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Öğe 24-h Efficacy of Glaucoma Treatment Options(SPRINGER, 2016) Konstas, Anastasios G. P.; Quaranta, Luciano; Bozkurt, Banu; Katsanos, Andreas; Garcia-Feijoo, Julian; Rossetti, Luca; Shaarawy, TarekCurrent management of glaucoma entails the medical, laser, or surgical reduction of intraocular pressure (IOP) to a predetermined level of target IOP, which is commensurate with either stability or delayed progression of visual loss. In the published literature, the hypothesis is often made that IOP control implies a single IOP measurement over time. Although the follow-up of glaucoma patients with single IOP measurements is quick and convenient, such measurements often do not adequately reflect the untreated IOP characteristics, or indeed the quality of treated IOP control during the 24-h cycle. Since glaucoma is a 24-h disease and the damaging effect of elevated IOP is continuous, it is logical that we should aim to understand the efficacy of all treatment options throughout the 24-h period. This article first reviews the concept and value of diurnal and 24-h IOP monitoring. It then critically evaluates selected available evidence on the 24-h efficacy of medical, laser and surgical therapy options. During the past decade several controlled trials have significantly enhanced our understanding on the 24-h efficacy of all glaucoma therapy options. Nevertheless, more long-term evidence is needed to better evaluate the 24-h efficacy of glaucoma therapy and the precise impact of IOP characteristics on glaucomatous progression and visual prognosis.Öğe 24-h Efficacy of Glaucoma Treatment Options (vol 33, pg 481, 2016)(SPRINGER, 2016) Konstas, Anastasios G. P.; Quaranta, Luciano; Bozkurt, Banu; Katsanos, Andreas; Garcia-Feijoo, Julian; Rossetti, Luca; Shaarawy, Tarek[Abstract not Available]Öğe Are preservatives necessary to improve efficacy of some glaucoma drops?(BMJ PUBLISHING GROUP, 2013) Irkec, Murat; Bozkurt, Banu; Mocan, Mehmet Cem[Abstract not Available]Öğe Association of tumour necrosis factor-alpha -308 G/A polymorphism with primary open-angle glaucoma(WILEY-BLACKWELL, 2012) Bozkurt, Banu; Mesci, Lutfiye; Irkec, Murat; Ozdag, Burcin B.; Sanal, Ozden; Arslan, Umut; Ersoy, FugenBackground: Tumour necrosis factor-alpha (TNF-a) is an important proinflammatory cytokine driving axonal degeneration and retinal ganglion cell apoptosis in glaucoma. The aim of the study was to evaluate the association of TNF-a -308 G/A and -238 G/A polymorphisms with primary open-angle glaucoma (POAG). Design: A prospective, casecontrol study, university hospital setting. Participants: Eighty-six POAG patients and 193 healthy unrelated controls. Methods: TNF-a polymorphisms were screened by using direct gene sequencing. Main Outcome Measures: Frequency of TNF-a -308 G/A and TNF-a -238 G/A promoter polymorphisms in glaucoma and healthy subjects. Results: The frequencies of TNF-a -308 GA genotype and A allele were higher in patients with POAG (22.1% and 12.2%, respectively) in comparison with the control group (10.9% and 6%, respectively) (P = 0.046 and 0.02, respectively), with odds ratios of 2.45 (P = 0.01, 95% CI = 1.234.87) and 2.19 (P = 0.013, 95% CI = 1.184.08), respectively. Genotype distribution of the TNF-a -238 variants did not yield a statistically significant difference between the two groups (P = 0.87). Conclusion: TNF-a -308 G/A polymorphism seems to be associated with POAG in Turkish population. However, population-based studies with large number of subjects and long-term follow-up are needed to verify the association of TNF-a -308 G/A polymorphism with glaucoma susceptibility.