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Öğe Are 2D:4D finger-length ratios an indicator of androgenetic alopecia in males?(SOC BRASILEIRA DERMATOLOGIA, 2016) Bilgic, Ozlem; Altinyazar, Hilmi Cevdet; Eryilmaz, Dilek; Tugrul, Zehra AycaBACKGROUND: Although the pathogenesis of androgenetic alopecia is not completely understood, the roles of genetic susceptibility and androgens are well-known. A lower ratio of the second digit (index finger = 2D) to the fourth digit (ring finger = 4D) length has been hypothesized to reflect prenatal androgen exposure and/or higher sensitivity to androgens. OBJECTIVES: To determine the relationship between the second to fourth digit length ratio and androgenetic alopecia. METHODS: Finger length measurements were made by a digital vernier calliper. Androgenetic alopecia severity was assessed using the Hamilton-Norwood scale. Subjects with an androgenetic alopecia score of grade III or more were included in the study. RESULTS: A total of 189 males with androgenetic alopecia and 171 healthy controls were enrolled in the study. The age range of participants was 19-65 years. The 2D:4D ratios in patients with androgenetic alopecia were significantly lower than those of healthy controls for the right hand; however, no significant difference was found for the left hand. Average 2D:4D ratios in androgenetic alopecia patients were also lower than in controls. No significant relationship was observed between androgenetic alopecia severity and 2D:4D ratios. CONCLUSION: Our data support the anatomical evidence of in utero androgen exposure and/or an individual's sensitivity to androgens in patients with androgenetic alopecia. Furthermore, the right hand 2D:4D ratio might be an indicator of androgenetic alopecia development.Öğe Association between endocrinological, immunological and psychosocial variables in psoriasis patients(EDIZIONI MINERVA MEDICA, 2016) Bilgic, Ozlem; Bilgic, Ayhan; Sivrikaya, Abdullah; Selvi, Yavuz; Unlu, Ali; Altinyazar, Hilmi C.BACKGROUND: There is limited data concerning the relationship between psychosocial problems of psoriasis patients and the function of their hypothalamic-pituitary-adrenal (IPA) axis and immunologic markers. This study aimed to determine serum levels of basal cortisol and adrenocorticotropic hormone (ACTH) and circulating levels of various cytokines and chemokines and their association with psychological measures in psoriasis patients. METHODS: Serum concentrations of endocrinological and immunological variables were quantified, and psychiatric questionnaires were completed. RESULTS: In psoriasis patients, serum levels of ACTH, TNF-a, IL-6, IL-23, CCL-17, CCL-27, CCL-20 and CXCL-9, current psychiatric symptoms and childhood neglect scores were all higher than in controls. In addition, in psoriasis patients, physical neglect scores were related to lower basal cortisol, whereas recent stressful life events were related to higher IL-6, IL-23 and CCL-20 levels. CONCLUSIONS: The exposure to stressful life events in childhood and just before a flare-up of psoriasis may be related to altered function of the HPA axis and an immune dysregulation in psoriasis.Öğe Beaded Papules Along the Eyelid Margins(QUADRANT HEALTHCOM INC, 2016) Bilgic, Ozlem; Hira, Huseyin; Altinyazar, Hilmi Cevdet; Karabagli, Pinar[Abstract not Available]Öğe Do you know this syndrome? Werner syndrome(SOC BRASILEIRA DERMATOLOGIA, 2017) Bilgic, OzlemWerner syndrome is a rare autosomal recessive disorder, caused by mutations in the WRN gene. Clinical findings include: senile appearance, short stature, grey hair, alopecia, bird-like face, scleroderma-like skin changes, skin ulcers, voice abnormalities, cataracts, osteoporosis, type 2 diabetes mellitus, ischemic heart disease and hypogonadism. The syndrome begins to become apparent in adolescence but it is usually diagnosed in the third or fourth decade of life. Since the patients usually die by the age of 40-50 years related to malignant neoplasms or atherosclerotic complications, they should be closely followed and treated for complications.