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Öğe DIFFERENTIAL DIAGNOSIS OF HYPERTHYROIDISM(NOVA SCIENCE PUBLISHERS, INC, 2010) Cakir, Mehtap[Abstract not Available]Öğe Do We Need to Replace GH to Correct Anemia in Hypopituitarism?(ENDOCRINE SOC, 2014) Kulaksizoglu, Mustafa; Ipekci, Suleyman Hilmi; Gonulalan, Gulsum; Ozturk, Mine; Kaya, Ahmet; Gonen, Mustafa Sait; Cakir, Mehtap[Abstract not Available]Öğe The Effect of Hypothyroidism on Color Contrast Sensitivity: A Prospective Study(KARGER, 2015) Cakir, Mehtap; Ozturk, Banu Turgut; Turan, Elif; Gonulalan, Gulsum; Polat, Ilker; Gunduz, KemalBackground: Thyroid hormone has been shown to control retinal cone opsin expression, the protein of color vision, in adult rodents. Objectives: The aim of this study was to evaluate the effect of hypothyroidism on color contrast sensitivity in adult overt hypothyroid patients. Methods: Thirtyeight overt hypothyroid (31 females, 7 males) subjects and 20 euthyroid (16 females, 4 males) controls were studied prospectively. Color vision examination was performed by Chromatest, a software program analyzing the tritan (blueyellow) color contrast threshold (tritan CCT) and protan (redgreen) color contrast threshold (protan CCT). Color contrast sensitivity analyses of hypothyroid subjects were performed on admission and after L -thyroxine treatment when biochemical euthyroidism was achieved. Results: After a median period of 90 (90-210) days, 24 (19 females, 5 males) patients were euthyroid and eligible for a second color vision examination. Baseline tritan CCT and protan CCT values were significantly higher in the hypothyroid group compared to euthyroid controls, which clinically translates into impaired color contrast sensitivity (p < 0.001 and p < 0.001, respectively). There was a significant decrease in tritan CCT (p = 0.002) and protan CCT (p < 0.001) values in the hypothyroid group after euthyroidism was achieved, which denotes improvement in color contrast sensitivity. Conclusions: It is a novel finding of the current study that color contrast sensitivity is impaired in hypothyroidism and significantly improves after euthyroidism is achieved. (C) 2015 European Thyroid Association Published by S. Karger AG, BaselÖğe Medullary Thyroid Cancer: Molecular Biology and Novel Molecular Therapies(KARGER, 2009) Cakir, Mehtap; Grossman, Ashley B.Medullary thyroid cancer (MTC) arises from neural-crest-derived parafollicular C cells of the thyroid gland and accounts for approximately 4% of all thyroid cancers. Up to 25-30% of MTC cases occur as inherited disorders while the remaining cases represent the sporadic form of the disease. In this review, the structure and signalling properties of the RET protooncogene in its wild-type and mutant forms, and its role in hereditary and sporadic MTC, are discussed. A full data search was performed through PubMed over the years 2000-2008 with the key words 'medullary thyroid cancer, treatment, molecular biology, RET, molecular mechanism', and all relevant publications have been included, together with selected publications prior to that date. We also review novel therapies for metastatic MTC, especially the tyrosine kinase inhibitors which have activity at multiple receptor subtypes, and summarize the current ongoing trials in this area. While such tyrosine kinase inhibitors, particularly those affecting RET activity such as vandetanib, sorafenib and sunitinib, are promising, the low rate of partial responses and absence of complete responses in all of the various trials of monotherapy emphasize the need for new and more effective single agents or combinations of therapeutic agents with acceptable toxicity. Copyright (C) 2009 S. Karger AG, BaselÖğe The molecular pathogenesis and management of bronchial carcinoids(TAYLOR & FRANCIS LTD, 2011) Cakir, Mehtap; Grossman, AshleyAreas covered: The molecular biology and novel molecular pathways and drug targets in bronchial carcinoids are reviewed in this paper. A full data search is performed through PubMed over the years 2000 -- 2010 with key words ''neuroendocrine tumors of the lung, bronchial carcinoid, lung carcinoid, foregut carcinoid, pulmonary carcinoid, pulmonary NETs, lung NETs, molecular biology, autoradiography, nuclear medicine, treatment''; all relevant publications are included, together with selected publications prior to that date. Expert opinion: Although lying at the benign end of the spectrum of pulmonary NETs, bronchial carcinoids can metastasize, and the pathogenesis of these tumors is poorly understood. Several intracellular signaling pathways are under investigation to define new targets for the successful treatment of these tumors. In terms of treatment, further research should additionally focus on the already known but promising drug options.