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Öğe Attention deficit hyperactivity disorder symptoms in children with vocal fold nodules(ELSEVIER IRELAND LTD, 2016) Erdur, Omer; Herguner, Arzu; Ozturk, Kayhan; Kibar, Ertugrul; Elsurer, Cagdas; Bozkurt, Mete Kaan; Herguner, SabriObjectives: The aim of this case-control study was to investigate the symptoms of attention-deficit/hyperactivity disorder (ADHD) in children with vocal fold nodules (VNs). Methods: Study group (SG) included children between 4 and 12 years. As a control group (CG), children between 4 and 12 years without VNs were included in the study. Parents of the participants completed the Conners' Parent Rating Scale-Revised: Short Form (CPRS-RS) which was used to analyze the symptoms of ADHD. Results: Forty-five children (30 boys and 15 girls) with VNs and 45 controls (30 boys and 15 girls) were enrolled in the study. Multivariate analysis of variance revealed that the CPRS-RS Hyperactivity and Oppositional Subscales were significantly higher in the SG than the CG (p < .05), after controlling the effects of age and gender. Conclusions: Our findings suggest associations between VNs and hyperactivity and oppositional behaviors in children. Clinicians should be aware of ADHD symptoms in children with VNs. (C) 2016 Elsevier Ireland Ltd. All rights reserved.Öğe Aurikula psödokisti: Olgu sunumu(2011) Bozkurt, Mete Kaan; Saydam, Levent; Özçelik, Tuncay; Keleş, BaharAurikula psödokisti sıklıkla genç erkeklerde görülen, aurikula üst bölümünde yerleşik asemptomatik kistik bir şişliktir. Tedavide birçok farklı metodlar kullanılmaktadır. Bu çalışmada lezyonun cerrahi eksizyon ve sahaya düğme dikilerek sağlanan kompresyon kullanılarak tedavi edildiği ve 2 yıllık izlem süresinde nüks saptanmayan bir aurikula psödokisti olgusu sunulmaktadır. Kullanılan cerrahi yöntem iyi kozmetik sonuç vermesi ve baskılı kulak pansumanı gerektirmemesi nedeniyle hasta memnuniyetini arttırmaktadır.Öğe Ciddi burun tıkanıklığına neden olan dev konka bülloza(2016) Erdur, Ömer; Elsürer, Çağdaş; Kibar, Ertuğrul; Bozkurt, Mete KaanSinonazal bölgenin en sık görülen anatomik varyasyonu olan konka bülloza, orta konkanın pnömatizasyonu olarak tanımlanır. Konka bülloza genellikle asemptomatik olsa da boyutuna bağlı olarak nazal septum ve osteomeatal bölge ile ilişkisine göre semptomatik hale gelebilir. En sık karşılaşılan semptomlar burun tıkanıklığı, baş ve yüz bölgesinde ağrı, koku problemleri, sinüzit, postnazal akıntı ve hipozmidir. Tanı; anterior rinoskopi, endoskopik muayene ve paranazal sinüs tomografisiyle konulur. Tedavide yeterli burun açıklığı sağlamak amacıyla endoskopik yöntemle orta konkanın parsiyel rezeksiyonu yapılır. Bu yazıda kronik baş ağrısı, burun tıkanıklığı ve koku alma bozukluğuna neden olan tek taraflı dev konka büllozası olan 34 yaşında bir kadın hasta literatür eşliğinde sunuldu.Öğe Comparison of the efficacy of prednisolone, montelukast, and omalizumab in an experimental allergic rhinitis model(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2014) Bozkurt, Mete Kaan; Tülek, Baykal; Bozkurt, Banu; Akyürek, Nalan; Öz, Mehmet; Kıyıcı, AyselAim: To compare the efficacy of prednisolone, montelukast, and omalizumab in reducing allergic symptoms and inflammation at tissue level in an experimental allergic rhinitis model. Materials and methods: Forty Sprague Dawley rats were randomized into 5 groups as naive (NS/NC), sensitized/challenged (S/C) by subcutaneous ovalbumin antigen injection, and montelukast-, prednisolone-, and omalizumab- treated groups. A nasal allergen challenge was performed every day from day 20 to day 26. The number of sneezes and nasal/eye rubbing movements, IL-4 and CysLT levels in serum, nasal and bronchoalveolar lavage fluids determined by ELISA, and histopathological findings of nasal mucosa, sinus, and lung tissues were compared. Results: All of the treatments significantly controlled the allergic symptoms of sneezing and nasal/eye rubbing (P < 0.05). IL-4 and CysLT levels on days 20 and 26 were significantly higher in the S/C group compared to the NS/NC group (P < 0.05). Montelukast significantly decreased serum and nasal IL-4 and CysLT levels (P < 0.05), prednisolone decreased nasal lavage IL-4 and CysLT levels (P < 0.05), and omalizumab lowered nasal lavage CysLT levels (P < 0.05). Conclusion: Prednisolone, montelukast, and omalizumab were found to be effective in controlling the allergic symptoms of allergic rhinitis and upper/lower airway inflammation in an experimental allergic rhinitis model.