Öğe Investigation of the Association of the Second-to-Fourth Digit Ratio with Skin Sebum Levels in Females with Acne Vulgaris(ADIS INT LTD, 2015) Bilgic, Ozlem; Altinyazar, Cevdet; Hira, Huseyin; Dogdu, MuratBackground A relationship between acne vulgaris (AV) and the masculinized (lower) second-to-fourth digit (2D:4D) ratio in females was demonstrated in our previous study. Development of the digits and the sebaceous glands both occur during the same gestational period; therefore, the association between the 2D:4D ratios and AV may result from the effects of the prenatal endocrine environment on the sebaceous glands. Objective The aim of this study was to evaluate the relationship between the 2D:4D ratio and sebum levels in the skin of females with AV. Methods In total, 215 female AV patients and 92 healthy controls, aged 18-35 years, were enrolled in this study. Finger-length measurements were made using a digital Vernier caliper, and the sebum levels of five facial areas were measured using a Sebumeter SM 815. Acne severity was assessed using the International Consensus Conference on Acne Classification System. Results The 2D:4D ratios of the AV patients were significantly lower than those of the controls, for both hands. The mean sebum levels in the T-zone, U-zone and whole face were significantly higher for AV patients compared with controls. The 2D:4D ratio in the left hand showed significant negative correlations with the sebum levels in the U-zone; however, no association was found between the 2D:4D ratios and sebum levels in the T-zone and whole face. While acne severity was positively correlated with skin sebum levels, no correlation between acne severity and 2D:4D ratios was observed. Conclusion This study provides preliminary evidence regarding the association between lower 2D:4D ratios and higher rates of sebum secretion in the U-zone for females with AV. The 2D:4D ratio might be a predictor of sebum levels, as well as acne development, in females.Öğe Possible atomoxetine-induced vitiligo: a case report(SPRINGER WIEN, 2015) Bilgic, Ozlem; Bilgic, AyhanVitiligo is a chronic skin disease characterized by the appearance of white depigmented lesion due to a loss of melanocytes. The etiopathogenesis of vitiligo is not clear, but according to the neural theory of vitiligo, the direct and indirect effects of monoamine neurotransmitters cause melanocyte destruction and various studies have supported this theory. Many drugs have been related to the development of vitiligo, and the melanocytotoxic effects of the some of these drugs are thought to be related due to their effects on the monoaminergic system. Furthermore, a recent article reported the development of a localized loss of pigmentation after the application of a methylphenidate patch in a patient with attention-deficit/hyperactivity disorder (ADHD). Atomoxetine is an inhibitor of norepinephrine reuptake sites and is a drug that has been used for the treatment of ADHD. Here, we present a school-aged child with ADHD who displayed a vitiligo lesion following the initiation of atomoxetine. We further discuss the possible impact of the ADHD drugs on the development of vitiligo.Öğe Pseudo Darier Sign: A Distinctive Finding for Congenital Smooth Muscle Hamartoma(MOSBY-ELSEVIER, 2016) Bilgic, Ozlem; Akyurek, Fatma Tuncez; Altinyazar, Hilmi Cevdet[Abstract not Available]Öğe Relationship between acne vulgaris and attention-deficit/hyperactivity disorder symptoms in a clinical sample of women(SOC BRASILEIRA DERMATOLOGIA, 2016) Bilgic, Ayhan; Bilgic, Ozlem; Colak, Rukiye Sivri; Altinyazar, Hilmi CevdetAcne vulgaris has recently been reported to be associated with elevated rates of attention deficit/hyperactivity disorder in epidemiological studies. This report examines childhood and current attention-deficit/hyperactivity disorder symptoms in a clinical sample of female adults. Ninety-one women with acne vulgaris and 53 controls were included in this study. The aforementioned symptoms were measured in participants. No significant differences were found between patients and controls in any of the measurements. Contrary to the findings of epidemiological studies, this study did not uncover a link between acne vulgaris and attention-deficit/hyperactivity disorder.