Öğe Asymmetry in optic disc morphometry as measured by confocal scanning laser ophthalmoscopy in subjects with hyperopic anisometropia(SLACK INC, 2008) Bozkurt, Banu; Irkec, Murat; Arslan, UmutPurpose: To determine whether there is an asymmetry in optic nerve head morphometry in subjects with hyperopic anisometropia. Methods: Seventeen men and 20 women with a mean age of 31.43 +/- 2.73 (standard error of mean) years underwent a complete eye examination and optic nerve head topography with the Heidelberg Retina Tomograph II (Heidelberg Engineering, GmBH, Heidelberg, Germany). Differences in optic nerve head parameters between anisometropic eyes and fellow eyes were evaluated using the paired-sample t test or Wilcoxon signed rank test and the correlations between refraction, visual acuity, and disc parameters were evaluated with Spearman's correlation coefficient. Results: The median refractive errors of hyperopic anisometropic and fellow eyes were +4 D (range: +2.0 to +7.50 D) and 0 D (range: 0 to +4 D), respectively. The mean best-corrected visual acuity of the amblyopic eyes was 0.43 +/- 0.25. The mean disc area of the anisometropic eyes (1.69 +/- 0.35 mm(2)) was significantly smaller than the fellow eyes (2.01 +/- 0.42 mm(2)) (P < .001). The differences between eyes in mean cup area, rim area, rim volume, and cup shape were statistically significant (P < .05). In aniosmetropic eyes, refractive error (r = -0.406; P = .013) and visual acuity (r = 0.347; P = .035) showed significant correlations with rim area. Conclusion: Hyperopic anisometropia is associated with a remarkable interocular difference in optic disc size and other topographic parameters.Öğe Atypical Herpetic Corneal Endotheliitis: A Case Report(2016) Karalezli, Aylin; Kucukoduk, Ali; Bozkurt, BanuKorneal endotelit, sıklıkla viral orijinli olan ve primer olarak kornea endotelinin iflamasyonunun gözlendiği bir hastalıktır. Bu olgu sunumunda ön kamara reaksiyonunun gözlenmediği sadece tek taraflı yaygın korneal ödem ile giden atipik herpetik korneal endotelitli bir olguyu sunuyoruz.Öğe Atypical Herpetic Corneal Endothelitis(DERMAN MEDICAL PUBL, 2016) Karalezli, Aylin; Kucukoduk, Ali; Bozkurt, BanuCorneal endotheliitis; frequently caused by viruses, is a disorder in which corneal endothelium is the primary site of the inflammation. We discuss a case of atypical herpetic endotheliitis presented with unilateral diffuse corneal edema with no signs of anterior chamber reaction.Öğe Bietti kristalin retinopatisinde optik koherens tomografi bulguları(2011) Öztürk, Turgut Banu; Bozkurt, Banu; Kamış, Ümit; Okka, MehmetBietti’nin kristalin retinopatisi tanısı alan iki olgumuzun optik koherens tomografi (OKT ) bulguları incelendi. Kliniğimize görme azalması yakınması ile başvuran olguların fundus muayenesinde arka kutupta yaygın kristalin depozitleri ve retina pigment epiteli atrofisi izlendi. OKT ’de sensöryel retina tabakasında yüksek yansıtıcılık gösteren alanlar ve retina pigment epiteli-koryokapillaris kompleksinde kalınlaşma ve yansıma artışı gözlendi. Bu olgular OKT ’nin Bietti kristalin retinopatisinde kristal birikintilerinin ve retina pigment epitel atrofisinin izlenmesinde yardımcı bir tetkik olduğunu göstermektedir.Öğe Bilateral acute depigmentation of the iris (BADI): first reported case in Brazil(CONSEL BRASIL OFTALMOLOGIA, 2014) Gonul, Saban; Bozkurt, Banu[Abstract not Available]Öğe Bilateral acute iris transillumination (BAIT) initially misdiagnosed as acute iridocyclitis(CONSEL BRASIL OFTALMOLOGIA, 2015) Gonul, Saban; Bozkurt, BanuBilateral acute iris transillumination (BAIT) is a relatively new clinical entity characterized by bilateral acute loss of iris pigment epithelium, iris transillumination, pigment dispersion in the anterior chamber, and sphincter paralysis. We report the case of a 30-year-old male who was initially diagnosed