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  • Küçük Resim
    Öğe
    The Effect of Bevacizumab on Spinal Epidural Fibrosis in a Postlaminectomy Rat Model
    (TURKISH NEUROSURGICAL SOC, 2012) Karatay, Mete; Erdem, Yavuz; Koktekir, Ender; Erkoc, Yavuz Seim; Caydere, Muzaffer; Bayar, Mehmet Akif
    AIM: Spinal epidural fibrosis is an inherent result of surgical trauma after laminectomy. The conditions in which epidural fibrosis is excessive are in the etiology of failed back syndrome. There have been many attempts to prevent formation of epidural fibrosis. Bevacizumab which is an anti-angiogenic medication, inhibits the effect of VEGF and thereby decreases the new blood vessel formation and as a result prevents adhesions. This study shows the effect of bevacizumab on spinal epidural fibrosis developing after laminectomy in rats. MATERIAL and METHODS: In this study, 20 Wistar rats were used. Rats were divided into two groups; a control group, and a bevacizumab group. Three-level laminectomy was performed on the rats. Rats in the control group only had the laminectomy. In the bevacizumab group, 2.5 mg/kg bevacizumab diluted in 0.9% NaCl with a factor of 1:10 impregnated on cotton was applied on the dura topically for 5 minutes. Three weeks later, rats were sacrificed for histopathologic examination. Epidural fibrosis tissue was graded following sacrifice. RESULTS: Statistically, it was found that the bevacizumab group had significantly less epidural fibrosis compared to the control group (p<0.05). CONCLUSION: Bevacizumab reduced the spinal epidural fibrosis significantly that developed in rats after laminectomy via its anti-VEGF effect by blocking VEGF receptors.
  • Küçük Resim Yok
    Öğe
    Role of Tenoxicam in The Prevention of Postlaminectomy Peridural Fibrosis in Rats
    (2013) Karatay, Mete; Celik, Haydar; Koktekir, Ender; Karatay, Eylem; Sertbas, Idris; Yılmaz, Ali; Caydere, Muzaffer
    Amaç: Spinal cerrahi sonrası peridural fibrozis bazı durumlarda başarısız bel sendromunun altında yatan neden olabilir. Peridural fibrozisin engellenmesi amacıyla bir çok materyal denenmiştir. Nonsteroidal anti-inflamatuar ilaçlar (NSAIDs) inflamatuar ve fibroblastik yanıtı engellerler. En etkili nonsteroidal anti-inflamatuar ilaçlardan biri olan tenoksicam bir oxicam türevidir. Bu çalışma tenoksicamın topikal uygulamasının ratlarda laminektomi sonrası gelişen spinal peridural fibrozisi önlemede etkili bir yol olduğunu göstermektedir. Yöntem ve Gereç: Bu çalışmada 20 adet Wistar cinsi rat kullanıldı. Kontrol ve tenoxicam olmak üzere ratlar 2 ayrı gruba ayrıldı. Ratlara 3 seviye laminektomi yapıldı. Kontrol grubuna sadece laminektomi yapıldı. Tenoxicam kullanılan gruba ise pamuğa emdirilmiş 0.5 mg/kg tenoxicam, 0.9% NaCl ile 1:10 sulandırılarak cerrahi alanda dura üzerine topikal olarak 5 dakika süre ile uygulandı. Üç hafta sonra, ratlar histopatolojik inceleme için öldürüldü ve peridural fibrozis dokusu sınıflandırıldı. Bulgular: Kontrol grubu ile karşılaştırıldığında ameliyat sonrası üçüncü hafta tenoxicam kullanılan grupta peridural fibrozisin istatiksel olarak anlamlı derecede azaldığı görüldü (p0,05). Sonuç: Tenoxicam laminektomi yapılmış ratlarda gelişen spinal peridural fibrozisi anlamlı derecede azaltmıştır.
  • Küçük Resim Yok
    Öğe
    Role of Tenoxicam in The Prevention of Postlaminectomy Peridural Fibrosis in Rats
    (JOURNAL NEUROLOGICAL SCIENCES, 2013) Karatay, Mete; Celik, Haydar; Koktekir, Ender; Karatay, Eylem; Sertbas, Idris; Yilmaz, Ali; Caydere, Muzaffer
    Aim: The reason behind failed back syndrome in some cases may be peridural fibrosis following spinal surgery. Many attempts have been shown to stop formation of peridural fibrosis. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the inflammatory and fibroblastic response. One of the most effective nonsteroidal anti-inflammatory drugs is tenoxicam, an oxicam derivative. This study suggests that topical application of tenoxicam is an effective way of preventing spinal peridural fibrosis developing after laminectomy in rats. Material and Methods: In this study, 20 Wistar rats were used. Rats were divided into two groups; a control group, and a tenoxicam group. Three-level laminectomy was implemented on the rats. Rats in the control group only had the laminectomy. In the tenoxicam group, 0.5 mg/kg tenoxicam, which was watered down in 0.9% NaCl with a factor of 1:10 soaked on cotton, was applied on the dura topically for 5 minutes. Three weeks later, rats were killed for histopathologic examination and peridural fibrosis tissue was classified afterwards. Results: Statistically, it was found that three weeks after surgery, the tenoxicam group had significantly less peridural fibrosis compared to the control group (p<0.05). Conclusion: Tenoxicam significantly reduced the spinal peridural fibrosis that developed in rats after laminectomy.