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Öğe High catalase and low thiol levels in adult- ADHD patients(2014) Alpak, Gökay; Selek, Salih; Bulut, Mahmut; Bülbül, Feridun; Ünal, Ahmet; Virit, Osman; Kılıç, Osman Hasan Tahsinmaç: Erişkin dikkat eksikliği ve hiperaktivite bozukluğunun (E-DEHB) yaygınlığı %5 olarak tahmin edilmektedir. DEHB etyolojisine ilişkin bir çok hipotez vardır. Çocukluk çağı DEHB’nin nörobiyolojisine ilişkin bir çok araştırma yapılmış olmasına rağmen E-DEHB çalışmaları nispeten azdır. Birçok çalışmada oksidan aracılı nöronal hasarın birçok psikiyatrik hastalığın patofizyolojisinde rol oynayabileceği belirtilmiştir. Daha önce E-DEHB’de oksidatif stres çalışılmış ve sonuçlar bu rolü desteklemektedir. Bu çalışmada E-DEHB hastalarında katalaz (KAT) ve tiyol sevilerini çalışmayı ve sağlıklı kontrollerle karşılaştırmayı amaçladık. Yöntem: İki psikiyatrist tarafından uygulanan Erişkin DEH/DEHB DSM IV-Dayalı Tanı Tarama ve Ölçme Testinin Turgay’ın Türkçe versiyonuna göre tanı alan 25 E-DEHB hastası ve 25 sağlıklı kontrol dahil edildi. Denekler kesinlikle kan alımı öncesindeki günün 20:00’dan sonra herhangi bir madde alımı ve fiziksel egzersizden men edildiler. KAT ve tiyol çalışma gruplarının plazma örneklerinden ölçülmüştür. Bulgular: Hasta ve kontrollerin yaş, cinsiyet, ve beden kütle endeksleri homojenlik göstermiştir ve gruplar arasında fark yoktu. Toplam puan ve alt ölçek skorları ile belirtilen biyokimyasal parametreler arasında herhangi bir ilişki olmadığı saptandı. Hasta grubunda kontrol grubuna göre ortalama KAT düzeyleri daha yüksek ve Tiyolle düzeyleri daha düşüktü (sırasıyla; 0.001, 0.001). Psikiyatrik ekhastalığı olan hastalarla saf E-DEHB hastaları KAT (sırasıyla; 11.490.28, 11.510.40) ve tiyol (sırasıyla; 0.220.05, 0.250.03) seviyeleri açısından karşılaştırıldığında herhangi bir fark tespit edilmedi (sırasıyla; 0.865, 0.174). Sonuç: Çalışmamızın sonuçları tiyol sevilerindeki düşüşün KAT seviyelerindeki yüksekliğine bir tepki sonucu olduğu ve tiyolün çalışmamızda pro-oksidan gibi davrandığı işaret ediyor olabilir. Bu çalışma E-DEHB ve oksidatif stres arasındaki ilişkiyi aydınlatmak için yapılmış ilk aşama çalışmalarından biri olarak kabul edilebilir. Bu ilişkiyi net olarak ortaya koyacak ileri çalışmalara ihtiyaç vardır.Öğe High Catalase and Low Thiol Levels in Adult-ADHD Patients(KURE ILETISIM GRUBU A S, 2014) Alpak, Gökay; Selek, Salih; Bulut, Mahmut; Bülbül, Feridun; Ünal, Ahmet; Virit, Osman; Kılıç, Osman Hasan TahsinObjective: The prevalence of Adult attention-deficit/hyperactivity disorder (A-ADHD) has been estimated as to be around 5%. There are several hypotheses regarding the etiology of ADHD. Although numerous researches have been conducted regarding neurobiology of pediatric ADHD, A-ADHD studies were relatively few. Many studies have indicated that oxidant mediated neuronal damage may play a role in the pathophysiology of various psychiatric disorders. Recently, oxidative stress has been studied in A-ADHD and there is an accumulating evidence to support its' role. In the present study, we aimed to evaluate catalase (CAT) and thiol levels in A-ADHD patients and compare with healthy controls. Materials-Methods: Twenty-five A-ADHD patients from Gaziantep University, diagnosed according to Turgay's Turkish version of Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale by two psychiatrists, and 25 healthy volunteer controls were included. The subjects strictly refrained from any substance intake and physical exercise after 08:00 p.m. on the day before collection. CAT and Thiol levels were measured in plasma samples of study groups. Results: Age, gender, and body mass indexes of patients and controls have shown homogeneity and there were no differences between the groups. Total score and subscores were not correlated with any of the mentioned biochemical parameters. The mean CAT levels in patients with ADHD were significantly higher