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    Effects of magnesium sulfate on Na+,K+ -ATPase and intracranial pressure level after cerebral ischemia
    (2004) Ustun M.E.; Bariskaner H.; Yosunkaya A.; Gurbilek M.; Dogan N.
    In the present study, the effects of magnesium sulfate on Na +,K+-ATPase levels and intracranial pressure (ICP) after cerebral ischemia in rabbits were studied. Thirty New Zealand rabbits were divided into three groups. Group 1 was the control group. In group 2 (untreated group) cerebral ischemia was produced by clamping bilateral common carotid arteries for 60 min but in group 3 magnesium sulfate was administered 100 mg/kg i.v. 10 min after opening the clamps. In group 1, ICP recordings were obtained 5, 60 and 120 min after craniectomy. In groups 2 and 3, ICP recordings were obtained 5 min after craniectomy but before clamping, 60 min after clamping and 60 min after opening the clamps. After taking ICP recordings, brain cortices were resected and Na+,K+-ATPase activity was determined by subtracting the enzyme activity in the presence of ouabain from the total activity in the absence of ouabain method. There was a significant difference between Na+,K+-ATPase levels of group 1 and group 2 (P < 0.05). There was no significant difference in Na+,K +-ATPase levels between group 1 and 3 (P > 0.05), also preischemic ICP values were same in all groups (P > 0.05). Preischemic and postischemic ICP values were significantly different between groups 1 and 2 (P < 0.05), also postischemic (120 min) ICP values were significantly different between group 2 and group 3 (P < 0.05). ICP values correlate well with Na +,K+-ATPase level. These results demonstrate that cerebral ischemia leads to a decrease of ATPase level in the brain and magnesium sulfate suppresses the decrease of Na+,K+-ATPase, also magnesium sulfate treatment improves the ICP changes.
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    In vitro vasoactive effects of dexmedetomidine on isolated human umbilical arteries
    (COMENIUS UNIV, 2019) Arun, O.; Taylan, S. B.; Duman, I; Oc, B.; Yilmaz, S. A.; Tekin, A.; Celik, C.; Bariskaner H.; Celik J. B.
    OBJECTIVE: We aimed to investigate the vasoactive effects of dexmedetomidine on isolated human umbilical arteries and possible mechanisms involved. METHODS: Human umbilical artery strips were suspended in Krebs-Henseleit solution and dose-response curves were obtained for cumulative dexmedetomidine before and after incubation with different agents; propranolol, atropine, yohimbine, prazosin, indomethacin, verapamil. Effects of calcium on cumulative dexmedetomidine-induced contractions were also studied. RESULTS: Cumulative dexmedetomidine resulted in dose dependent contraction responses. Incubation with propranolol (Emax: 93.3 +/- 3.26 %), atropine (Emax: 92.0 +/- 6.54 %), or indomethacin (Emax: 94.25 +/- 2.62 %), did not attenuate dexmedetomidine-elicited contractions (p > 0.05). There were significant decreases in the contraction responses of cumulative dexmedetomidine with yohimbine (Emax: 12.1 +/- 11.9 %), prazosin (Emax: 28.8 +/- 4.6 %) and verapamil (Emax: 11.2 +/- 13.6 %) (p < 0.05). In Ca+2 free medium contraction responses to cumulative dexmedetomidine was insignificant (Emax: 5.20 +/- 3.42 %). Addition of cumulative calcium to the Ca+2 free medium resulted in concentration dependent increase in contractions (Emax: 64.83 +/- 37.7 %) (p < 0.05). CONCLUSION: Dexmedetomidine induces vasoconstriction in endothelial-free umbilical arteries via both, alpha(1)- and alpha(2)-adrenergic receptors and also extracellular Ca+2 concentrations play a major role. beta-adrenergic receptors, muscarinic cholinergic receptors, and inhibition of cyclooxygenase enzyme are not involved in this vasoconstriction (Fig. 3, Ref. 36). Text in PDF www.elis.sk.
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    The usage of tramadol hydrochloride in intraoperative and early postoperative analgesia [Intraoperatif ve erken postoperatif analjezide tramadol hidroklorid kullanimi]
    (1999) Tuncer S.; Bariskaner H.; Aydemir T.; Yosunkaya A.; Otelcioglu S.
    Tramadol hydrochlorid (TH), a synthetic opioid, is an efficient analgesic. But there are various views on its usage in anaesthesia. In this study, the efficiency of TH in intraoperative and early postoperative analgesia, its effect to hemodynamic parameters and its side effects were studied. Premedication with 10 mg diazepam, 0.5 mg atropine was applied to 20 cases from the group of ASA I-II which would undergo elective gynaecological laporoscopic surgery. Anaesthesia induction was provided by 5 mg/kg thiopental, 1.5 mg/kg TH and 1.5 mg/kg sucsynilcholine and also continuation was provided by 2-2.5 % sevoflurane. Atracurium was added when necessary. When insufficient anaesthesia symptoms were seen. 25 mg. TH was added. With the aim of postoperative analgesia, 1.5 mg/kg TH was applied to the cases in the waking up room. As a result, when TH is added to anaesthesia, it can be tolerated very well in the depth of anaesthesia and providing sufficient analgesia and we believe that it will be used safely due to its minimal side effects and the immediate recovery it provides, especially in daily surgery.