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Öğe Cerebral venous sinus thrombosis in an adolescent with Ewing sarcoma(SPRINGER, 2008) Unal, Ekrem; Yazar, Abdullah; Koksal, Yavuz; Caliskan, Umran; Paksoy, Yahya; Kalkan, ErdalBackground Although thromboembolic complications are common in adult patients with malignant diseases, cerebral venous sinus thrombosis has been rarely described in cancer afflicted pediatric and adolescent population. Case history A 16-year-old adolescent girl referred for complaints of pain and swelling on her left leg. On physical examination, a solid tibial mass was discovered. After the diagnosis of Ewing sarcoma with a tru-cut biopsy, chemotherapy protocol consisting of cisplatin, ifosfamide, adriamycine, and vincristine was started. During the first course of the treatment, the patient expressed headache, diplopia, and ptosis. Contrast-enhanced magnetic resonance (MR) images and MR angiography showed superior sagittal and transverse sinus thromboses. After anticoagulant therapy, the thromboses disappeared within 1.5 months. She received her chemotherapy protocol with the anticoagulant prophylaxis. After a follow-up period of 12 months, she is still in a good neurological recovery without any sequel. Conclusion Children and adolescents with cancer should be monitored closely for thrombotic complications. We discuss this uncommon case to draw attention to the importance of early diagnosis and adequate treatment of intracranial thrombosis in childhood cancer, and we review the relevant literature.Öğe Dysgerminoma in a child with ataxia-telangiectasia(TAYLOR & FRANCIS INC, 2007) Koksal, Yavuz; Caliskan, Umran; Ucar, Canan; Yurtcu, Muslim; Artac, Hasibe; Ilerisoy-Yakut, Zeynep; Reisli, IsmailAlaxia - telangiectasia is an autosomal recessive disease characterized by progressive cerebellar ataxia, oculocutaneous telangiectasia, immunodeficiency, high incidence of cancer; and increased sensitivity to ionizing radiation. The authors report a case of dysgerminoma in a child with high alpha-fetoprotein, CA125 and beta-human chorionic gonadotropin, who has been followed-up for ataxia-letangiectasia for 2 years.Öğe Familial Hemophagocytic Lymphohistiocytosis Type IV: Possible Founder Effect in Syntaxin 11 Gene Common Mutation Endemic to Turkish Population(AMER SOC HEMATOLOGY, 2008) Caliskan, Umran; Guler, Elif; Patiroglu, Turkan; Oner, Ahmet F.; Gurgey, Aytemiz[Abstract not Available]Öğe Hepatoblastoma in a child with neurofibromatosis type I(WILEY-BLACKWELL, 2007) Ucar, Canan; Caliskan, Umran; Toy, Hatice; Gunel, EnginA major hallmark of NF1 is the development of benign tumors, including peripheral neurofibromas, plexiform neurofibromas, gliomas of the optic tract, other low grade gliomas, and pheochromocytomas. Hepatoblastoma have not been previously reported in patients with neurofibromatosis type 1. We present a case of a 9-month-old boy diagnosed with both hepatoblastoma and neurofibromatosis type 1. Hepatoblastoma occurs in association with several well-described cancer predisposition syndromes, including familial adenomatous polyposis, Beckwith-Wiedemann syndrome, Li-Fraumeni syndrome, trisomy 18, and glycogen storage disease type 1. This paper describes a case of hepatoblastoma diagnosed in association with neurofibromatosis type 1.Öğe Hypothermia in a Child With Hodgkin Disease(LIPPINCOTT WILLIAMS & WILKINS, 2009) Koksal, Yavuz; Caliskan, Umran; Unal, EkremHypothermia is an extremely rare clinical manifestation of unknown origin in Hodgkin disease, which is generally associated with the administration of chemotherapeutic agents. We present hypothermia in a 10-year-old girl with stage IIIB nodular sclerosing type Hodgkin disease, who was previously treated with the diagnosis of immune thrombocytopenic purpura. To the best of our knowledge, this case is the first reported case of hypothermia in Hodgkin disease with combination of previously treated immune thrombocytopenic purpura Lit childhood in the English medical literature.