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Öğe One-pot synthesis of biocompatible boronic acid-functionalized poly(methyl methacrylate) nanoparticles at sub-100 nm scale for glucose sensing(SPRINGER, 2014) Sakalak, Huseyin; Ulasan, Mehmet; Yavuz, Emine; Camli, Sevket Tolga; Yavuz, Mustafa SelmanPoly(methyl methacrylate) nanoparticles containing 4-vinylphenyl boronic acid were synthesized in one pot by surfactant-free emulsion polymerization. The nanoparticles were characterized by scanning electron microscopy and dynamic light scattering. Boron content in the nanoparticles was confirmed by electron-dispersive X-ray spectroscopy. In polymerization process, several co-monomer ratios were studied in order to obtain optimum nanoparticle size. Average hydrodynamic diameter and polydispersity index of nanoparticles versus variation of acetone percentage in the solvent mixture and total monomer concentration were investigated. The effect of boronic acid concentration in the monomer mixture on nanoparticle size and size distribution was also reported. Without further functionalization to the nanoparticles, the catechol dye, alizarin red S, was bound to boronic acid-containing nanoparticles. These nanoparticles behave as a nanosensor by which glucose or fructose can be easily detected. Dye-containing nanoparticles were undertaken displacement reaction by glucose or fructose. The glucose or fructose content was also monitored by UV-Visible spectrophotometer. Furthermore, cytotoxicity studies of boronic acid-carrying poly(methyl methacrylate) nanoparticles were carried out in 3T3 cells, which showed no toxicity effect on the cells.Öğe One-pot synthesis of sub-100 nm scale boronic acid functionalized nanoparticles for fluorescent diol sensing(AMER CHEMICAL SOC, 2014) Sakalak, Huseyin; Ulasan, Mehmet; Camli, Sevket Tolga; Yavuz, Mustafa Selman[Abstract not Available]Öğe Thermoresponsive Oligo(ethylene glycol) Methacrylate Colloids with Antifouling Surface Properties(WILEY, 2011) Yavuz, Mustafa Selman; Buyukserin, Fatih; Zengin, Zuleyha; Camli, Sevket TolgaThermoresponsive polymeric colloids attract great attention in several biotechnological applications owing to their ability to manipulate drug release characteristics in a controlled manner. Majority of these applications utilized N-isopropylacrylamide (NIPAM)-based particles for controlled drug release. Despite its advantages, such as easy chemical modification and well-documented literature, a potentially important bottleneck for NIPAM in biological applications is its tendency for nonspecific protein adsorption. Herein, we report a simple way to prepare novel thermoresponsive colloids composed of oligo(ethylene glycol) side chains via precipitation polymerization technique. In addition to displaying highly reversible thermal response, these particles also have considerably low nonspecific protein adsorption when compared with NIPAM counterparts. These crosslinked poly(ethylene glycol) ethyl ether methacrylate particles were characterized using dynamic light scattering and transmission electron microscopy. The effects of co-monomer, crosslinker and initiator on particle characteristics were investigated. Finally, particle toxicity studies were carried out using 3T3 fibroblast cell lines in MTT cytotoxicity assay. (C) 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 49: 4800-4808, 2011Öğe Thermoresponsive oligo(ethylene glycol) methacrylate nanoparticles with antifouling surface properties(AMER CHEMICAL SOC, 2013) Yavuz, Mustafa Selman; Camli, Sevket Tolga; Buyukserin, Fatih; Zengin, Zuleyha[Abstract not Available]
