Yazar "Bilgiç, Özlem" seçeneğine göre listele
Listeleniyor 1 - 14 / 14
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Are 2D:4D finger-length ratios an indicator of androgenetic alopecia in males?(SOC BRASILEIRA DERMATOLOGIA, 2016) Bilgiç, Özlem; Altınyazar, Hilmi Cevdet; Eryılmaz, Dilek; Tuğrul, Zehra AyçaBACKGROUND: Although the pathogenesis of androgenetic alopecia is not completely understood, the roles of genetic susceptibility and androgens are well-known. A lower ratio of the second digit (index finger = 2D) to the fourth digit (ring finger = 4D) length has been hypothesized to reflect prenatal androgen exposure and/or higher sensitivity to androgens. OBJECTIVES: To determine the relationship between the second to fourth digit length ratio and androgenetic alopecia. METHODS: Finger length measurements were made by a digital vernier calliper. Androgenetic alopecia severity was assessed using the Hamilton-Norwood scale. Subjects with an androgenetic alopecia score of grade III or more were included in the study. RESULTS: A total of 189 males with androgenetic alopecia and 171 healthy controls were enrolled in the study. The age range of participants was 19-65 years. The 2D:4D ratios in patients with androgenetic alopecia were significantly lower than those of healthy controls for the right hand; however, no significant difference was found for the left hand. Average 2D:4D ratios in androgenetic alopecia patients were also lower than in controls. No significant relationship was observed between androgenetic alopecia severity and 2D:4D ratios. CONCLUSION: Our data support the anatomical evidence of in utero androgen exposure and/or an individual's sensitivity to androgens in patients with androgenetic alopecia. Furthermore, the right hand 2D:4D ratio might be an indicator of androgenetic alopecia development.Öğe Association between endocrinological, immunological and psychosocial variables in psoriasis patients(EDIZIONI MINERVA MEDICA, 2016) Bilgiç, Özlem; Bilgiç, Ayhan; Sivrikaya, Abdullah; Selvi, Yavuz; Ünlü, Ali; Altınyazar, Hilmi CevdetBACKGROUND: There is limited data concerning the relationship between psychosocial problems of psoriasis patients and the function of their hypothalamic-pituitary-adrenal (IPA) axis and immunologic markers. This study aimed to determine serum levels of basal cortisol and adrenocorticotropic hormone (ACTH) and circulating levels of various cytokines and chemokines and their association with psychological measures in psoriasis patients. METHODS: Serum concentrations of endocrinological and immunological variables were quantified, and psychiatric questionnaires were completed. RESULTS: In psoriasis patients, serum levels of ACTH, TNF-a, IL-6, IL-23, CCL-17, CCL-27, CCL-20 and CXCL-9, current psychiatric symptoms and childhood neglect scores were all higher than in controls. In addition, in psoriasis patients, physical neglect scores were related to lower basal cortisol, whereas recent stressful life events were related to higher IL-6, IL-23 and CCL-20 levels. CONCLUSIONS: The exposure to stressful life events in childhood and just before a flare-up of psoriasis may be related to altered function of the HPA axis and an immune dysregulation in psoriasis.Öğe Beaded Papules Along the Eyelid Margins(QUADRANT HEALTHCOM INC, 2016) Bilgiç, Özlem; Hira, Hüseyin; Altınyazar, Hilmi Cevdet; Karabağlı, Pınar[Abstract not Available]Öğe Case report of metastatic calcinosis cutis: A different localization(Turkiye Klinikleri, 2014) İslamoğlu, Zeynep Gizem Kaya; Bilgiç, Özlem; Karabağlı, Pınar; Altınyazar, Hilmi CevdetCalcinosis cutis is characterized by deposition of insoluble calcium salts in the skin and subcutaneous tissue. Based on the etiology of calcium deposition in the skin, calcinosis cutis is divided into four groups including: dystrophic, metastatic, iatrogenic, idiopathic. Metastatic calcification is described as precipitation of calcium salts in normal tissues because of hyperphosphatemia or hypercalcemia and it may be associated with conditions such as chronic renal failure, neoplasms, sarcoidosis, hyperparathyroidism, hypervitaminosis D. Metabolic renal failure is the most common cause of metastatic calcification. Diagnosis is put together with clinical and histopathological correlation. The mainstay of treatment is resolved of the underlying disease. Here a patient is presented with calcified plaque lesions on the bilateral axillary region for two months who is undergoing hemodialysis seven years due to chronic renal failure and uses crutches for four months because of traffic accidents. Copyright © 2014 by Türkiye KlinikleriÖğe Çocuklarda Nadir Görülen Bir Hastalık: Goltz Sendromu(2016) Güvenç, Osman; Bilgiç, Özlem; Çimen, Derya; Aslan, Eyüp; Arslan, Derya; Oran, BülentGoltz sendromu (Fokal dermal hipoplazi), mezoektodermal dokuyu tutan ve çok nadir görülen bir hastalıktır. Deri lezyonları ile birlikte iskelet sistemi, dental ve oküler anomaliler, hastaların az bir kısmında da kalp ve böbrek anomalileri görülebilmektedir. Makalede, Goltz sendromu tanısı alan, biküspit aort kapağı ve buna bağlı aort kapak darlığı ve yetmezliği olan beş yaşındaki kız hasta olgu olarak sunuldu ve seyrek görülen bu hastalık, son literatür bilgileri eşliğinde tartışıldı.