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    Predictive Value of Monocyte to High-Density Lipoprotein Cholesterol Ratio (MHR) in Schizophrenia Patients with Stable Coronary Artery Disease
    (Selçuk Üniversitesi, 2022) Candemir, Mustafa; Cansız, Alparslan
    Aim: We aimed to investigate whether the monocyte/high-density lipoprotein ratio (MHR) has a potential value in the diagnosis of schizophrenia and in predicting the presence of comorbid coronary artery disease (SPCAD). Material and Method: A total of 281 participants were enrolled in this cross-sectional study. Of the participants, 85 (Group 1) were diagnosed with schizophrenia and stable coronary artery disease, and 92 (Group 2) were diagnosed with only schizophrenia. 104 (Group 3) participants in the control group had no disease. Results: MHR was highest in group 1 and higher in group 2 than in group 3. Group 1 was 18.91 (13.38-23.60) group 2: 13.68 (11.11-16.66) and group 3: 12.50 (9.13-15.68), respectively; p<0.001 for both). Conversely, HDL was the lowest in group 1, while it was lower in group 2 than in group 3 (38.52 ± 9.45 vs. 42.76 ± 9.12 vs. 47.00 ± 11.87, respectively p<0.05 for both). The cutoff value of MHR for SPCAD was 12.77, with a sensitivity of 79% and a specificity of 43%. This value for SP was 10.73, with a sensitivity of 79% and a specificity of 50%. Conclusion: High MHR which indicates an enhanced inflammation and oxidative stress was found a significant and independent marker in SP and SPCAD.
  • Küçük Resim
    Öğe
    Predictive Value of Monocyte to High-Density Lipoprotein Cholesterol Ratio (MHR) in Schizophrenia Patients with Stable Coronary Artery Disease
    (Selçuk Üniversitesi, 2022) Candemir, Mustafa; Cansız, Alparslan
    Aim: We aimed to investigate whether the monocyte/high-density lipoprotein ratio (MHR) has a potential value in the diagnosis of schizophrenia and in predicting the presence of comorbid coronary artery disease (SPCAD). Material and Method: A total of 281 participants were enrolled in this cross-sectional study. Of the participants, 85 (Group 1) were diagnosed with schizophrenia and stable coronary artery disease, and 92 (Group 2) were diagnosed with only schizophrenia. 104 (Group 3) participants in the control group had no disease. Results: MHR was highest in group 1 and higher in group 2 than in group 3. Group 1 was 18.91 (13.38-23.60) group 2: 13.68 (11.11-16.66) and group 3: 12.50 (9.13-15.68), respectively; p<0.001 for both). Conversely, HDL was the lowest in group 1, while it was lower in group 2 than in group 3 (38.52 ± 9.45 vs. 42.76 ± 9.12 vs. 47.00 ± 11.87, respectively p<0.05 for both). The cutoff value of MHR for SPCAD was 12.77, with a sensitivity of 79% and a specificity of 43%. This value for SP was 10.73, with a sensitivity of 79% and a specificity of 50%. Conclusion: High MHR which indicates an enhanced inflammation and oxidative stress was found a significant and independent marker in SP and SPCAD.