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Öğe Evaluation of patients with Beh double dagger et's disease by cervical cytology and colposcopic examination(SPRINGER HEIDELBERG, 2012) Ozdemir, Suna; Ozdemir, Mustafa; Celik, Cetin; Balevi, Ali; Toy, Hatice; Kamis, UmitWe evaluated the genital involvement in women with Beh double dagger et's disease (BD) by cervical cytology and colposcopy, and compared these findings with healthy controls. A total of 152 women were referred to the Gynecology Clinic of Meram School of Medicine between March 2008 and December 2009. The study group was composed of 78 women with BD, and the control group included 74 healthy women admitted for routine gynecologic examination. These patients were subjected to cervical cytology and colposcopic examination. Cervical biopsy was performed in cases with abnormal cytology. These findings and some gynecologic complaints were compared. The demographic features were similar between each group. Genital involvement (scar + ulcer) was detected in 58 (74.3%) patients. The most common sites of ulcers (55.1%) and scars (7.6%) were the labia majora. Abnormal cytology in study and control groups was detected in nine (11.5%) and three (4%) of the patients, respectively, and a slight statistical significance was obtained (p = 0.048). Acetowhite and iodine-negative epithelium were higher in the study group than in controls (p = 0.015 and p = 0.042). Dyspareunia was higher in BD patients (p = 0.001). Patients with BD are more prone to having an abnormal cervical cytology and acetowhite and iodine-negative epithelium on colposcopic examination. However, these findings are mostly benign conditions. The complaint of dyspareunia should be considered during treatment of female patients with BD.Öğe Psöriasisli hastalarda serum mmp- 2, mmp-9, NSE, s-100 düzeyleri(Selçuk Üniversitesi Tıp Fakültesi, 2011) Balevi, Ali; Tol, HüseyinPsoriasis patogenezinde nöral etkinin önemi, ilk olarak distal sinirlerde meydana gelen travma sonrasında ilgili alanda psoriasis plaklarında tamamen gerileme meydana gelmesiyle ilişkili vakalar ile anlaşılmaya başlanmıştır. Psoriasis ile periferik sinir lifleri arasındaki ilişkiyi inceleyen çalışmalar son derece sınırlıdır. Çeşitli nörolojik hastalıkların patogenezinde, mmp-2, mmp-9, NSE, s100 markerları rol oynamaktadır. Çalışmamızdaki amaç psoriasis hastalarında periferik sinir liflerini değerlendirmek ve bu markerların psoriasis ile olan ilişkilerini saptamaktı. Materyal ve Metod: Pası skoru 10 ve üzeri olan 25 hasta, pası skoru 10'un altında olan 24 hasta ve 25 sağlıklı kontrol çalışmaya alındı. Her bir hastanın yaş, cinsiyet, aile öyküsü , PASI, tırnak tutulumu ve eklem tutulumu kaydedildi. Çalışmaya alınan tüm olgulara emg testi uygulandı. Markırlar ELİSA yöntemiyle çalışıldı. Bulgular: 3 grup arasında marker düzeyleri açısından fark tesbit edilmedi ancak psoriasisli hastalar ve kontrol grubu arasında yapılan karşılaştırmada; serum mmp-9 düzeyleri psoriasis grubunda yüksek çıkarken, serum NSE ve mmp-2 düzeyleri kontrol grubunda yüksek çıktı. 2 grup arasında s100B düzeyleri açısından fark tesbit edilmedi. Tüm olgularda emg sonuçları normal laboratuar sınırlarındaydı. Sonuç: Çalışmamızdan elde edilen veriler, psöriazisde kalın miyelinli lif tutulumundan çok ince lif nöropatisinin ortaya çıkabileceğini düşündürmektedir. Bu yönde yapılacak araştırmalar, psöriazisde ince lif nöropatisine ışık tuatacaktır.Öğe Psoriasisli Hastalarda Serum Nöroinflamatuvar Belirteç Seviyeleri ve Geniş Çaplı Periferik Sinir Lifi Fonksiyonlarının Değerlendirilmesi(2016) Balevi, Ali; Özdemir, Mustafa; Güney, Figen; Tol, Hüseyin; Okudan, Nilsel; Belviranlı, Muaz; Tahir, KemalAmaç: Günümüzde tümör nekroz faktör-alfa (TNF-?) inhibitörleri, özellikle şiddetli psoriasisin tedavisinde tüm dünyada yaygın olarak kullanılmaktadırlar. Ancak psoriasisli hastalarda TNF-? inhibitör tedavisiyle ilişkilendirilmiş multipl sklerozis (MS) ve periferal nöropatiler bildirilmektedir. Psoriasis tedavisinde kullanılan TNF-? inhibitörleri, altta yatan nörolojik bozukluğu ortaya çıkarıp çıkarmadığı bilinmemektedir. Bu çalışmanın amacı; psoriasis ile multipl sklerozis ve periferal nöropatiler arasında bağlantı olup olmadığını araştırmaktır. Yöntemler: Bu çalışmada; 50 psoriasisli hasta ve 25 sağlıklı kontrol çalışmaya alındı. Nörolojik muayene ve iğne elektromiyografi testleri uygulandı. Nöroinflamatuvar süreçte rol alan matriks metalloproteinaz-2 (MMP-2), matriks metalloproteinaz-9 (MMP-9), S100 kalsiyum bağlayıcı protein (S100B) ve nöron spesifik enolaz (NSE) seviyeleri serumda ölçüldü. Bulgular: Sağlıklı kontrol grubu ile karşılaştırıldığında serum MMP-9 seviyeleri psoriasisli hastalarda yüksek tespit edilirken MMP-2 ve NSE seviyeleri psoriasisli hastalarda, sağlıklı kontrollere göre düşük tespit edildi. Serum S100B seviyeleri açısından her 2 grup arasında fark yoktu. Tüm hastalarda ve sağlıklı kontrollerde tüm nörofizyolojik parametreler normal bulundu ve 2 grup arasında fark tespit edilmedi. Sonuç: NSE ve MMP-9, psoriasisli hastalarda MS'in oluşmasında rol oynuyor olabilir. Özellikle ailesel MS öyküsü olan psoriasisli hastalarda, TNF-? inhibitörü ajan başlamadan önce bu belirteçlerin ölçülmesinin faydalı olabileceğini düşünüyoruz.