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Öğe Effect of ?-carotene on ovarium functions and ovsynch success in repeat breeder cows(KAFKAS UNIV, VETERINER FAKULTESI DERGISI, 2009) Celic, Haci Ahmet; Avci, Guelcan; Aydin, Ibrahim; Bulbul, Aziz; Bulbul, TubaThis study was carried out to determine the effect of beta-carotene on ovarian function and pregnancy rates in repeat breeder cows. Twenty-six repeat breeder Holstein cows were randomly assigned into control (n=11) and carotene (n=15) groups. Cows were fed with diet in the form of total mixed ration (39.80% neutral detergent fiber and 16.20% crude protein of dry matter). Treatment cows received an intramuscular injection of beta-carotene (1 mg/kg) simultaneously with the first GnRH injection. Largest follicle (P<0.05) and corpus luteum diameters (P<0.01) together with serum progesterone (P<0.01), beta-carotene (P<0.05) and vitamin A (P<0.01) levels were all significantly higher in the carotene group on the day of PGF2 alpha injection. At the second GnRH injection, largest follicle diameter (P<0.01), serum estradiol (P<0.01), beta-carotene (P<0.01), and vitamin A (P<0.01) levels were again higher in the carotene group. Serum estradiol (P<0.01) and beta-carotene (P<0.05) levels were still significantly higher in the carotene group at the time of Al. Ovulation response did not differ between groups after both first and second GnRH injection. The pregnancy rate was 27.2% in the control group, and 33.3% in the carotene group but this difference was not statistically significant. In conclusion, it was Suggested that beta-carotene did not have any significant effects on ovulation or pregnancy rates in ovsynch-treated repeat breeder cows; however it increased serum estradiol and progesterone levels due to increased follicle size and corpus luteum functionality, respectively.Öğe Effect of Tilmicosin on Serum Cytokine Levels in the Endotoxemia(MEDWELL ONLINE, 2009) Uney, Kamil; Er, Ayse; Avci, Gulcan Erbil; Bulbul, Aziz; Elmas, Muammer; Yazar, EnverThe effect of tilmicosin on serum cytokine concentrations were investigated in healthy and lipopolysaccharide-treated mice. The mice were divided into 3 groups. Lipopolysaccharide (250 mu g, Escherichia coli 0111:B4, intraperitoneally) was injected into the positive control group. The other 2 groups received tilmicosin (20 mg kg(-1), subcutaneously) concurrently without or with lipopolysaccharide. After treatment, serum samples were collected at 0, 1.5, 3, 6, 12 and 24 h. Serum tumor necrosis factor, interleukin-1 and interleukin-10 levels were determined by enzyme-linked immunosorbent assay. Lipopolysaccharide increased all cytokine levels in the healthy mice. Tilmicosin slightly induced interleukin-1 production in the healthy mice, while it had no effect on tumor necrosis factor or interleukin-10 productions. However, tilmicosin elevated (p<0.05) tumor necrosis factor, interleukin-1 and interleukin-10 levels in lipopolysaccharide-treated mice. In conclusion, these data suggest that tilmicosin stimulates both proinflammatory and antiinflammatory cytokines at the dose recommended for infection.Öğe Effects of ovarian steroids on oxidative stress in overiectomized rats(Selçuk Ünivesitesi Veterinerlik Fakültesi, 2012) Bulbul, Aziz; Aslan, Recep; Celik, H. Ahmet; Avci, Gulcan; Fidan, FatihAmaç: Ovariektomi yapılmış ratlarda östrojen ve progesteron hormonlarının beraber veya ayrı uygulanmasının lipid peroksidasyon, antioksidatif aktivite (AOA) ile ?