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    The effects of early and late feeding on healing of esophageal anastomoses: An experimental study
    (ELSEVIER IRELAND LTD, 2011) Yurtcu, Muslim; Toy, Hatice; Arbag, Hamdi; Caglayan, Osman
    Objective: To investigate the effects of postoperative late and early feeding on the healing of experimental esophageal anastomosis (EA). Methods: Twelve New Zealand rabbits were divided equally into 2 groups: late feeding (LF) and early feeding (EF). A 1-cm-length of the cervical esophagus was resected through a cervical incision, and then anastomosis was performed. The LF group was fed parenterally for 6 days and orally (per oral route) after esophagography on postoperative day 7 as long as there was no esophageal leakage. The EF group was fed orally (per oral route) 24 h after esophageal repairs (ERs), and esophagography was carried out on postoperative day 7 to check the ERs. The rabbits were sacrificed to evaluate bursting pressure (BP), diameter of the esophageal lumen (DOTEL), tissue hydroxyproline (HP), and wound healing scores (WHSs) in the anastomosis lines 8 weeks later. Results: In the LF group, BP and DOTEL were significantly lower than they were in the EF group, and HP was significantly higher than it was in the EF group. WHSs in the LF group were not higher than they were in the EFgroup. Conclusions: Early feeding is superior after EA as shown by increased DOTEL and BP levels, but causes decreased HP levels. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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    Effects of platelet rich plasma on colonic anastomosis
    (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008) Yol, Serdar; Tekin, Ahmet; Yilmaz, Hueseyin; Kuecuekkartallar, Tevfik; Esen, Hasan; Caglayan, Osman; Tatkan, Yueksel
    Purpose. To investigate the effect of platelet-rich plasma (PRP) on tissue maturation and wound healing in experimental colonic anastomosis. Materials and methods. Thirty Sprague Dawley rats were divided into three groups of 10 rats each. Group I (control group) was subjected to colon anastomosis only. Group II (PRP group) was subjected to colon anastomosis and topical PRP was applied. Group III (Bioglue group) was subjected to colon anastomosis and topical tissue sealant was applied (Bioglue; Cryo-life, Kennesaw, GA). The rats were sacrificed on postoperative day 7, and the bursting pressure of the anastomosis and tissue hydroxyproline levels were measured; histopathological changes on the anastomosis line were also examined. Results. The bursting pressure was statistically higher in the PRP group than in the control and Bioglue groups (P < 0.05). The hydroxyproline levels were also statistically higher in the PRP group than in the control and Bioglue groups (P < 0.05). Histopathologically, there was less inflammatory cell infiltration, intensive fibroblast development, and rich collagen production in the PRP group. Conclusion. PRP may be used in colon anastomosis, especially in patients with impaired wound healing, to obtain a better anastomotic strength. (c) 2008 Elsevier Inc. All rights reserved.
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    Surgical management with or without a nasogastric tube in esophageal repairs
    (ELSEVIER IRELAND LTD, 2012) Yurtcu, Muslim; Toy, Hatice; Arbag, Hamdi; Caglayan, Osman
    Objective: The aim of the study was to compare surgical management with or without a nasogastric tube (NGT) to prevent anastomotic stricture that occurred following esophageal repairs (ERs). Methods: Twelve New Zealand rabbits were divided equally into 2 m: with a NGT (experimental group) and without a NGT (control group). A 1-cm-length of the cervical esophagus was resected through a cervical incision and then anastomosis was performed using the NGT and keeping it in place for 6 days in the experimental group. The same procedures were performed in the control group. Both groups were fed parenterally for 6 days and orally after esophagography on postoperative day 7 as long as there was no esophageal leakage. The rabbits were sacrificed to evaluate diameter of the esophageal lumen (DOTEL), bursting pressure (BP), tissue hydroxyproline (HP) and wound healing scores (WHSs) in the anastomosis lines 8 weeks later. Results: In the experimental group, DOTEL, BP, and HP were significantly lower than they were in the control group. WHSs in the experimental group were not higher than they were in the control group. Conclusions: Surgical management without a NGT is more effective than management with a NGT in ERs as shown by increased DOTEL, BP, and HP levels. (C) 2011 Elsevier Ireland Ltd. All rights reserved.