with acute iridocyclitis in a different clinic and treated with topical and systemic corticosteroids. He was referred to our clinic to seek another opinion because his symptoms did not improve. An ocular examination revealed bilateral pigment dispersion into the anterior chamber, diffuse iris transillumination, pigment dusting on the anterior lens capsule, atonic and distorted pupils, and increased intraocular pressure, suggesting a diagnosis of BAIT rather than iridocyclitis. Clinicians should be aware of the differential diagnosis of syndromes associated with pigment dispersion from iridocyclitis to avoid aggressive anti-inflammatory therapy and detailed investigation for uveitis.Öğe Bilateral acute iris transillumination following a fumigation therapy: a village-based traditional method for the treatment of ophthalmomyiasis(TAYLOR & FRANCIS LTD, 2015) Gonul, Saban; Bozkurt, Banu; Okudan, Suleyman; Tugal-Tutkun, IlknurBilateral acute iris transillumination (BAIT) is a relatively new clinical entity characterized by bilateral acute loss of iris pigment epithelium, iris transillumination, pigment dispersion in the anterior chamber and atonic pupilla. We report herein a 50-year-old female who presented with bilateral ocular pain, severe photophobia and red eyes. One month ago, a fly hit her eye, and she instantly complained of a discomfort and sensation of a foreign body in both eyes. She used a fumigation therapy, a traditional method for the treatment of ophthalmomyiasis. During follow-up examinations, intraocular pressures increased over 40 mmHg bilaterally despite maximal medical therapy, which necessitated trabeculectomy surgery with mitomycin. This is a typical BAIT case with no antecedent fluoroquinolone use or viral disease, but a fumigation therapy. There might be a possible relationship between BAIT and traditional fumigation therapy or this association might be coincidental, both of which need further evaluation.Öğe Bilgisayar Kullanıcılarında Görülen Oküler Yüzey Değişikliklerinin Değerlendirilmesi(Turkish Ophthalmology Society, 2012) Büyükbaş, Zeynep; Gündüz, Mehmet Kemal; Bozkurt, Banu; Zengin, NazmiPurpose: To evaluate the ocular surface changes related to computer use. Ma te ri al and Met hod: 40 volunteered subjects working in secretarial duties who spend at least 6 hours a day using computers in Selcuk University Meram Faculty of Medicine (Group 1) and 50 healthy control subjects who spend less than 6 hours a day using computers (Group 2) were evaluated. Following routine ophthalmological examination, tear break up time (BUT), Schirmer’s test (with topical anesthesia and without topical anesthesia) and OSDI (Ocular surface disease index) were recorded for all subjects. All computer users were visited at their working environment to evaluate the computers’ monitor properties, monitor positions, and the existence of air conditioner and to count the eye blinks per minute during computer use. Statistical analyses were made by using SPSS software package. Wilcoxon signed-rank test was used in the comparison of right and left eyes, whereas Mann-Whitney U test was used in the comparison of Group 1 with Group 2; p<0.05 was considered statistically significant. Re sults: There were 18 males (45%) and 22 females (55%) with a mean age of 27.73±4.8 years in Group 1. There were 27 males (54%) and 23 females (46%) with an average age of 25.96±4.2 years in Group 2. Time spent on computer use was 9.00±1.8 hours/day in Group 1 and 1.92±1.1 hours/day in Group 2 (p<0.001). Eye blinks per minute, BUT, and Schirmer’s test with/without anesthesia were significantly lower in Group 1 compared to Group 2 (p<0.001), whereas OSDI scores were significantly higher in Group 1(p<0.001). There were no differences in tear parameters between subjects with and without air conditioning in Group 1 (p>0.05). BUT, Schirmer’s test with anesthesia and OSDI scores showed no differences according to monitor position and properties (p>0.05). Dis cus si on: Long-term computer use leads to a decrease in eye blink rate, deterioration in tear function tests and dry eye symptoms.