Yazar "Bayraktar, Nihayet" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    Investigation of cytokines, biochemical parameters and oxidative stress levels in serum of patients with acute pancreatitis
    (Selçuk Üniversitesi, 2024) Bayraktar, Nihayet; Aslan, Oruç; Uyanıkoğlu, Ahmet; Öztürk, Ali; Bayraktar, Mehmet; Erdoğdu, Hamza
    Objective: This study aimed to find new serum biochemistry parameters, especially for the early identification of severe Acute Pancreatitis (AP). In the study, serum cytokine levels (TNF-A, IL-1, IL 6, IL-10, IL-21), biochemical parameters (Aquaporin-1, Hepcidine, Iron, Zinc, Copper, Nitric Oxide, C-Reactive protein) and oxidative stress parameters analysis were performed. Method: A total of 46 patients with AP and 46 healthy controls were included in this study. Serum cytokine levels, biochemical, and oxidative stress parameters by the ELISA method and CRP by the immunoturbidimetric method were measured. Results: When patients with AP and control groups were compared, all studied parameters were found statistically significant (p0.05). Therefore, the Mann Whitney U test, which is a non-parametric test, was deemed appropriate to determine whether there was a significant difference between the patient and control groups. Conclusions: Investigating the role of cytokines, oxidative stress and other biochemical parameters in the pathogenesis and course of the disease may contribute to a better understanding of the disease process and its therapeutic value. It showed a significant increase in oxidative stress parameters and biochemical parameters such as aquaporin-1, hepcidin, lipase, and amylase, which may help in the diagnosis of AP.
  • Küçük Resim Yok
    Öğe
    The levels of nitric oxide in megaloblastic anemia
    (AVES YAYINCILIK, 2009) Erkurt, Mehmet Ali; Aydogdu, Ismet; Bayraktar, Nihayet; Kuku, Irfan; Kaya, Emin
    Objective: The purpose of this study was to investigate the relationship between nitric oxide degradation products (nitrate and nitrite) levels and megaloblastic anemia which is treated with cyalocobalamin. Materials and Methods: A total of 30 patients with megaloblastic anemia (16 Male, 14 Female) were included in the study, Cyanocobalamin was administered (1.000 mu g/day intramuscularly) until the reticulocyte crisis occurred to the normal range. The control group consisted of 30 healthy subjects (15 Male, 15 Female). Nitric oxide levels were measured before treatment and compared with the values obtained during peak reticulocyte count. Results: Plasma direct nitrite, total nitrite and nitrate levels were 24,86 +/- 3,87, 60.56 +/- 7,01 and 36,02 +/- 5,24 in before treatment versus 15,48 +/- 3,05, 38,92 +/- 6,44 and 22,77 +/- 6,04 mu mol/dl in after treatment, respectively, Plasma direct nitrite, total nitrite and nitrate levels were significantly lower in after treatment compared with the before treatment (p<0.001). Conclusion: Nitric oxide levels are seen to increase in megaloblastic anemia. This study suggested that abnormalities in the nitric oxide levels in megaloblastic anemia are restored by vitamin B12 replacement therapy. (Turk J Hematol 2009; 26: 197-200)