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Öğe Enthesitis and its relationship with disease activity, functional status, and quality of life in psoriatic arthritis: a multi-center study(SPRINGER HEIDELBERG, 2020) Sunar, İsmihan; Ataman, Şebnem; Nas, Kemal; Kılıç, Erkan; Sargın, Betül; Kasman, Sevtap Acer; Alkan, Hakan; Şahin, Nilay; Cengiz, Gizem; Cüzdan, Nihan; Gezer, İlknur Albayrak; Keskin, Dilek; Mülkoğlu, Cevriye; Resorlu, Hatice; Bal, Ajda; Duruöz, Mehmet Tuncay; Küçükakkaş, Okan; Yurdakul, Ozan Volkan; Melikoğlu, Meltem Alkan; Aydın, Yıldıray; Ayhan, F. Figen; Bodur, Hatice; Çalış, Mustafa; Çapkın, Erhan; Devrimsel, Gül; Gök, Kevser; Hizmetli, Sami; Kamanlı, Ayhan; Keskin, Yaşar; Kocabaş, Hilal; Kutluk, Öznur; Şen, Nesrin; Şendur, Ömer Faruk; Tekeoğlu, İbrahim; Tolu, Sena; Toprak, Murat; Tuncer, TirajePsoriatic arthritis (PsA) is an inflammatory arthritis with distinct phenotypic subtypes. Enthesitis is assigned as a hallmark of the disease, given its significant relations to disease activity and quality of life. Our objective is to evaluate the prevalence of enthesitis and its association with some clinical parameters, particularly quality of life, using data from a national registry. Patients with PsA meeting ClASsification criteria for Psoriatic Arthritis (CASPAR) were enrolled by means of a multi-centre Turkish League Against Rheumatism (TLAR) Network Project. The following information was recorded in web-based case report forms: demographic, clinical and radiographic data; physical examination findings, including tender and swollen joint counts (TJC and SJC); nail and skin involvement; Disease Activity Score-28 for Rheumatoid Arthritis with Erythrocyte Sedimentation Rate (DAS 28-ESR); Bath Ankylosing Spondylitis Disease Activity Index (BASDAI); Maastricht Ankylosing Spondylitis Enthesitis Score (MASES); Psoriasis Area Severity Index (PASI); Bath Ankylosing Spondylitis Radiology Index for the spine (BASRI-s); Health Assessment Questionnaire (HAQ); Bath Ankylosing Spondylitis Functional Index (BASFI); Health Assessment Questionnaire for the spondyloarthropathies (HAQ-s); Psoriatic arthritis quality of Life scale (PsAQoL); Short Form 36 (SF-36); Hospital Anxiety Depression Scale (HADS); Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F); and Fibromyalgia Rapid Screening Tool (FiRST) scores. The patients were divided into two groups, namely with and without enthesitis, based on the triple Likert-type physician-reported statement of 'active enthesitis', 'history of enthesitis' or 'none' in the case report forms. Patients with active enthesitis were compared to others in terms of these clinical parameters. A total of 1130 patients were enrolled in this observational study. Of these patients, 251 (22.2%) had active enthesitis according to the clinical assessment. TJC, HAQ-s, BASDAI, FiRST and PsAQoL were significantly higher whereas the SF-36 scores were lower in patients with enthesitis (p < 0.05). Chronic back pain, dactylitis, and tenosynovitis were more frequent in the enthesopathy group (59.4%/39%, 13.1%/6.5% and 24.7%/3.4%, respectively). Significant positive correlations between the MASES score and the TJC, HAQ, DAS 28-ESR, BASDAI, FiRST and PsAQoL scores, and a negative correlation with the SF-36 score were found. When linear regression analysis was performed, the SF-36 MCS and PCS scores decreased by - 9.740 and - 11.795 units, and the FiRST scores increased by 1.223 units in patients with enthesitis. Enthesitis is an important involvement of PsA with significant relations to quality of life determined with PsAQoL and SF-36 scores. Our study found higher frequency of dactylitis and chronic back pain, and worse quality of life determined with SF-36 and PsAQoL scores in patients with enthesitis.