Öğe Bilgisayar kullanıcılarında görülen oküler yüzey değişikliklerinin değerlendirilmesi(2012) Büyükbaş, Zeynep; Gündüz, Mehmet Kemal; Bozkurt, Banu; Zengin, NazmiAmaç: Bu çalışmada bilgisayar kullanımına bağlı olarak ortaya çıkabilecek oküler yüzey değişikliklerinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Selçuk Üniversitesi Meram Tıp Fakültesinde sekreter olarak çalışan ve günlük bilgisayar kullanım süreleri en az 6 saat olan 40 gönüllü birey (Grup 1) ve bilgisayar kullanım süresi 6 saatin altında olan 50 sağlıklı birey (Grup 2) incelendi. Katılımcıların rutin göz muayenelerini takiben gözyaşı kırılma zamanı (GKZ) ölçüldü, anestezili ve anestezisiz Schirmer testleri yapıldı ve OSDI (Oküler yüzey hastalık indeksi) anketi uygulandı. Grup 1’deki katılımcılar çalışma ortamlarında ziyaret edilerek bilgisayarların monitör özellikleri, monitör pozisyonları, ortamda klima bulunup bulunmadığı ve bilgisayar kullanımı sırasında dakikadaki göz kırpma sayıları belirlendi. İstatistiksel analizler SPSS paket program kullanılarak yapıldı. Sağ ve sol gözlerin karşılaştırılmasında Wilcoxon-Signed testi, Grup 1 ve 2’nin karşılaştırılmasında Mann-Whitney U testi kullanıldı ve p0,05 istatistiksel olarak anlamlı kabul edildi. Sonuçlar: Grup 1’deki bireylerin %45’i erkek, %55’i kadındı ve yaş ortalaması 27,734,8 yıldı. Grup 2’dekilerin %54’ü erkek, %46’sı kadındı ve yaş ortalaması 25,964,2 yıldı. Günlük bilgisayar kullanım süreleri birinci grupta 9,001,8 saat, ikinci grupta 1,921,1 saat olarak tespit edildi (p0,001). Grup 1’de göz kırpma sayısı, GKZ, anestezisiz ve anestezili Schirmer testleri grup 2’den istatistiksel olarak daha düşük bulunurken (p0,001), OSDI skorlaması istatistiksel olarak anlamlı derecede yüksek bulundu (p0,001). Grup 1’de çalışma ortamında klima bulunan hastaların gözyaşı parametreleri ve OSDI skorları klima bulunmayan bireylerden farklılık göstermemekteydi (p0,05). Grup 1’de GKZ, anestezili Schirmer ve OSDI skorları ekran pozisyonuna ve tipine göre farklılık göstermemekteydi (p0,05). Tarışma: Bilgisayarın uzun süreli kullanımı göz kırpma sayısında azalmaya, gözyaşı fonksiyon testlerinde bozulmaya ve kuru göz semptomlarına neden olmaktadır. (Turk J Ophthalmol 2012; 42: 190-6)Öğe Bir Olgu Sebebiyle Tek Taraflı Optik Atrofi Etiyolojisinde Hipofiz Adenomlarının Yeri: Olgu Sunumu(Selçuk Üniversitesi, 2017 Haziran) Oflaz, Ayşe Bozkurt; Gedik, Şansal; Bozkurt, Banu; Öztürk, Banu Turgut; Okudan, SüleymanHipofiz adenomları gerçek kapsül ihtiva etmeyen adenohipofizyel hücrelerden oluşan metastaz yapmayan neoplazilerdir. Hipofiz adenomları intrakraniyel kitlelerin %10-15'ini oluştururlar. En sık 3-6. dekadlarda görülürken, çocuklarda nadirdir. Hipofiz adenomları boyut olarak 1 cm’den küçük ise mikroadenom, 1 cm’den büyük ise makroadenom olarak sınıflandırılır. Mikroadenomların aksine makroadenomlar görsel semptomlara, görme alanı defektine ve hipofiz yetmezliğine sebep olabilir. Hipofiz makroadenomları, benign tümöral olgular olarak kabul edilseler de nörovasküler bası ve hipopituitarizm yoluyla klinik tabloyu kötüleştirebilirler. Optik sinire bası yapan tümor patofizyolojik olarak desendan optik atrofiye yol açabilir. Optik diskin atrofik görünümü hastanın görme keskinliğini ve görme kalitesini önemli derecede düşüren, bir takım klinik olaylar zincirinin son basamağı olarak karşımıza çıkan bir tablodur. Bu nedenle takip ve tedavide fikir sahibi olabilmek için optik atrofi ile karşılaşıldığında ayırıcı tanı yapmak, hasta için önem arz etmektedir. Biz bu olguda tek taraflı optik disk atrofisinden yola çıkılarak yapılan görüntüleme sayesinde tanı konulan makroadenom hastasını sunmayı amaçladık.