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Öğe The effects of CoQ10 on the erythrocyte and liver tissue cholinesterase, NO and MDA levels in the acute organophosphate toxicity(ELSEVIER IRELAND LTD, 2011) Bayir, A.; Kara, H.; Koylu, O.; Kocabas, R.; Ak, A.[Abstract not Available]Öğe The effects of melatonin on erythrocyte and brain cholinesterase, nitric oxide and MDA levels in acute organophosphate toxicity(ELSEVIER IRELAND LTD, 2011) Bayir, A.; Kara, H.; Koylu, O.; Kocabas, R.; Ak, A.[Abstract not Available]Öğe The effects of melatonin on erythrocyte and renal tissue cholinesterase, nitric oxide and MDA levels in acute organophosphate toxicity(ELSEVIER IRELAND LTD, 2011) Bayir, A.; Kara, H.; Koylu, O.; Kocabas, R.; Ak, A.[Abstract not Available]Öğe The effects of N-acetylcysteine on the erythrocyte and lung tissue cholinesterase, nitric oxide and malondialdehyde levels in acute organophosphate toxicity(ELSEVIER IRELAND LTD, 2011) Bayir, A.; Kara, H.; Koylu, O.; Kocabas, R.; Ak, A.[Abstract not Available]Öğe The effects of ubiquinone (CoQ10) on heart tissue in cardiac toxicity related to organophosphate poisoning(SAGE PUBLICATIONS LTD, 2013) Bayir, A.; Kara, H.; Koylu, O.; Kocabas, R.; Ak, A.The aim of this study was to examine the effects of ubiquinone (CoQ10) on heart tissue and erythrocytes in acute organophosphate poisoning (AOP). A total of 20 rabbits were divided into three groups: sham (n = 8), pralidoxime (PAM) + atropine (n = 6), and CoQ10 + PAM + atropine (n = 6). Blood samples were taken from each test subject to measure the values of acetylcholinesterase (AChE), nitric oxide (NO), and malondialdehyde (MDA) in the plasma and erythrocyte before administration of 50 mg/kg dichlorvos by orogastric tube. Blood samples were then taken at 1, 12, and 24 h post-dichlorvos to determine plasma and erythrocyte levels of AChE, NO, and MDA. Sham group received no treatment. PAM + atropine group received 0.05 mg/kg atropine with repeated doses and PAM: first a 30-mg/kg intravenous (IV) bolus, then a 15-mg/kg IV bolus every 4 h. CoQ10 + PAM + atropine group received same dose PAM and atropine and a 50-mg bolus of IV CoQ10. Thoracotomy was performed in all the animals 24 h after poisoning and then heart tissue samples were obtained. At 12 and 24 h, erythrocyte AChE levels in the CoQ10 animals were considerably higher than those in PAM + atropine animals (p = 0.023 and 0.017, respectively). At 12 and 24 h, erythrocyte MDA and NO levels in CoQ10 animals were significantly lower than those in PAM + atropine animals (p < 0.05). Heart tissue AChE levels in CoQ10 animals were considerably higher than those of the sham and PAM + atropine animals (p = 0.001). Heart tissue MDA and NO levels of CoQ10 animals were significantly lower than those of the sham and PAM + atropine animals (p < 0.01). Treatment of AOP with CoQ10 + PAM + atropine in this animal model had a beneficial effect on both erythrocyte and heart tissue lipid peroxidation and AChE activity.Öğe The effects of vitamin E on the erythrocyte and heart tissue cholinesterase, NO and MDA levels in the acute organophosphate toxicity(ELSEVIER IRELAND LTD, 2011) Bayir, A.; Kara, H.; Koylu, O.; Kocabas, R.; Ak, A.[Abstract not Available]Öğe Pulmonary embolism severity index, age-based markers and evaluation in the emergency department(MANEY PUBLISHING, 2015) Kara, H.; Degirmenci, S.; Bayir, A.; Ak, A.Objectives: The purpose of this study was to assess the severity of pulmonary embolism in the emergency department using vital signs and age-based vital parameters and compare these parameters with pulmonary embolism severity index (PESI) score. Methods: Between January 2011 and October 2014, there were 284 patients diagnosed with pulmonary embolism in the Emergency Unit of Selcuk University Hospital. Patient records were reviewed retrospectively. The PESI scores were calculated, and patients were divided into high-and low-risk groups. Shock index (SI), age-based shock index (SIA), maximum heart rate (MHR), minpulse (MP) and pulse maximum index (PMI) were calculated. The association of these parameters with PESI was evaluated. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the association of risk and mortality with age-based markers. Results: There were 75 men (43%) in the 173 patients included in the study. The PESI classification showed 54 patients in the low-risk group and 119 patients in the high-risk group. Mortality was higher in the PESI high-risk group, and no deaths occurred in the low-risk group. Comparison of the age-based markers and PESI for patients who died or survived showed that AUC for PESI was 0.807, AUC for SI was 0.824 and AUC for SIA was 0.825. Conclusions: The SIA risk classification was more efficient than SI in pulmonary embolism patients who presented to the emergency unit. The SIA was more accurate than SI or PESI in predicting mortality.Öğe Vitamins and coronary artery disease(WAGENINGEN ACAD PUBL, 2017) Bayir, A.Cardiovascular diseases are the leading causes of mortality and morbidity in developed and developing countries all over the world. Atherosclerosis is the most important preparation factor in the development of coronary ischemia. It is known that vitamins play an important role in the regulation of numerous pathological events such as endothelial damage, reactive oxygen species due to oxidative damage, platelet dysfunction, platelet aggregation, leukocyte adhesion and vasoconstriction that are among the most important pathogenetic mechanisms in the development of acute cardiac ischemic diseases. Acute coronary vascular events can be prevented by adequate intake of these vitamins, regulation of nutrition to meet the need for vitamins, or exogenous supplementation to supplement daily needs.
