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    Effects of Coenzyme Q10 Supplementation on Plasma Adiponectin, Interleukin-6, and Tumor Necrosis Factor-alpha Levels in Men
    (Mary Ann Liebert, Inc, 2010) Gökbel, Hakkı; Gergerlioğlu, Hasan Serdar; Okudan, Nilsel; Gül, İbrahim; Büyükbaş, Sadik; Belviranlı, Muaz
    The aim of the study was to determine the effects of coenzyme Q10 supplementation on plasma adiponectin, interleukin (IL)-6, and tumor necrosis factor (TNF)-alpha levels in sedentary men. Fourteen healthy, nonsmoking, sedentary men participated in the study. The protocol was approved by the Ethical Committee of our institution. This study was a randomized, double-blind, crossover trial. Blood samples were collected from all participants before coenzyme Q10 or placebo supplementation. The participants were randomly allocated to two groups. Seven participants received oral coenzyme Q10 (100 mg/day) supplementation, and seven participants received placebo (glucose) for 8 weeks. At the end of the 8 weeks, a second blood sampling was performed. After a 4-week washout period, placebo was given to the participants who used coenzyme Q10 the first time, and vice versa, and blood sampling was repeated. Plasma was stored at -80 degrees C until the time of analysis for adiponectin, IL-6, and TNF-alpha. Both CoQ10 and placebo supplementation did not affect plasma adiponectin and TNF-alpha levels. IL-6 level increased with coenzyme Q10 supplementation, but this increase did not differ from that seen with placebo supplementation. Coenzyme Q10 supplementation did not affect plasma adiponectin, IL-6, and TNF-alpha levels in sedentary men.
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    The Serum Levels of Resistin in Ankylosing Spondylitis Patients: A Pilot Study
    (SPRINGER HEIDELBERG, 2012) Kocabaş, Hilal; Kocabaş, Volkan; Büyükbaş, Sadik; Melikoğlu, Meltem Alkan; Sezer, İlhan; Bütün, Bülent
    Resistin is a recently described adipokine which is a member of cysteine-rich secretory protein family. Although it has been primarily defined in human adipocytes, it has been identified that its level was higher in mononuclear leukocytes, macrophages, spleen, and bone marrow cells. Because ankylosing spondylitis is an inflammatory disease, it is suspected that upregulation of proinflammatory cytokines is effective in its immunopathogenesis. The aim of our study is to determine the serum resistin levels in patients with AS and to research the relationship with disease activity markers. A total of 30 patients with AS and 30 healthy controls were included in this study. Serum resistin concentrations, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Bath AS Disease Activity Index (BASDAI) were evaluated. In results resistin levels in ankylosing spondylitis group were significantly higher than in control group. But, there was no correlation between resistin and ESR, CRP, BASDAI. In conclusion, higher serum resistin levels in patients with AS compared to healthy subjects give clues that resistin could have a role in the pathogenesis of AS.