Öğe Brinzolamide/timolol fixed combination: a new ocular suspension for the treatment of open-angle glaucoma and ocular hypertension(TAYLOR & FRANCIS LTD, 2009) Hollo, Gabor; Bozkurt, Banu; Irkec, MuratFor the treatment of open-angle glaucoma, the most frequent cause of irreversible visual loss, fixed combinations of different topical intraocular pressure (IOP) lowering molecules have gained an important role in recent years. The use of fixed combinations reduces the number of daily instillations, which promotes adherence to the prescribed medication and diminishes the exposition of the ocular surface to preservatives. The fixed combination of brinzolamide and timolol was recently approved by the European Medicines Agency (EMEA) and is now available in several countries in Europe. It contains two molecules widely used to treat glaucoma: timolol 0.5% (5 mg/ml) and brinzolamide 1% (10 mg/ml) in ophthalmic suspension formulation. This fixed combination is approved for twice-daily instillation to reduce elevated IOP in open-angle glaucoma and ocular hypertension. The brinzolamide/timolol fixed combination provides an approximately 30-33% IOP reduction from the untreated baseline IOP of 25-27 mmHg; thus, it is more potent than either of its ingredients alone. It is similarly effective but better tolerated than the dorzolamide/timolol fixed combination, which consists of molecules from the same pharmacological classes. The brinzolamide/timolol fixed combination can be used by itself as a separate therapy, but owing to the additivity of its ingredients to IOP-lowering drugs belonging to other classes, it may also be administered adjunctive to other IOP-reducing molecules, most importantly topical prostaglandin analogues. The ocular and systemic tolerance of the brinzolamide/timolol fixed combination was reported favorable in Phase III studies, but no long-term clinical experience with this preparation is available at present.Öğe Chandler syndrome manifesting as ectropion uvea following laser in situ keratomileusis(ELSEVIER SCIENCE INC, 2008) Mocan, Mehmet C.; Bozkurt, Banu; Orhan, Mehmet; Irkec, MuratWe report the case of a 30-year-old woman with recent onset of unilateral iris distortion and glaucoma that was noticed following uneventful laser in situ keratomileusis (LASIK). The corneal endothelium in the right eye appeared normal with the slitlamp microscope, and LASIK-related anterior segment ischemia was initially considered in the differential diagnosis. However, in vivo confocal microscopy revealed abnormal endothelial cells, confirming the diagnosis of iridocorneal endothelial syndrome. In patients having refractive corneal procedures, in vivo confocal microscopy is recommended to diagnose preexisting corneal abnormalities that might otherwise remain undetected.Öğe Characteristics of the Anterior Segment Biometry and Corneal Endothelium in Eyes with Pseudoexfoliation Syndrome and Senile Cataract(TURKISH OPHTHALMOLOGICAL SOC, 2015) Bozkurt, Banu; Guzel, Huseyin; Kamis, Umit; Gedik, Sansal; Okudan, SuleymanObjectives: To evaluate the anterior segment biometric features and corneal endothelial changes in eyes with pseudoexfoliation (PEX) syndrome and senile cataract. Materials and Methods: The central corneal thickness, anterior chamber depth (ACD), pupil diameter, lens thickness, endothelial cell density (ECD), and percentages of polymegathism and pleomorphism of 52 subjects with PEX and cataract were compared with 51 age-and gender-matched control subjects with cataract using