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    Effect of iloprost on adrenal medullary grafts in central nervous system transplantation and apoptosis
    (RIYADH ARMED FORCES HOSPITAL, 2007) Caglar, Sukru; Torun, Fuat; Erdemli, Esra; Torun, Ayse N.
    Objective: To investigate whether iloprost, a stable analog of prostacyclin, is useful for the preservation of neural grafts in transplantation surgery. Methods: This study was conducted at the Microsurgery Laboratory of the Department of Neurosurgery, Faculty of Medicine, Ankara University, Ankara, Turkey in 2003. The animals (rabbits) were divided into 3 groups. In group I, autografts taken from the adrenal medulla were stored in 0.9% sodium chloride (NaCl) solution for 45 minutes before transplantation. In group II, autografts taken from the adrenal medulla were stored in iloprost solution (50 ng/ ml) for 45 minutes before transplantation. Graft transplantation was not performed in the third group. Results: In group 1, the grafts partially preserved their viability. In group II, the large adrenal medullary cells had evident euchromatin nuclei fused with neurons, and there was an increase in vascularization. Conclusions: Three weeks after transplantation surgery, it was determined that iloprost maintained the viability of the graft tissue and probably prevented apoptosis, and facilitated the integration of the graft tissue into the host brain.
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    The lumbar roots and pedicles: a morphometric analysis and anatomical features
    (ELSEVIER SCI LTD, 2008) Torun, Fuat; Tuna, Hakan; Buyukmumcu, Mustafa; Caglar, Sukru; Baysefer, Alper
    The objective of this study was to conduct a morphometric analysis of the lumbar nerve roots and surrounding structures. In this investigation, the lumbar roots were studied in 14 cadavers (70 lumbar vertebrae). Lumbar pedicle heights and widths were measured at every level of the lumbar vertebrae. The largest mean root diameter was 5.6 mm (L5 root) and the smallest 3.5 mm (L1 root). With regard to the root-dura exit angle, the widest was measured at L1 as 26.2 +/- 1.6 degrees and the narrowest at L5 as 16.3 +/- 2.4 degrees. The widest lumbar pedicle was measured at L5 as 17.1 +/- 4.2 mm and the narrowest at L1 as 8.4 +/- 1.8 mm. The longest lumbar pedicle was measured at L2 as 15.3 +/- 2.2 mm and the shortest at L4 as 13.8 +/- 2.3 mm. Quantitative measurements of lumbar root diameters, their exit angles from the dura, and lumbar pedicle heights and widths in anatomical dissection models may help us to gain a deeper understanding of the pathologies of this region and positively influence the success of surgical interventions. (c) 2007 Elsevier Ltd. All rights reserved.