and Thiol levels were lower than those of controls (<0.001, <0.001, respectively). When the comorbid patient group compared with pure A-ADHD patients in terms of CAT (11.49 +/- 0.28, 11.51 +/- 0.40, respectively) and thiol (0.22 +/- 0.05, 0.25 +/- 0.03, respectively) levels there were not found any significant differences (p=0.865, p=0.174, respectively). Conclusions: The results of the present study may indicate that thiol levels may be decreased with in reaction of increased CAT levels and thiol act like a pro-oxidant. This study may be considered as one of the initial phase studies that lighten the relationship between oxidative stress and A-ADHD.There is a need for further studies that will prove this relationship exactly.Öğe Malondialdehyde levels in adult attention-deficit hyperactivity disorder(CMA-CANADIAN MEDICAL ASSOC, 2007) Bulut, Mahmut; Selek, Salih; Gergerlioglu, H. Serdar; Savas, Haluk A.; Yilmaz, H. Ramazan; Yuce, Murat; Ekici, GiyasettinObjective: To evaluate the biochemical basis of adult attention-deficit hyperactivity disorder (A-ADHD), we compared lipid peroxidation status in the plasma of A-ADHD patients, and that of control subjects without A-ADHD by quantifying the levels of malondialdehyde (MDA), an end product of fatty acid oxidation. We aimed to examine the association between MDA and A-ADHD. Method: The study comprised 20 A-ADHD patients from Gaziantep University Sahinbey Research Hospital Psychiatry Clinic, diagnosed by 2 psychiatrists (H.A.S. and S.S.) according to the Turkish version of the adult ADD/ADHD DSM-IV-Based Diagnostic Screening and Rating Scale, and 21 healthy volunteers. Malondialdehyde levels were measured in plasma samples of both study groups, Results: The mean (standard deviation [SD]) MDA levels in patients (2.44 [0.84] nmol/mL) were significantly higher than those of control subjects (0.36 [0.20] nmol/mL) (t = 11.013, of = 39, p < 0.01). MDA levels were correlated with overall number of criteria met (n = 20, p = 0.01, Ro = 0.56) and total hyperactivity/impulsivity score(n = 20, p = 0.02, Ro = 0.51). Conclusion: The fact that MDA levels were increased in A-ADHD could be an indication of increased oxidative stress in this disease. We suggest that such changes may have a pathological role in A-ADHD. This is the first study evaluating the MDA levels in A-ADHD, and our findings may provide a scientific guide for the further clinical enzymologic and biochemical studies on this disorder.Öğe Oxidative imbalance in adult attention deficit/hyperactivity disorder(ELSEVIER SCIENCE BV, 2008) Selek, Salih; Savas, Haluk A.; Gergerlioglu, H. Serdar; Bulut, Mahmut; Yilmaz, H. RamazanObjective: There are few studies evaluating the biochemical basis of adult attention deficit/hyperactivity disorder (A-ADHD). In the present study, we evaluated whether nitric oxide (NO), an oxidant, level and superoxide dismutase (SOD), an antioxidant, activity are associated with A-ADHD or not. Methods: Twenty A-ADHD patients from Gaziantep University Sahinbey Research Hospital, Psychiatry Clinic, diagnosed according to The Turkish version of Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale by two psychiatrists (H.A.S. and S.S.), and twenty-one healthy volunteer controls were included. Blood samples were collected; NO levels and SOD activities were measured. Results: The mean NO levels in patients were significantly higher than those of controls and SOD activity of patients was significantly lower than controls. Conclusions: Remarkable high levels of oxidant NO, and low SOD activities suggest an oxidative imbalance in A-ADHD. This is the first study evaluating the oxidative metabolism in A-ADHD. (C) 2008 Elsevier B.V. All rights reserved.Öğe Oxidative Imbalance in Adult Attention Deficit/Hyperactivity Disorder -- 2(ELSEVIER SCIENCE INC, 2009) Selek, Salih; Savas, Haluk A.; Gergerlioglu, Hasan Serdar; Bulut, Mahmut; Yilmaz, H. Ramazan[Abstract not Available]