optical low-coherence reflectometry (OLCR, Lenstar LS 900; Haag Streit AG, Switzerland) and in-vivo confocal microscopy (Confo Scan 4, Nidek Co. Ltd, Osaka, Japan). Nineteen subjects with PEX syndrome had glaucoma and were using anti -glaucoma medications. Only one eye of the subjects was used in statistical analysis and a p value less than 0.05 was considered statistically significant. Results: None of the OLCR parameters reached statistically significant differences among the 3 groups (ANOVA p>0.05). The percentage of eyes with ACD <2.5 mm was 13.7% in the control group, 24.2% in PEX eyes without glaucoma and 21.1% in PEX eyes with glaucoma, with no statistically significant differences (p=0.45). There was a significant difference in mean ECD among the 3 groups (ANOVA p=0.02), whereas no differences could be found in respect to polymegathism and pleomorphism (p>0.05). Mean ECD was significantly lower in the PEX glaucoma group (2,199.5 +/- 176.8 cells/mm(2)) than the control group (2,363 +/- 229.3 cells/mm(2)) (p = 0.02), whereas no difference was found in mean ECD of PEX eyes without glaucoma and the control group (p=0.42). ECD was less than 2,000 cells/mm(2) in 15.8% of PEX subjects with glaucoma, 9.8% of control subjects and 6.1% of PEX eyes without glaucoma, with no statistically significant difference (p=0.52). Conclusion: As eyes with both PEX glaucoma and cataract seem to be associated with decreased endothelial cell number, specular or confocal microscopy screening should be done for the patients scheduled for intraocular surgery.Öğe Comparison of Intravitreal Bevacizumab and Ranibizumab Treatment for Diabetic Macular Edema(MARY ANN LIEBERT, INC, 2011) Ozturk, Banu Turgut; Kerimoglu, Hurkan; Bozkurt, Banu; Okudan, SuleymanAim: The aim of this study was to compare the effects of bevacizumab and ranibizumab on visual function and macular thickness in patients with diabetic macular edema (DME). Methods: The data of diabetic patients who had been treated with bevacizumab for DME were reviewed. Those patients who received 1 injection of intravitreal bevacizumab and ranibizumab with at least 6-month interval were considered for enrollment. The best-corrected visual acuity (BCVA) assesment with Early Treatment Diabetic Retinopathy Study (ETDRS) chart and central subfield macular thickness (CSMT) measurement using optical coherence tomography-3 before and after the injections were recorded as outcome measures. Results: The study included 29 eyes of 29 patients with a mean age of 56.18 +/- 3.07 years. The median BCVA was 59 ETDRS letters and the median CSMT was 411 mu m preceeding the bevacizumab injection. At the 4th-6th week control after the injection, median BCVA increased to 61.50 ETDRS letters and the median CSMT decreased to 373 mu m. This change in BCVA and CSMT was found to be statistically significant (P = 0.029 and P = 0.011, respectively). The mean interval between bevacizumab and ranibizumab treatment was 9.54 +/- 2.64 months. Ranibizumab treatment increased the median BCVA from 53 to 66 ETDRS letters and decreased the median CSMT from 428 mu m to a level of 279 mu m, which were statistically significant (P < 0.001 and P < 0.001, respectively). The median change in BCVA was 4.5 ETDRS letters in the bevacizumab group and 6 ETDRS letters in the ranibizumab group (P = 0.58), whereas the median changes in CSMT were 41 and 100 mu m after bevacizumab and ranibizumab injections, respectively (P = 0.005). Conclusions: Bevacizumab and ranibizumab are both effective antivascular endothelial growth factor drugs preferred in the treatment of DME. Our comparison of both therapies on the same patients suggested that the effect on BCVA was not statistically different, but ranibizumab provided more decrease in CSMT.