoms later in the day, while the patients with evening chronotype characteristics complained of more severe itching earlier in the day. These findings suggest that chronobiological factors might play a deterministic role on the symptom severity.