Öğe Gender differences in polysomnographic findings in Turkish patients with obstructive sleep apnea syndrome(SPRINGER, 2008) Bozkurt, Mete Kaan; Oy, Ayfer; Aydin, Dilek; Bilen, Serap Hizel; Erturk, I. Ozcan; Saydam, Levent; Ozgen, FuatIn this study, we evaluated the gender differences in body mass index (BMI), age and their effects on apnea-hypopnea index during total sleep time (AHI(TST)) in the Turkish population who were diagnosed with obstructive sleep apnea syndrome (OSAS) and compared them with data from the literature. A computerized database of 244 Turkish patients (194 males, 50 females) who had undergone overnight polysomnography (PSG) and diagnosed with OSAS at Bayndr Hospital sleep laboratory between October 2004 and January 2007 was reviewed. The male:female ratio of the patients was 3.88:1. Male patients were significantly younger compared to females (48.87 +/- 10.82 vs 52.94 +/- 12.14 years, respectively, P = 0.003). The BMI and AHI(TST) were similar in male and female patients (BMI = 29.52 +/- 4.63 vs 31.17 +/- 6.08 kg/m(2), respectively, P = 0.083) (AHI(TST) = 27.45 +/- 22.97 vs 24.77 +/- 23.83, respectively, P = 0.149). For the male and female groups, AHI(TST) increased as BMI increased (P = 0.03, 0.04). The median values of AHI(TST) in male group, for the normal, overweight and obese + pathological obese groups were 12.45, 20.20 and 23.50, respectively, whereas the median values of AHI(TST) in female group were 11.10, 10.95 and 26.20, respectively. In the normal and obese + pathological obese groups, there was no statistically significant difference according to gender, whereas in the overweight group, male patients had significantly higher AHI(TST) (P = 0.02). There was no statistically significant difference between the male and female patients regarding the severity of OSAS (P = 0.358). However, there was a male tendency to moderate and severe OSAS in the normal and overweight BMI groups. In Turkish patients with OSAS, there was no gender difference in BMI and AHI(TST) and female patients were significantly older than the males. The OSAS was diagnosed in men nearly four times more often than in women.Öğe Maksiller sinüste izole aspergillus enfeksiyonu: Olgu sunumu(2008) Bozkurt, Mete Kaan; Özçelik, Tuncay; Saydam, Levent; Kutluay, LaleMaksiller sinüste aspergillus enfeksiyonları immün yetmezliği olmayan hastalarda nadir görülür. Aspergillusa bağlı paranazal sinüs enfeksiyonlarında Aspergillus fumigatus en sık görülen alttürdür. Kırk bir yaşında kadın hasta yüz ağrısı yakınmasıyla başvurdu. Hastaya yaklaşık beş yıl önce sağ üst molar dişlere kanal tedavisi yapıldığı öğrenildi. Paranazal sinüs tomografisinde, maksiller sinüste radyoopak görünümlü ve yabancı cisim izlenimi veren fungal sinüzit saptandı. Hastaya endoskopik sinüs cerrahisi yapılarak maksiller sinüs temizlendi, çıkartılan materyalin patolojik inceleme sonucu aspergillus enfeksiyonu ile uyumlu bulundu.Öğe Oculomotor Palsy as the Initial Finding in Neurofibromatosis Type 2(Taylor & Francis Inc, 2010) Bozkurt, Banu; Bozkurt, Mete Kaan; Paksoy, Yahya; Kerimoğlu, HurkanA 15-year-old boy with oculomotor palsy in the left eye as the initial finding of neurofibromatosis type 2 (NF2) was presented. The eye motility examination revealed restriction in adduction, elevation and depression of the left eye and mild ptosis of the left eye. Cranial magnetic resonance imaging (MRI) showed a 3 cm sized mass in the cerebellar vermis that showed features of a schwannoma; bilateral lesions in the acoustic canals and bilateral optic nerve buckling: these findings were consistent with a diagnosis of NF2. Further thin-section MRI revealed a mass in the left cavernous sinus segment of the oculomotor nerve and a thickening of the right oculomotor nerve.