Öğe The relationship between erythrocyte zinc levels and isotretinoin use in acne vulgaris patients(TAYLOR & FRANCIS LTD, 2015) Bilgic, Ozlem; Altinyazar, Hilmi Cevdet; Sivrikaya, Abdullah; Unlu, AliBackground: Prior studies have demonstrated lower serum zinc levels in acne vulgaris (AV) patients compared with controls. However, no study has investigated the relationship between AV and erythrocyte zinc levels, which is a superior indicator of body zinc levels. Additionally, the potential influence of isotretinoin use on body zinc status remains to be evaluated. In this study, we aimed to determine erythrocyte zinc levels and their relationship with isotretinoin use in AV patients. Methods: The enrolled study participants included 106 (68% female) isotretinoin-treated AV patients, 89 (65% female) untreated AV patients and 100 (59% female) healthy volunteers between 18 and 30 years of age. The acne severity of the AV patients who did not receive treatment was assessed using the classification system of the International Consensus Conference on Acne. Erythrocyte zinc levels were analysed by atomic absorption spectroscopy. Results: No significant differences were observed among the three groups with respect to erythrocyte zinc levels. In addition, erythrocyte zinc levels did not vary according to the severity of AV, nor according to the duration of isotretinoin use. Conclusion: This study suggests that no relationships exist among zinc status, AV and isotretinoin use. However, given the relationship between vitamin A and zinc, and the fact that previous studies have indicated low serum zinc levels in AV patients, prospective studies are required to corroborate our data.Öğe Relationship between sleep quality and facial sebum levels in women with acne vulgaris(MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2016) Bilgic, Ozlem; Bilgic, Ayhan; Altinyazar, Hilmi Cevdet[Abstract not Available]Öğe Serum homocysteine, asymmetric dimethyl arginine (ADMA) and other arginine-NO pathway metabolite levels in patients with psoriasis(SPRINGER, 2015) Bilgic, Ozlem; Altinyazar, Hilmi Cevdet; Baran, Hatice; Unlu, AliHyperhomocysteinemia, a well-known and independent risk factor for cardiovascular disease, has been related in several studies with psoriasis patients. It has been suggested that homocysteine leads to endothelial dysfunction by causing an accumulation of asymmetrical dimethyl arginine (ADMA), a potent endogenous nitric oxide (NO) synthase inhibitor of the l-arginine-NO pathway. However, limited data is available regarding the psoriasis and ADMA relationship. In this study, we aimed to investigate the serum levels of homocysteine, ADMA and other metabolites from the l-arginine-NO pathway in psoriasis patients. Forty-two patients with chronic plaque psoriasis and 48 controls were enrolled in the study. Serum homocysteine, ADMA, l-monomethyl-l-arginine (l-NMMA), symmetric dimethylarginine (SDMA) and l-arginine levels, and l-arginine/ADMA ratios of psoriasis patients and the control group were measured. The severity of psoriasis was assessed by the psoriasis area and severity index (PASI). The mean ADMA and homocysteine values were significantly higher, and citrulline and l-arginine/ADMA values were significantly lower in psoriasis patients compared to control subjects. However, there were no significant differences among the patient and control groups with respect to mean SDMA, l-NMMA and l-arginine values. PASI scores strongly correlated with the ADMA level and moderately correlated with l-arginine/ADMA ratio. This study suggests that the l-arginine-NO pathway metabolites, especially ADMA, may play an important role in the pathogenesis of psoriasis. Additionally, serum ADMA levels of psoriasis patients may be an indicator of the disease severity.