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    Hyperthyroidism causes lipid peroxidation in kidney and testis tissues of rats: Protective role of melatonin
    (MAGHIRA & MAAS PUBLICATIONS, 2005) Mogulkoc, R; Baltaci, AK; Oztekin, E; Aydin, L; Tuncer, I
    OBJECTIVE: The present study aimed at determining how 3-weeks intraperitoneal melatonin administration affected oxidative stress caused by experimental hyperthyroidism. MATERIALS AND METHODS: The study was conducted on 30 male rats of Spraque-Dawley species. The experimental animals were divided to 3 groups (control, hyperthyroidism and hyperthyroidism+melatonin). The supplementation was continued for 3 weeks after which the animals were sacrified and tissue malondyaldehyde (MDA) and glutathione (GSH) levels were determined. RESULTS: MDA levels in kidney and testis tissues in hyperthyroidism group were higher than those in control and hyperthyroidism+melatonin administered groups (p < 0.001) and levels in hyperthyroidism + melatonin administered group were higher than those in the control group (p < 0.001). The highest GSH levels were obtained in hyperthyroidism + melatonin-administered group (p < 0.001) and GSH levels in hyperthyroidism group were higher than those in the control group (p < 0.001). CONCLUSION: Results of the study demonstrate that hyperthyroidism induced by 3-weeks L-thyroxine administration increased oxidative stress in kidney and testis tissues and that although melatonin administration inhibited this stress to a certain extent, it could not bring the stress down to the level in controls.
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    Melatonin prevents oxidant damage in various tissues of rats with hyperthyroidism
    (PERGAMON-ELSEVIER SCIENCE LTD, 2006) Mogulkoc, R; Baltaci, AK; Oztekin, E; Aydin, L; Sivrikaya, A
    Impairment of thyroid functions brings about pathological changes in different organs of body. Findings of in vivo and in vitro studies indicate that thyroid hormones have a considerable impact on oxidative stress. Melatonin reduces oxidative damage through its free radical eliminating and direct anti-oxidant effects. The present study was undertaken to determine how a 3-week period of intraperitoneal melatonin administration affected oxidative damage caused in experimental hyperthyroidism in rat. The experimental animals were divided into 3 groups (control, hyperthyroidism, hyperthyroidism+melatonin). Malondialdehyde (MDA) and glutathione (GSH) levels were determined in different tissues. MDA levels in cerebral, liver and cardiac tissues in hyperthyroidism group were significantly higher than those in control and hyperthyroidism+melatonin supplemented groups (p < 0.001). The highest GSH levels were observed in the group that was administered melatonin in addition to having hyperthyroidism (p < 0.001). These results show that hyperthyroidism increased oxidative damage in cerebral, hepatic and cardiac tissues of rat. Melatonin supplementation may also suppress oxidative damage. (c) 2006 Elsevier Inc. All rights reserved.
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    Pinealectomy inhibits antioxidant system in rats with hyperthyroidism
    (MAGHIRA & MAAS PUBLICATIONS, 2005) Mogulkoc, R; Baltaci, AK; Aydin, L; Oztekin, E; Sivrikaya, A
    OBJECTIVE: Thyroid hormones regulate energy metabolism and act on the mitochondria, which is an important source of free radicals in the cell. Reactive oxygen types play a significant role in physiological mechanisms, but in excessive amounts they can cause oxidative damage in molecules. The aim of the present study was to determine levels of lipid peroxidation caused by induced hyperthyroidism in cerebral, hepatic and cardiac tissues of pinealectomized rats. METHODS: Experimental animals used in the study were allocated to three groups as general control group, hyperthyroidism-sham pinealectomy group and hyperthyroidism-pinealectomy group. GSH and MDA levels in cerebral, hepatic and cardiac tissues were evaluated at the end of the 3-week study period. RESULTS: It was found that MDA levels in cerebral, hepatic and cardiac tissues were the highest in hyperthyroidism and pinealectomy group and that these values were higher in hyperthyroidism-sham pinealectomy group than in the control group (p < 0.001). it was seen that tissue GSH levels significantly increased in hyperthyroidism-sham pinealectomy group (p < 0.001) and that the increase in hyperthyroidism and pinealectomy group was higher than the increase in the control group only (p < 0.001). CONCLUSION: Results of our study show that MDA and GSH levels in cerebral, hepatic and cardiac tissues increased due to hyperthyroidism and that the increase in MDA levels became more evident and GSH levels were significantly suppressed after pinealectomy.