Öğe Rekürren nazal septal piyojenik granülomun endoskopik eksizyonu(2016) Elsürer, Çağdaş; Erdur, Ömer; Dağıstan, Hakan; Bozkurt, Mete Kaan; Kibar, Ertuğrul; Karabağlı, PınarNazal kavitenin lobüler kapiller hemanjiomları (Piyojenik granülom) benign bir tümör olup etyolojisi tam olarak bilinmemektedir. En çok üzerinde durulan nedenler nazal travma ve hormonal faktörlerdir. Genellikle bir pedinkül ile anterior septum mukozasından kaynaklanırlar. Tek taraflı burun tıkanıklığı ve burun kanaması en önde gelen semptomlardır. Hızlı büyümeleri ve ülseratif görünümlerinden dolayı bazen nazal maligniteler ile karıştırılabilmektedir. Bu yazıda 46 yaşında bir kadın hastada daha önceki tedavilerinden sonra iki kez nüks eden piyojenik granülom olgusunun endoskopik olarak tüm sınırları görülerek tutunduğu mukoza ve perikondrium ile birlikte çıkarılması sunuldu. Nazal piyojenik granülom olgularının cerrahi tedavilerinin endoskopik yöntemle mukoza ve perikondrium ile birlikte çıkarılmasının gerekliliği literatür eşliğinde tartışıldı.Öğe Serum Vitamin D Levels in Children with Vernal Keratoconjunctivitis(TAYLOR & FRANCIS INC, 2018) Bozkurt, Banu; Artac, Hasibe; Ozdemir, Hulya; Unlu, Ali; Bozkurt, Mete Kaan; Irkec, MuratPurpose: To evaluate serum 25-hydroxyvitamin D [25(OH)D3] levels of vernal keratoconjunctivitis (VKC) children.Methods: A total of 62 non-atopic healthy children (64.5% male, mean age 10.79 3.3 years) and 29 VKC children (75.9%, mean age 12.17 2.7 years) were included in the study. Serum 25(OH)D3 levels measured by HPLC were compared between the two groups and a p value of <0.05 was considered as statistically significant.Results: The mean serum 25(OH)D3 level of VKC group was significantly lower than in the control group (11.02 +/- 5.16 ng/mL and 15.99 +/- 7.36 ng/mL, respectively) (p = 0.002). Severe vitamin D deficiency (<10 ng/mL) was detected in 48.3% of VKC children and 22.6% of the controls (p = 0.017). Time spent outdoors during daylight was higher in the control group (229.5 +/- 101.2 min) compared with the VKC group (160.7 +/- 65.9 min) (p = 0.008), and showed a significant correlation with serum 25(OH)D3 levels (Spearman rho = 0.812) (p<0.001).Conclusions: Children with VKC should be evaluated for vitamin D deficiency, which might occur secondary to sun avoidance.Öğe Solunum yollarını tutan Wegener granülomatozu; olgu sunumu(2016) Bozkurt, Mete Kaan; Bozer, Merve; Demirtaş, Ali; Dönmez, Feyzanur; Göçer, Melike; Hasanov, Emil; İyikörükçü, Şerife NurWegener granülomatozisi (WG), üst ve alt solunum yollarını tutabilen, etyolojisi tam olarak bilinmeyen multisistemik granülomatöz bir vaskülittir. Burada bilateral nasal polipozis tanısı ile opere edilen ve 3. ay takibinde bilateral nasal kavitelerde yaygın mukoza nekrozu ve akciğerde kaviter lezyonlarla WG tanısı konan 65 yaşında bir erkek hasta sunulmaktadır.Öğe Systemic Atopy and Immunoglobulin Deficiency in Turkish Patients with Vernal Keratoconjunctivitis(TAYLOR & FRANCIS INC, 2013) Bozkurt, Banu; Artac, Hasibe; Arslan, Nasha; Gokturk, Bahar; Bozkurt, Mete Kaan; Reisli, Ismail; Irkec, MuratPurpose: To determine the prevalence of systemic atopy and immunoglobulin (Ig) deficiencies in vernal keratoconjunctivitis (VKC). Methods: Sixty-seven VKC subjects (79.1% boys) with a mean age of 11.3 +/- 4.3 years were included. Serum Ig levels and specific IgE levels were measured using the nephelometric method and reversed enzyme immunoassay with sandwich ELISA technique, respectively. The patients underwent epidermal skin tests with commercial extracts. Results: Family history of atopy and associated systemic allergies were detected in 32.8 and 40.3% of the subjects, respectively. Blood eosinophilia, elevated total, and specific IgE and positive skin tests were detected in 33.8, 42.2, 50, and 35% of the subjects, respectively. Out of 62 subjects, low levels of IgA, IgG, IgM, and IgG3 were detected in 12.9, 8, 6.5, and 1.6% of the patients, respectively. Conclusion: IgE-mediated mechanisms are involved in approximately 40% of VKC patients. A new finding was the higher incidence of Ig deficiency.
