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    Do you know this syndrome? Werner syndrome
    (SOC BRASILEIRA DERMATOLOGIA, 2017) Bilgic, Ozlem
    Werner syndrome is a rare autosomal recessive disorder, caused by mutations in the WRN gene. Clinical findings include: senile appearance, short stature, grey hair, alopecia, bird-like face, scleroderma-like skin changes, skin ulcers, voice abnormalities, cataracts, osteoporosis, type 2 diabetes mellitus, ischemic heart disease and hypogonadism. The syndrome begins to become apparent in adolescence but it is usually diagnosed in the third or fourth decade of life. Since the patients usually die by the age of 40-50 years related to malignant neoplasms or atherosclerotic complications, they should be closely followed and treated for complications.
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    Possible atomoxetine-induced vitiligo: a case report
    (SPRINGER WIEN, 2015) Bilgic, Ozlem; Bilgic, Ayhan
    Vitiligo is a chronic skin disease characterized by the appearance of white depigmented lesion due to a loss of melanocytes. The etiopathogenesis of vitiligo is not clear, but according to the neural theory of vitiligo, the direct and indirect effects of monoamine neurotransmitters cause melanocyte destruction and various studies have supported this theory. Many drugs have been related to the development of vitiligo, and the melanocytotoxic effects of the some of these drugs are thought to be related due to their effects on the monoaminergic system. Furthermore, a recent article reported the development of a localized loss of pigmentation after the application of a methylphenidate patch in a patient with attention-deficit/hyperactivity disorder (ADHD). Atomoxetine is an inhibitor of norepinephrine reuptake sites and is a drug that has been used for the treatment of ADHD. Here, we present a school-aged child with ADHD who displayed a vitiligo lesion following the initiation of atomoxetine. We further discuss the possible impact of the ADHD drugs on the development of vitiligo.
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    Temperament-Character Profiles in Patients with Alopecia Areata
    (KURE ILETISIM GRUBU A S, 2013) Annagur, Bilge Burcak; Bilgic, Ozlem; Simsek, Kismet Kaya; Guler, Ozkan
    Objective: Alopecia areata (AA) is a chronic immunological skin disorder characterized by round or oval patches of non-scarring hair loss. Current psychosomatic medicine focuses on the triggering of various diseases by stress and on psychoimmunological changes related to psychosocial stress. There has been little research on the personality traits in alopecia areata. The aim of this study is to examine temperament character profiles and psychopathology of AA patients and to compare the findings with healthy controls. Method: Seventy-three patients who applied to outpatient clinics of dermatology for AA were included. The control group (n=78) was recruited from a non-clinical population. General psychopathology was assessed with the revised version of the Symptom Checklist-90 (SCL-90-R). Personality was assessed using the Temperament and Character Inventory (TCI). Results:The Global Severity Index (GSI) and depression subscale of the SCL-90-R scores were higher in the AA than in the control group (p<0.05). Total scores of novelty seeking (NS), reward dependence (RD), and self-transcendence. (ST) of the patient groups were significantly lower than those of the control groups (p<0.05). When depression and anxiety were considered as covariates, the significant difference which was detected by the t-test still existed between the two groups in terms of NS, RD and ST. Conclusion: It is well known that psychiatric symptoms are common in AA. This study suggests that AA patients have distinctive temperaments such as novelty seeking, reward dependence and self-transcendence dimension compared with healthy controls. AA patients with low NS, RD and ST scores may be prone to depression.
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    Vemurafenib-induced pityriasis amiantacea: a case report
    (TAYLOR & FRANCIS LTD, 2016) Bilgic, Ozlem
    Vemurafenib, a novel treatment for patients with BRAF-positive metastatic melanoma, is associated with a wide spectrum of cutaneous adverse events both benign and malignant. Vemurafenib-induced pityriasis amiantacea (PA), a scaling reaction of the scalp that may cause temporary or cicatricial alopecia, has not yet been reported in the literature. In the present case, PA was observed two months after the initiation of vemurafenib therapy for metastatic melanoma and managed with symptomatic treatment without the need to cease or modify the vemurafenib dosage.
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    Vogt-Koyanagi-Harada Disease in an Adolescent Boy
    (WILEY-BLACKWELL, 2014) Bilgic, Ozlem; Gunduz, Abuzer; Kaya, Kismet
    Vogt-Koyanagi-Harada (VKH) disease is a rare multiorgan disorder that affects the melanocytes of the eyes, skin, inner ear, and meninges. It is more common in women and in patients 30 to 50 years of age; it is rarely seen in children. We report a 14-year-old boy who meets the criteria for complete VKH disease.