Öğe Hiperhidrozis tedavisi(2014) Apilioğulları, Burhan; Bilgiç, ÖzlemHiperhidrozis, patolojik kabul edilebilecek kadar ciddi, lokalize veya genel, aşırı terleme ile karakterize bir durumdur. Bu durum ha- yatın sosyal ve mesleki kalitesi üzerinde olumsuz etki eden önemli bir stres kaynağı olabilir. Eller, koltuk altı, ayaklar ve yüzü etkileyen primer hiperhidrozisin tedavisi hakkında tartışmalar mevcuttur. Cerrahi olmayan tedavi, topikal ilaçlar, iyontoforez ve sistemik anti- kolinerjikleri içerir. Son zamanlarda, intradermal botulinum toksini kullanımı popülarite kazanmıştır. Günümüzde, torasik sempatik cerrahi uygulaması primer hiperhidrozisli hastalar için altın standarttır.Öğe Investigation of the Association of the Second-to-Fourth Digit Ratio with Skin Sebum Levels in Females with Acne Vulgaris(ADIS INT LTD, 2015) Bilgiç, Özlem; Altınyazar, Hilmi Cevdet; Hira, Hüseyin; Doğdu, MuratBackground A relationship between acne vulgaris (AV) and the masculinized (lower) second-to-fourth digit (2D:4D) ratio in females was demonstrated in our previous study. Development of the digits and the sebaceous glands both occur during the same gestational period; therefore, the association between the 2D:4D ratios and AV may result from the effects of the prenatal endocrine environment on the sebaceous glands. Objective The aim of this study was to evaluate the relationship between the 2D:4D ratio and sebum levels in the skin of females with AV. Methods In total, 215 female AV patients and 92 healthy controls, aged 18-35 years, were enrolled in this study. Finger-length measurements were made using a digital Vernier caliper, and the sebum levels of five facial areas were measured using a Sebumeter SM 815. Acne severity was assessed using the International Consensus Conference on Acne Classification System. Results The 2D:4D ratios of the AV patients were significantly lower than those of the controls, for both hands. The mean sebum levels in the T-zone, U-zone and whole face were significantly higher for AV patients compared with controls. The 2D:4D ratio in the left hand showed significant negative correlations with the sebum levels in the U-zone; however, no association was found between the 2D:4D ratios and sebum levels in the T-zone and whole face. While acne severity was positively correlated with skin sebum levels, no correlation between acne severity and 2D:4D ratios was observed. Conclusion This study provides preliminary evidence regarding the association between lower 2D:4D ratios and higher rates of sebum secretion in the U-zone for females with AV. The 2D:4D ratio might be a predictor of sebum levels, as well as acne development, in females.Öğe Olası trastuzumab kullanımına bağlı gelişen pyojenik granülom(2013) Bilgiç, Özlem; Altınyazar, Hilmi CevdetSon yıllarda, insan epidermal reseptörü (HER)'nü hedefleyen ilaçlar solid tümörlerin tedavisinde başarılı bir şekilde kullanılmaya başlamıştır. HER 1 inhibitörlerine bağlı çok sayıda kutanöz yan etki bildirilmiş olmasına rağmen, HER 2 ile ilişkili spesifik kutanöz yan etki nadir olarak bildirilmiştir. Trastuzumab HER 2'ye yönelik rekombinant monoklonal bir antikordur ve erken ve metastatik meme kanseri için kullanılmaktadır. Burada meme kanseri için üç haftada bir aldığı trastuzumab tedavisinin onbirinci küründen sonra sol kulak memesinde piyojenik granülom gelişen 47 yaşında bir kadın olgu sunulmaktadırÖğe Pseudo Darier Sign: A Distinctive Finding for Congenital Smooth Muscle Hamartoma(MOSBY-ELSEVIER, 2016) Bilgiç, Özlem; Akyürek, Fatma Tunçez; Altınyazar, Hilmi Cevdet[Abstract not Available]Öğe Relationship between acne vulgaris and attention-deficit/hyperactivity disorder symptoms in a clinical sample of women(SOC BRASILEIRA DERMATOLOGIA, 2016) Bilgiç, Ayhan; Bilgiç, Özlem; Çolak, Rukiye Sivri; Altınyazar, Hilmi CevdetAcne vulgaris has recently been reported to be associated with elevated rates of attention deficit/hyperactivity disorder in epidemiological studies. This report examines childhood and current attention-deficit/hyperactivity disorder symptoms in a clinical sample of female adults. Ninety-one women with acne vulgaris and 53 controls were included in this study. The aforementioned symptoms were measured in participants. No significant differences were found between patients and controls in any of the measurements. Contrary to the findings of epidemiological studies, this study did not uncover a link between acne vulgaris and attention-deficit/hyperactivity disorder.