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    The effect of dexmedetomidine in the prefrontal cortex of rabbits after subarachnoidal hemorrhage
    (UNIVERSITATSVERLAG ULM GMBH, 2006) Eser, Olcay; Cosar, Murat; Fidan, Huseyin; Sahin, Onder; BuyukbaS, Sadik; Ela, Yuksel; Songur, Ahmet
    Background: This study was undertaken to examine the possible neuroprotective effect of dexmedetomidine in the prefrontal cortex of vasospastic subarachnoid hemorrhage (SAH) rabbits. Materials and Methods: Experimental SAH was performed to the 12 of 18 New Zealand rabbits by injecting 0.9 ml of autologous arterial blood/1 kg of body weight to cisterna magna. Craniotomy procedure was performed to the rest 6 rabbits (control group) (Group A) except performing experimental SAH. Forty eight hours after SAH was established, 5 mL/kg/hour 0.9% sodium chloride were infused to the SAH-alone group (n=6) (Group B) and 5 mu g/kg/h dexmedetomidine were infused to the SAH-dexmedetomidine group (n=6) (Group C) for 2 hours. Rabbits of all groups were sacrificed via penthotal after 24 hours following this drug administration processes. Brains were removed from the skull totally, prefrontal cortices were blocked from the right hemisphere for histopathological study, and prefrontal cortex of left hemispheres were dissected for biochemical analyses. So, malondialdehyde levels, activities of xantine oxidase, and superoxide dismutase were studied from the left prefrontal cortex. Results: The histopathological results showed that dexmedetomidine has neuroprotective effect in SAH induced prefrontal cortex injuries. The antioxidant parameters also supported the neuroprotective effect of dexmedetomidine. Conclusion: The present study showed the neuroprotective effect of dexmedetomidine in the prefrontal cortex of rabbits after vasospastic subarachnoid hemorrhage.