Öğe Nerve growth factor levels in autoimmune thyroid diseases(ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2007) Cakir, Mehtap[Abstract not Available]Öğe RE: TESTOSTERONE LEVELS AMONG MEN WITH SPINAL CORD INJURY: RELATIONSHIP BETWEEN TIME SINCE INJURY AND LABORATORY VALUES(LIPPINCOTT WILLIAMS & WILKINS, 2009) Cakir, Mehtap[Abstract not Available]Öğe Serum CXCL10 levels and neuromuscular manifestations in patients with autoimmune thyroid diseases(TAYLOR & FRANCIS LTD, 2011) Cakir, Mehtap; Levendoglu, Funda; Kiyici, Aysel; Coskun, YaseminObjective: Serum C-X-C motif chemokine 10 (CXCL10) levels have been shown to be elevated in autoimmune thyroid diseases (AITD). This study sought to determine whether newly diagnosed AITD patients with neuromuscular findings had higher levels of CXCL10 than those without neuromuscular manifestations. Design: A total of 80 patients were recruited to the study, which included treatment-naive hypothyroid Hashimoto's thyroiditis (n == 19) and hyperthyroid Graves' disease (GD; n == 21), euthyroid thyroid autoantibody-positive (n == 20) and -negative (n == 20) patients. Methods: All patients underwent a thorough sensorimotor and neuromuscular examination. Serum samples were kept in -- 20 degrees A degrees C for further CXCL10 measurements with ELISA. Results: There was a significant difference with regard to serum CXCL10 levels only between GD and euthyroid thyroid autoantibody-negative patient groups [187(12-418) vs. 37.5(2-542) pg/ml, p < 0.05]. However, a comparison of newly diagnosed AITD patients with and without neuromuscular manifestations in terms of serum CXCL10 levels yielded no significant difference. When a correlation of existence of a neuromuscular manifestation and serum CXCL10 levels was evaluated, a significantly positive correlation was noted between carpal tunnel syndrome (CTS) and serum CXCL10 levels [207 (95-748) pg/ml in CTS-positive vs. 117 (2-977) pg/ml in CTS-negative patients, p < 0.05]. Conclusions: In this study, from a number of neuromuscular manifestations, only the existence of CTS correlated with significantly higher CXCL10 levels in the whole study group. Further studies with larger numbers of patients with autoimmune-based hyper- and hypothyroidism may better clarify the hypothesis regarding a relationship between serum CXCL10 levels and neuromuscular manifestations of AITD.Öğe Targeting MAPK (Ras/ERK) and PI3K/Akt pathways in pituitary tumorigenesis(TAYLOR & FRANCIS LTD, 2009) Cakir, Mehtap; Grossman, Ashley B.Background: Pituitary adenomas are common intracranial neoplasms, comprising 10 - 15% of all brain tumors. Data from autopsy studies suggest that pituitary adenomas develop in 17 - 25% of the population. Nevertheless, the pathogenesis of sporadic pituitary tumors still remains obscure. Objective: In this review, the roles of MAPK (mainly Ras/extracellular signal-regulated protein kinase (ERK)) and PI3K/Akt signaling pathways in pituitary tumorigenesis are summarised. Methods: A full data search was performed through PubMed over the years 2000 - 2009 with key words I pituitary, pituitary tumor, molecular biology, Akt, MAPK, PI3K, ERK', and all relevant publications have been included, together with selected publications prior to that date. Growth factor receptor mutations and overexpression, G protein mutations, other signaling pathway abnormalities or genetic syndromes associated with pituitary tumors are not discussed as these topics are behind the scope of this review. Conclusions: There are preclinical data and human pituitary tumor studies that are compatible with increased Ras/ERK and/or PI3K/Akt pathway activity in pituitary tumors. Future research focusing on scaffold proteins and signaling modulators regulating these pathways may help identify the initiating transforming events and accordingly new strategies may be developed targeting these pathways in pituitary tumors.Öğe Thyroid Hemiagenesis with Graves' Disease, Graves' Ophthalmopathy and Multinodular Goiter(JAPAN SOC INTERNAL MEDICINE, 2009) Cakir, Mehtap; Gonen, Sait; Dikbas, Oguz; Ozturk, BanuThyroid hemiagenesis is a rare congenital anomaly in which one of the thyroid lobes with or without isthmus fails to develop. Here we present a woman patient with thyroid hemiagenesis, Graves' disease and ophthalmopathy with nodular goiter. Fine needle aspiration biopsy of the dominant nodule was suspicious of malignancy. The patient was referred for surgery for total thyroidectomy. Histopathological examination of the surgical material revealed benign features. The present case confirms that, although rare, a number of concomitant thyroid disorders can exist in a single patient with thyroid hemiagenesis just as it is seen for a normally developed thyroid gland.