Öğe The relationship between erythrocyte zinc levels and isotretinoin use in acne vulgaris patients(TAYLOR & FRANCIS LTD, 2015) Bilgiç, Özlem; Altınyazar, Hilmi Cevdet; Sivrikaya, Abdullah; Ünlü, AliBackground: Prior studies have demonstrated lower serum zinc levels in acne vulgaris (AV) patients compared with controls. However, no study has investigated the relationship between AV and erythrocyte zinc levels, which is a superior indicator of body zinc levels. Additionally, the potential influence of isotretinoin use on body zinc status remains to be evaluated. In this study, we aimed to determine erythrocyte zinc levels and their relationship with isotretinoin use in AV patients. Methods: The enrolled study participants included 106 (68% female) isotretinoin-treated AV patients, 89 (65% female) untreated AV patients and 100 (59% female) healthy volunteers between 18 and 30 years of age. The acne severity of the AV patients who did not receive treatment was assessed using the classification system of the International Consensus Conference on Acne. Erythrocyte zinc levels were analysed by atomic absorption spectroscopy. Results: No significant differences were observed among the three groups with respect to erythrocyte zinc levels. In addition, erythrocyte zinc levels did not vary according to the severity of AV, nor according to the duration of isotretinoin use. Conclusion: This study suggests that no relationships exist among zinc status, AV and isotretinoin use. However, given the relationship between vitamin A and zinc, and the fact that previous studies have indicated low serum zinc levels in AV patients, prospective studies are required to corroborate our data.Öğe Relationship between sleep quality and facial sebum levels in women with acne vulgaris(MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2016) Bilgiç, Özlem; Bilgiç, Ayhan; Altınyazar, Hilmi Cevdet[Abstract not Available]Öğe Serum homocysteine, asymmetric dimethyl arginine (ADMA) and other arginine-NO pathway metabolite levels in patients with psoriasis(SPRINGER, 2015) Bilgiç, Özlem; Altınyazar, Hilmi Cevdet; Baran, Hatice; Ünlü, AliHyperhomocysteinemia, a well-known and independent risk factor for cardiovascular disease, has been related in several studies with psoriasis patients. It has been suggested that homocysteine leads to endothelial dysfunction by causing an accumulation of asymmetrical dimethyl arginine (ADMA), a potent endogenous nitric oxide (NO) synthase inhibitor of the l-arginine-NO pathway. However, limited data is available regarding the psoriasis and ADMA relationship. In this study, we aimed to investigate the serum levels of homocysteine, ADMA and other metabolites from the l-arginine-NO pathway in psoriasis patients. Forty-two patients with chronic plaque psoriasis and 48 controls were enrolled in the study. Serum homocysteine, ADMA, l-monomethyl-l-arginine (l-NMMA), symmetric dimethylarginine (SDMA) and l-arginine levels, and l-arginine/ADMA ratios of psoriasis patients and the control group were measured. The severity of psoriasis was assessed by the psoriasis area and severity index (PASI). The mean ADMA and homocysteine values were significantly higher, and citrulline and l-arginine/ADMA values were significantly lower in psoriasis patients compared to control subjects. However, there were no significant differences among the patient and control groups with respect to mean SDMA, l-NMMA and l-arginine values. PASI scores strongly correlated with the ADMA level and moderately correlated with l-arginine/ADMA ratio. This study suggests that the l-arginine-NO pathway metabolites, especially ADMA, may play an important role in the pathogenesis of psoriasis. Additionally, serum ADMA levels of psoriasis patients may be an indicator of the disease severity.Öğe Serum levels of TWEAK in patients with psoriasis vulgaris(ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2016) Bilgiç, Özlem; Sivrikaya, Abdullah; Toker, Aysun; Ünlü, Ali; Altınyazar, Hilmi CevdetTumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) has been implicated in the pathogenesis of a variety of inflammatory disorders and autoimmune diseases. However, studies conducted on the relationship of TWEAK and psoriasis patients are limited. In this study, we aimed to explore the serum levels of TWEAK and investigated whether TWEAK levels are associated with clinical variables and expression of other well-known psoriasis-related cytokines including IL-6, IL-23 and TNF-alpha. Fortyfive patients with chronic plaque psoriasis and 43 controls were enrolled in this study. The severity of psoriasis was assessed by the Psoriasis Area and Severity Index (PASI). Serum levels of cytokines were measured using commercial enzyme-linked immunosorbent assay (ELISA) kits. The mean TWEAK, IL-6, IL-23, and TN-alpha levels were significantly higher in psoriasis patients than in control subjects. However, there were no significant correlations between the psoriasis severity, the illness duration and serum cytokine levels. This study shows that TWEAK may be associated with the pathogenesis of psoriasis, like TNF-alpha, IL-6, and IL-23. (C) 2015 Elsevier Ltd. All rights reserved.