Öğe Serum levels of TWEAK in patients with psoriasis vulgaris(ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2016) Bilgic, Ozlem; Sivrikaya, Abdullah; Toker, Aysun; Unlu, Ali; Altinyazar, CevdetTumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) has been implicated in the pathogenesis of a variety of inflammatory disorders and autoimmune diseases. However, studies conducted on the relationship of TWEAK and psoriasis patients are limited. In this study, we aimed to explore the serum levels of TWEAK and investigated whether TWEAK levels are associated with clinical variables and expression of other well-known psoriasis-related cytokines including IL-6, IL-23 and TNF-alpha. Fortyfive patients with chronic plaque psoriasis and 43 controls were enrolled in this study. The severity of psoriasis was assessed by the Psoriasis Area and Severity Index (PASI). Serum levels of cytokines were measured using commercial enzyme-linked immunosorbent assay (ELISA) kits. The mean TWEAK, IL-6, IL-23, and TN-alpha levels were significantly higher in psoriasis patients than in control subjects. However, there were no significant correlations between the psoriasis severity, the illness duration and serum cytokine levels. This study shows that TWEAK may be associated with the pathogenesis of psoriasis, like TNF-alpha, IL-6, and IL-23. (C) 2015 Elsevier Ltd. All rights reserved.Öğe Temperament-Character Profiles in Patients with Alopecia Areata(KURE ILETISIM GRUBU A S, 2013) Annagur, Bilge Burcak; Bilgic, Ozlem; Simsek, Kismet Kaya; Guler, OzkanObjective: Alopecia areata (AA) is a chronic immunological skin disorder characterized by round or oval patches of non-scarring hair loss. Current psychosomatic medicine focuses on the triggering of various diseases by stress and on psychoimmunological changes related to psychosocial stress. There has been little research on the personality traits in alopecia areata. The aim of this study is to examine temperament character profiles and psychopathology of AA patients and to compare the findings with healthy controls. Method: Seventy-three patients who applied to outpatient clinics of dermatology for AA were included. The control group (n=78) was recruited from a non-clinical population. General psychopathology was assessed with the revised version of the Symptom Checklist-90 (SCL-90-R). Personality was assessed using the Temperament and Character Inventory (TCI). Results:The Global Severity Index (GSI) and depression subscale of the SCL-90-R scores were higher in the AA than in the control group (p<0.05). Total scores of novelty seeking (NS), reward dependence (RD), and self-transcendence. (ST) of the patient groups were significantly lower than those of the control groups (p<0.05). When depression and anxiety were considered as covariates, the significant difference which was detected by the t-test still existed between the two groups in terms of NS, RD and ST. Conclusion: It is well known that psychiatric symptoms are common in AA. This study suggests that AA patients have distinctive temperaments such as novelty seeking, reward dependence and self-transcendence dimension compared with healthy controls. AA patients with low NS, RD and ST scores may be prone to depression.Öğe Vemurafenib-induced pityriasis amiantacea: a case report(TAYLOR & FRANCIS LTD, 2016) Bilgic, OzlemVemurafenib, a novel treatment for patients with BRAF-positive metastatic melanoma, is associated with a wide spectrum of cutaneous adverse events both benign and malignant. Vemurafenib-induced pityriasis amiantacea (PA), a scaling reaction of the scalp that may cause temporary or cicatricial alopecia, has not yet been reported in the literature. In the present case, PA was observed two months after the initiation of vemurafenib therapy for metastatic melanoma and managed with symptomatic treatment without the need to cease or modify the vemurafenib dosage.Öğe Vogt-Koyanagi-Harada Disease in an Adolescent Boy(WILEY-BLACKWELL, 2014) Bilgic, Ozlem; Gunduz, Abuzer; Kaya, KismetVogt-Koyanagi-Harada (VKH) disease is a rare multiorgan disorder that affects the melanocytes of the eyes, skin, inner ear, and meninges. It is more common in women and in patients 30 to 50 years of age; it is rarely seen in children. We report a 14-year-old boy who meets the criteria for complete VKH disease.