-karoten, vitamin A ve C düzeyine olan etkisinin belirlenmesi amaçlandı. Gereç ve Yöntem: Araştırma overioktemi yapılmış ve her biri 10 rattan oluşan kontrol ve 3 deneme grubunda yürütüldü. Kontrol grubuna susam yağı, progesteron grubuna progesteron 2 mg/rat/gün, östrojen grubuna 17?-östradiol 10 mg/rat/gün, östrojen + progesteron grubuna 17?-östradiol 10 mg/rat/gün + progestagen 2 mg/rat/gün olarak 10 gün uygulandı. En son uygulamadan 2 saat sonra genel anestezi altındaki ratlardan alınan kan örneklerinde malondialdehit (MDA), AOA, ?-karoten, vitamin A ve C düzeyleri ölçüldü. Bulgular: Tam kan MDA düzeylerinin kontrol gruba göre östrojen grubunda azaldığı, ancak diğer deneme gruplarında fark bulunmadığı tespit edildi. Plazma AOA düzeyinin östrojen ve östrojen + progesteron gruplarında kontrol ve progesteron gruplarına göre yüksek (p<0.05) olduğu belirlendi. Plazma ?-karoten düzeyinin tüm deneme gruplarında kontrol grubuna göre azaldığı görüldü. Vitamin C düzeylerinin kontrole göre tüm deneme gruplarında yüksek olduğu bulunurken en yüksek artış östrojen ve östrojen + progesteron gruplarında saptandı. Öneri: Ovariektomi yapılmış ratlarda östrojenin antioksidan etkinliği artırarak lipid peroksidasyonunu azalttığı, progesteronun ise vitamin A ve C düzeyini artırmasına karşın lipid peroksidsyonuna etkisi olmadığı ifade edilebilirÖğe SERUM OXIDATIVE STATUS AND ADENOSINE DEAMINASE ACTIVITY IN DOGS WITH TRANSMISSIBLE VENEREAL TUMOUR(NATL VETERINARY RESEARCH INST, 2009) Aydin, Ibrahim; Bulbul, Aziz; Avci, Gulcan Erbil; Celik, Haci AhmetTen adult healthy hitches and 10 bitches with transmissible venereal tumour were investigated. Scrum malondialdehyde, nitric oxide, antioxidant activity, vitamin C, retinol, beta-carotene, adenosine deaminase activity, oestradiol-17 beta. progesterone, and cortisol were determined. Oxidative damage and increased adenosine deaminase activity were (P<0.05) demonstrated in bitches with the tumour compared to healthy bitches. In conclusion, antioxidant supplementation may be useful in the treatment of bitches with transmissible venereal tumour.Öğe Tulathromycin disturbs blood oxidative and coagulation status(ACADEMIC JOURNALS, 2011) Er, Ayse; Ulutas, Elmas; Altan, Feray; Cetin, Gul; Bulbul, Aziz; Elmas, Muammer; Yazar, EnverThe aim of this study was to determine the effect of tulathromycin on serum oxidative status and coagulation factors in rabbits. Tulathromycin was administered to eight rabbits, and blood samples were obtained 0, 1, 5, 10 and 15 days after treatment. Indicators of serum oxidative status (malondialdehyde, nitric oxide, superoxide dismutase, retinol and beta-carotene) and coagulation values (antithrombin III, fibrinogen) were measured after tulathromycin treatment. In addition, routine serum biochemical values (creatine kinase-MB, lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase, creatinine, blood urea nitrogen, cholesterol, triglyceride, high density lipoprotein, amylase, total protein, albumin, glucose and calcium), haemacell counts (white and red blood cells) and arterial blood gas parameters (packed cell volume, hemoglobin, pH, partial pressure of carbon dioxide, partial pressure of oxygen, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess in vivo, base excess in vitro, oxygen saturation, sodium and potassium) were also determined. Tulathromycin increased (P < 0.05) the levels of malondialdehyde, nitric oxide and superoxide dismutase activity, and decreased (P < 0.05) the level of antithrombin III. In conclusion, tulathromycin may cause oxidative damage and coagulation disorders during the treatment period.