Öğe Serum Neuroinflammatory Markers' Levels and Evaluation of Peripheral Large Nerve Fibre Function in Patients with Psoriasis(GALENOS YAYINCILIK, 2016) Balevi, Ali; Ozdemir, Mustafa; Guney, Figen; Tol, Huseyin; Okudan, Nilsel; Belviranli, Muaz; Sahin, Kemal TahirObjective: Currently, tumor necrosis factor-alpha (TNF-alpha) inhibitors are widely used all over the world, especially in the treatment of severe psoriasis. However, multiple sclerosis (MS) and peripheral neuropathy occurrence associated with TNF-a inhibitors have been reported in the treatment of patients with psoriasis. It is not known whether TNF-a inhibitors reveal underlying neurological disorders in patients with psoriasis. The aim of this study was to investigate whether there is an association between psoriasis and MS or peripheral neuropathy. Methods: In this study, 50 psoriasis patients and 25 healthy controls were enrolled. Neurological examination and needle electromyography test were performed. Serum levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), S-100 calcium-binding protein (S100B) and neuron specific enolase (NSE), which are involved in neuroinflammatory process, were measured. Results: Serum MMP-9 levels were higher in psoriasis patients compared to healthy controls. Serum MMP-2 and NSE levels were decreased in psoriasis patients compared to healthy controls. There was no significant difference in S100B levels between two groups. All neurophysiological parameters in each individual patient and control were found to be within normal limits and there was no difference between groups. Conclusion: NSE and MMP-9 might play role in the occurrence of MS in psoriasis patients. Especially, we are in the opinion that it might be useful to measure the serum levels of these markers before the administration of TNF-a inhibitors in psoriasis patients with family history of MS.Öğe Öğe Treatment of chronic urticaria with narrowband ultraviolet B phototherapy: a randomized controlled trial(ACTA DERMATO-VENEREOLOGICA, 2008) Engin, Burhan; Oezdemir, Mustafa; Balevi, Ali; Mevlitoglu, InciData regarding narrowband ultraviolet B (NB-UVB) phototherapy in patients with chronic urticaria is limited. The aim of this open, controlled study was to determine whether NB-UVB is effective in treating urticaria in combination with antihistamin. A total of 81 patients with chronic urticaria were recruited, 48 of whom were randomized into the NB-UVB plus antihistamine group. The control group (n = 33) received only antihistamine. Patients were assessed using the urticaria activity score and a visual analogue score (VAS). The 2 groups were evaluated at the same time-points: at treatment sessions 10 and 20 and at follow-up 3 months post-treatment. The reduction in urticaria activity score and VAS was statistically significant (p<0.05 for both groups). When comparing the groups, the mean urticaria activity score was significantly lower in the NB-UVB group at session 10 (22.6 vs. 27.3) and session 20 (17.4 vs. 20.7). Statistically significant differences were also noted in VAS between the 2 groups (p<0.01) at 3 months post-treatment. We conclude that NB-UVB may be an effective complementary treatment for patients with chronic urticaria.Öğe Treatment of Faun-Tail Naevus with Intense Pulsed Light(MARY ANN LIEBERT INC, 2010) Ozdemir, Mustafa; Balevi, Ali; Engin, Burhan; Guney, Figen; Tol, HueseyinBackground: Faun tail is a rare cutaneous marker of spinal dysraphism. This neurological abnormality may lead to difficulties such as severe pain and burning sensations in treatment of hypertrichosis of faun tail with laser or laser-like devices. Objective: We evaluated outcomes of an intense pulsed light source in two patients with faun tail. Methods: The Lumina intense pulsed light system [650-nm handpiece (550-1100 nm)] was used for the treatment. Magnetic resonance imaging and neurological examination were done. Results: Tethered cord syndrome was detected as a neurological abnormality. The patients were treated with an energy fluence of 18-26 J/cm(2), pulse sequencing of 3 to 4, and a delay time of 20-35 ms. Local anesthesia was applied in one patient during treatment for severe pain sensation. A mean of 85% hair reduction was achieved. Conclusion: A good cosmetic result with intense pulsed light treatment was achieved in the patients with faun tail. Local anesthesia may be required before treatment of faun tail with laser or laser-like systems due to associated neurological abnormalities.Öğe What is Your Diagnosis?(TURKISH SOC DERMATOLOGY VENEROLOGY, 2011) Ozdemir, Mustafa; Balevi, Ali[Abstract not Available]