Öğe The Investigation of Gingival Iron Accumulation in Thalassemia Major Patients(LIPPINCOTT WILLIAMS & WILKINS, 2011) Caliskan, Umran; Tonguc, Mine Ozturk; Ciris, Metin; Balta, Nihal; Kirzioglu, Fatma Yesim; Caglayan, Gurhan; Canatan, DuranBackground: Thalassemia major (TM) is an autosomal-recessive genetic blood disorder. Regular blood transfusions to improve chronic anemia caused by ineffective erythropoiesis and hemolysis lead to iron overload in many organs in TM patients. The aim of this study was to investigate the periodontal status and the iron accumulation in gingival tissues of TM patients and assess whether iron deposition in gingival biopsies could be an alternative method for the diagnosis of body iron overload in TM patients. Materials and Methods: This study was conducted on 22 TM patients and 20 healthy matched controls. Plaque index, gingival index, and probing pocket depth were measured and gingival biopsies were obtained in all subjects. Venous blood samplings and liver biopsies were carried out only in patients with thalassemia. Gingiva and liver tissue samples were evaluated histopathologically for inflammation, iron accumulation, and fibrosis. Results: There was no difference between the groups regarding periodontal health, and all patients had mild gingivitis. Gingival iron accumulation was observed only in the TM group. The iron accumulation was detected in the liver of all the patients with thalassemia. The gingival iron accumulation was correlated with neither serum ferritin levels nor hepatic iron accumulations. Conclusions: The periodontal tissues are affected by iron accumulation as well as hepatic, cardiac, and endocrine tissues in TM patients. Further studies investigating the usage of the gingival biopsy for prediagnosis of body iron overload in TM patients are needed.Öğe Kluver-Bucy syndrome in a boy with non-Hodgkin lymphoma(TAYLOR & FRANCIS INC, 2007) Unal, Ekrem; Koksal, Yavuz; Baysal, Tamer; Energin, Meltem; Aydin, Kursad; Caliskan, UmranKluver-Bucy syndrome is a rare neurobehavioral condition characterized by visual agnosia, excessive oral tendency, hypermetamorphosis, placidity, altered sexual behaviors, and changes in dietary habits. The authors report a case of Kluver-Bucy syndrome in a 10-year-old boy with non-Hodgkin lymphoma after intratechal methotrexate administration. He was treated by risperidone without any sequels.Öğe Pilomatrixoma in childhood(MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2014) Kose, Dogan; Ciftci, Ilhan; Harmankaya, Ismail; Ugras, Serdar; Caliskan, Umran; Koksal, YavuzContext: Pilomatrixoma is a benign tumor of the skin. Malignant transformation can be seen rarely in the small percentage. Aim: The aim of the following study is to attract attention to this tumor in the differential diagnosis because if it is not kept in mind it leads to both unnecessary interventions and treatments for the patient. Patients and Methods: From January 2006 to December 2012, 8 patients with pilomatrixoma were evaluated retrospectively. Results: A total of 8 pediatric pilomatrixoma patients charts were reviewed retrospectively. None of the patients had familial feature. Of 8 patients 4 (50%) were male and 4 (50%) were female. The patients age ranged from 2-18 years with a median age 11.5 years. All of the patients were admitted with the complaint of swelling at the lesion site. Two patients have multiple lesions, one of them has two and other has three lesions. A total of 11 lesion were detected in our 8 patients that 5 of them were located upper extremities (46%), 3 of them cervical region (27%), 2 of them on occipital region (18%) and 1 of them in the sacral region (9%). All lesions were excised completely. Until now, no patient had evidence of recurrence or malignant disease. Conclusion: As a result pilomatrixoma is a benign tumor, with atypical forms and unfortunately, no tumor-specific diagnostic feature except of a careful histopathological examination is available.
