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    Effects of melatonin on the serum levels of pro-inflammatory cytokines and tissue injury after renal ischemia reperfusion in rats
    (TAYLOR & FRANCIS LTD, 2015) Oguz, Elif; Yilmaz, Zehra; Ozbilge, Hatice; Baba, Fusun; Tabur, Suzan; Yerer, Mukerrem Betul; Hekimoglu, Askin
    We investigated the changes in the serum levels of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, the pro-inflammatory cytokines, and the possible effect of melatonin on the modulation of these inflammatory molecules after renal ischemia reperfusion (IR). The study was carried out in the laboratory of Department of Pharmacology. Forty-six male Wistar albino rats were divided into five groups as control (n = 6), positive control (n = 4), sham (n = 12), renal IR (n = 12), and renal IR melatonin (n = 12). After 1 h renal pedicle occlusion, the blood samples were taken for the measurement of cytokine levels at second hour of the reperfusion. The rats were sacrificed after 24 h of reperfusion for histopathological evaluation. Melatonin or vehicle was administrated to IR rats. Lipopolysaccharide (LPS) was administered to the positive control group and the blood was taken at fourth hour. Serum TNF-alpha levels increased significantly in renal IR and LPS groups. Serum IL-6 levels were not different from control except the LPS group. There was no significant correlation between the serum TNF-alpha levels and the histopathological score after renal IR. Melatonin treatment reversed the increase of serum TNF-alpha levels and histopathological injury in renal tissue after renal IR. Melatonin may have a protective effect by reducing the serum level of TNF-alpha in renal IR.
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    Giant papillary carcinoma arising in the ectopic buccal thyroid tissue
    (WILEY, 2013) Elsurer, Cagdas; Ozturk, Kayhan; Baba, Fusun; Yavas, Cagdas; Bulut, Serap
    BackgroundEctopic thyroid tissue very rarely occurs in the buccal region. Even more rarely encountered is the papillary carcinoma arising in the ectopic tissue. Methods and ResultsWe herein present a 78-year-old female patient admitted with a giant, buccal mass that developed within the previous 2 years. Physical examination revealed a vegetative mass on the left buccal region without any cervical lymphadenopathy. Magnetic resonance imaging scan showed an 8- x 6-cm solid mass with cystic components in the left buccal region and thoracic computed tomography scanning revealed pulmonary metastasis. A successful surgery including lower lip splitting was performed, and the mass was totally excised with its surrounding capsule. Histopathologic examination revealed follicular variant of papillary carcinoma of the ectopic thyroid tissue. ConclusionsTo our knowledge, our case is the first case of papillary carcinoma arising from ectopic thyroid tissue in the buccal region in the literature. (c) 2012 Wiley Periodicals, Inc. Head Neck 35: E308-E309, 2013
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    The Potential Effect of Epidural Anesthesia on Mesenteric Injury after Supraceliac Aortic Clamping in a Rabbit Model
    (ELSEVIER SCIENCE INC, 2016) Onoglu, Rasit; Narin, Cuneyt; Kiyici, Aysel; Sarkilar, Gamze; Hacibeyoglu, Gurhan; Baba, Fusun; Sarigul, Ali
    Background: Epidural anesthesia is known to increase blood flow by producing vasodilatation on mesenteric circulation. In this experimental study, we aim to examine the effect of epidural anesthesia on mesenteric ischemic-reperfusion ( IR) injury induced by supracoeliac aortic occlusion in a rabbit model. Methods: Twenty-eight male white New Zealand rabbits were assigned into 4 separate groups, with 7 rabbits in each group: group I, control group; group II, IR-only group; group III, IR plus epidural anesthesia group; group IV, epidural anesthesia-only group. IR model was produced by clamping supraceliac aorta with an atraumatic vascular clamp for 60 min, followed by reperfusion for 120 min. An epidural catheter was placed via Th12-L1 intervertebral space by using open technique before aortic clamping in those assigned to epidural anesthesia. IR injury was assessed using blood markers interleukin-6 and IMA and tissue markers superoxide dismutase and malondialdehyde. Also histopathological examination was performed to evaluate the degree of injury. Results: All biochemical markers in group II were significantly elevated in comparison with the other 3 groups ( p < 0.05). This was paralleled by a more severe histopathological injury in IR-only group ( group II). The group receiving IR plus epidural anesthesia ( group III) had lower biochemical marker levels as compared with the IR-only group ( group II). Conclusions: Mesenteric IR injury that can occur during abdominal aorta surgery can be reduced by epidural anesthesia, which is commonly used during or after major operations for pain control. Controlled clinical studies are required to evaluate these findings.
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    Synchronous, Multiple Primary Lung Cancers: A Report of Three Cases
    (AVES, 2015) Tulek, Baykal; Baba, Fusun; Inan, Esra; Kanat, Fikret; Suerdem, Mecit
    Multiple primary lung cancers (MPLC) are named synchronous if determined simultaneously with the index tumor, and metachronous if the second tumor is diagnosed with an accepted time after the first tumor. It is important for both the rate of survival and treatment alternatives to differentiate synchronous MPLCs from the metastases of the primary lung tumors, and also from the multiple pulmonary metastases of the extra pulmonary tumors. In this study, clinical characteristics, diagnosis and treatment processes of three synchronous MPLC cases diagnosed in our department were assessed.