Öğe Comparison of the efficacy of prednisolone, montelukast, and omalizumab in an experimental allergic rhinitis model(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2014) Bozkurt, Mete Kaan; Tülek, Baykal; Bozkurt, Banu; Akyürek, Nalan; Öz, Mehmet; Kıyıcı, AyselAim: To compare the efficacy of prednisolone, montelukast, and omalizumab in reducing allergic symptoms and inflammation at tissue level in an experimental allergic rhinitis model. Materials and methods: Forty Sprague Dawley rats were randomized into 5 groups as naive (NS/NC), sensitized/challenged (S/C) by subcutaneous ovalbumin antigen injection, and montelukast-, prednisolone-, and omalizumab- treated groups. A nasal allergen challenge was performed every day from day 20 to day 26. The number of sneezes and nasal/eye rubbing movements, IL-4 and CysLT levels in serum, nasal and bronchoalveolar lavage fluids determined by ELISA, and histopathological findings of nasal mucosa, sinus, and lung tissues were compared. Results: All of the treatments significantly controlled the allergic symptoms of sneezing and nasal/eye rubbing (P < 0.05). IL-4 and CysLT levels on days 20 and 26 were significantly higher in the S/C group compared to the NS/NC group (P < 0.05). Montelukast significantly decreased serum and nasal IL-4 and CysLT levels (P < 0.05), prednisolone decreased nasal lavage IL-4 and CysLT levels (P < 0.05), and omalizumab lowered nasal lavage CysLT levels (P < 0.05). Conclusion: Prednisolone, montelukast, and omalizumab were found to be effective in controlling the allergic symptoms of allergic rhinitis and upper/lower airway inflammation in an experimental allergic rhinitis model.Öğe Comparison of visual field test results obtained through Humphrey matrix frequency doubling technology perimetry versus standard automated perimetry in healthy children(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2013) Kocabeyoglu, Sibel; Uzun, Salih; Mocan, Mehmet Cem; Bozkurt, Banu; Irkec, Murat; Orhan, MehmetAims: The aim of this study was to compare the visual field test results in healthy children obtained via the Humphrey matrix 24-2 threshold program and standard automated perimetry (SAP) using the Swedish interactive threshold algorithm (SITA) -Standard 24-2 test. Materials and Methods: This prospective study included 55 healthy children without ocular or systemic disorders who underwent both SAP and frequency doubling technology (FDT) perimetry visual field testing. Visual field test reliability indices, test duration, global indices (mean deviation [MD], and pattern standard deviation [PSD]) were compared between the 2 tests using the Wilcoxon signed-rank test and paired t-test. The performance of the Humphrey field analyzer (HFA) 24-2 SITA-standard and frequency-doubling technology Matrix 24-2 tests between genders were compared with Mann-Whitney U-test. Results: Fifty-five healthy children with a mean age of 12.2 +/- 1.9 years (range from 8 years to 16 years) were included in this prospective study. The test durations of SAP and FDT were similar (5.2 +/- 0.5 and 5.1 +/- 0.2 min, respectively, P = 0.651). MD and the PSD values obtained via FDT Matrix were significantly higher than those obtained via SAP (P < 0.001), and fixation losses and false negative errors were significantly less with SAP (P < 0.05). A weak positive correlation between the two tests in terms of MD (r = 0.352, P = 0.008) and PSD (r = 0.329, P = 0.014) was observed. Conclusion: Children were able to complete both the visual test algorithms successfully within 6 min. However, SAP testing appears to be associated with less depression of the visual field indices of healthy children. FDT Matrix and SAP should not be used interchangeably in the follow-up of children.
