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Öğe The assessment of liver function in cows with spontaneous ketosis(INDIAN VETERINARY JOURNAL, 2004) Sevinc, M; Basoglu, A; Ok, M; Birdane, FM[Abstract not Available]Öğe Effects of nutritional therapy or N-acetyl-cysteine (NAC) treatment on biochemical markers and liver histology in dogs with CCL4-induced hepatic necrosis(ECOLE NATIONALE VETERINAIRE TOULOUSE, 2005) Sen, I; Turgut, K; Ok, M; Kiran, MM; Guzelbektes, H; Ortatatli, M; Birdane, FMThe purpose of this study is to evaluate the potential beneficial effects of nutritional therapy or N-acetyl Cysteine (NAC) treatment on hepatic necrosis experimentally induced by CCL4 in dogs. Eighteen healthy mixed breed dogs of both sexes were randomly divided into 3 equal groups and received a single oral dose of CCL4 (2.5 ml/kg body weight). Dogs of control group and of experimental group I were fed with maintenance diet (Hills) and with canine prescription k/d diet (Hills) respectively, once a day. Dogs of the experimental goup II were fed with maintenance diet and were treated by NAC (140 mg/kg in the first oral dose followed by 70 mg/kg 6 hours later for 30 days). Serum enzyme (ALT and ALP) activities and bilirubin concentrations (total and direct) were monitored on the 1(st), 5(th), 10(th), 20(th) and 30(th) days. Ultra-sonographies, BSP clearance and liver biopsies for histological evaluation were performed on the 10(th), 20th and 30th days. Marked increases of serum enzyme activities were noticed since the 1(st) day and persisted until the 15th - 20th days in all CCL4-intoxicated dogs. Total and unconjugated bilirubin concentrations also slightly increased in serum of control dogs and dogs of the experimental group I (nutritional therapy) from the 1(st) day to the 15th day, whereas in dogs treated by NAC, significant fluctuations have persisted until the 30(th) day. BSP retention rates were markedly extended from the 1(st) to the 20(th) days in all groups, but the BSP clearance was significantly more depressed in control dogs and in dogs treated by NAC than in those received nutritional therapy (p < 0.05). Morphological changes (hyperechogenicity of the liver parenchyma) and tissue lesions (hydropic degeneration and hepatic necrosis) were evidenced in all dogs. Nevertheless, degenerative changes were less severe (only grades 1 and 2, particularly on the 20(th) and 30(th) days) and were associated with an increase of hepatocyte regeneration in experimental group II. These results showed that the intensity of liver injure could be assessed through BSP retention test and histological analysis and that nutritional therapy, not NAC treatment. partially attenuated CCI4 - hepatotoxicity in dog.Öğe The evaluation of coagulation profiles in calves with suspected septic shock(SPRINGER, 2006) Irmak, K; Sen, I; Col, R; Birdane, FM; Guzelbektes, H; Civelek, T; Yilmaz, AThe purpose of the study reported here was to evaluate the haemostatic function in calves with suspected septic shock and to reflect the occurrence of disseminated intravascular coagulation (DIC). Twenty-six calves suspected of having septic shock (experimental group) and 10 clinically healthy calves (control group) were used. On admission, the experimental group of calves had been ill for an average of 2 days. Therapy was applied to the experimental group of calves. The packed cell volume (PCV), haemoglobin (Hb), white blood cell (WBC), red blood cell (RBC) and platelet (PLT) counts were determined. Blood smears for toxic neutrophil and schistocyte intensity were evaluated. For the coagulation profile, plasma activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen and fibrin/fibrinogen degradation products (FDPs) values were determined. Toxic neutrophils in blood smears were observed in 12 calves of the experimental group. APTT was prolonged in the experimental group compared with the control group (p < 0.05). Fibrinogen concentration was found to be higher in the experimental group than in the control group (p < 0.001). Total leukocyte counts were higher in the experimental group compared with the control group (p < 0.01). Platelet counts in the experimental group were lower than the control group (p < 0.001). However, when the individual values of coagulation profiles of each calf were evaluated, 8 calves had at least three abnormal coagulation profiles (APTT > 72 s, PT > 34.5 s, TT > 33.7 s, FDPs > 5 mu g/ml, PLT <= 150 x 10(3)/mm(3)) and abnormal erythrocyte morphology (schistocytes >= 1). The most common abnormal tests in the coagulation profile were APTT and PT (7 cases), FDPs (6 cases), thrombocytopenia (4 cases), and schistocytes in blood smears (8 cases) in these 8 calves. The results of this study indicate that DIC might be a significant risk factor for mortality in calves with suspected septic shock.Öğe Renal cell carcinoma in a dog: Pathologic and cytologic findings(ECOLE NATIONALE VETERINAIRE TOULOUSE, 2004) Birdane, FM; Hatipoglu, F; Ortatatli, M; Koc, Y; Turgut, KThis study presents a dog with a history of anorexia, vomiting and abdominal distention of one week duration. Abdominal palpation revealed a mass in the right abdominal quadrant. Laboratory abnormalities included slight anaemia, leukocytosis, thrombocytosis, hypoalbuminaemia, hypokalaemia, hypocalcaemia and metabolic acidosis. Urine was reddish in color with 3+ protein and blood reaction, 2+ leukocyte, and 2+ glucose. Erythrocytes and leukocytes casts and innumerous renal and transitional epithelial were present. Ultrasonographic examination revealed a solitary mass taking the place of right kidney. Urine sediment cytology revealed large clusters of markedly pleomorphic cells. Mitotic figures in some cells were observed. A large tumour mass was found at laparotomy. The right kidney was replaced by this massive ball shaped tumour. Unilateral nephrectomy was performed and renal cell carcinoma was diagnosed by microscopic examination.