Öğe Examining the Seroprevalance and Antiviral Prophylaxis Rate of Hepatitis B and C Virus in Rheumatic Patients Treated with Biological and Targeted Synthetic Disease Modifying Anti-rheumatic Drugs: Results from a Tertiary Center in Central Anatolia(Selçuk Üniversitesi, 2024 Şubat) Kaplan, Hüseyin; Cengiz, Gizem; Şaş, Senem; Kara, HasanABSTRACT Objective: To evaluate the epidemiological characteristics of hepatitis B virus (HBV) and hepatitis C virus (HCV) in rheumatic patients treated with biological and targeted synthetic disease modifying anti-rheumatic drugs (DMARDs). Methods: This cross-sectional study was carried out between September 2021 and April 2022 at the Rheumatology Outpatient Clinic of Erciyes University Faculty of Medicine, and it included 200 patients [113 with axial spondyloarthritis (axSpA), 18 with psoriatic arthritis (PsA) and 69 with rheumatoid arthritis (RA)]. The demographic and clinical characteristics, treatment details and viral hepatitis serology of the patients were recorded. Those not receiving biological and/or targeted synthetic DMARDs (b/tsDMARDs) were excluded. Results: The median age of the patients was 47 (39-58) years, and the median disease duration was 10 (7-15) years. Of the patients, 117 (58.5%) were female and 83 (41.5%) were male. The median duration of treatment with b/tsDMARDs was 6 (2-9) years. In the viral serological examinations, 1.5% of the patients were positive for HBsAg, 64.5% for anti-HBs, 23.5% for anti-HBc IgG, and 0.5% for anti-HCV. The anti-HBc IgG positivity rate was significantly higher in RA (34.8%) than axSpA patients (16.8%) and was similar to PsA patients (22.2%) (p = 0.023). Yet HBsAg, anti-HBs, and antiHCV serologies were similar across patient subgroups (p > 0.05). A total of 44 (22%) patients were undergoing oral antiviral prophylaxis. Three (1.5%) patients who were anti-HBc positive and HBV DNA negative were followed without antiviral treatment. There was no viral reactivation in any patient. Conclusion: Approximately one in four patients in our cohort showed anti-Hbc positivity, and almost all of them were using antiviral prophylaxis. Anti-HCV prevalence was much lower. Studies addressing viral hepatitis in rheumatic patients and/or patient subgroups, both at the national and local level, will enable rheumatologists to be more effective in managing HBV and HCV.Öğe FRI0456 The effect of gender on disease activity, functional index and quality of life in patients with axial SPA. The data of Tlar-Network PsA study(BMJ PUBLISHING GROUP, 2019) Nas, Kemal; Kılıç, Erkan; Tekeoğlu, İbrahim; Çevik, Remzi; Sargın, Betül; Kasman, Sevtap Acer; Alkan, Hakan; Şahin, Nilay; Cengiz, Gizem; Cüzdan, Nihan; Gezer, İlknur Albayrak; Keskin, Dilek; Mülkoğlu, Cevriye; Resorlu, Hatice; Ataman, Şebnem; Bal, Ajda; Duruöz, Mehmet Tuncay; Küçükakkaş, Okan; Yurdakul, Ozan Volkan; Melikoğlu, Meltem Alkan; Aydın, Yıldıray; Ayhan, Figen; Bodur, Hatice; Çalış, Mustafa; Çapkın, Erhan; Devrimsel, Gül; Gök, Kevser; Hizmetli, Sami; Kamanlı, Ayhan; Keskin, Yaşar; Kocabaş, Hilal; Kutluk, Öznur; Şen, Nesrin; Şendur, Ömer Faruk; Toprak, Murat; Tolu, Sena; Tuncer, TirajeBackground PsA is a chronic musculoskeletal disease. The prevalence of axial involvement in PsA varies according to the duration of the disease. In early stage the incidence varies between 5% and 28%, but it increases up to 25-70% in later stages of the disease. In the literature, there is limited data on the differences in disease activity, functional status and quality of life of men and women with axial PsA.Öğe Possible potential interactions between obesity, quality of life, psychological status and clinical parameters in psoriatic arthritis(BMJ PUBLISHING GROUP, 2019) Gök, Kevser; Nas, Kemal; Kılıç, Erkan; Sargın, Betül; Kasman, Sevtap Acer; Alkan, Hakan; Şahin, Nilay; Cengiz, Gizem; Cüzdan, Nihan; Gezer, İlknur Albayrak; Keskin, Dilek; Mülkoğlu, Cevriye; Resorku, Hatice; Sunar, İsmihan; Hastürk, Ajda Bal; Duruöz, Mehmet Tuncay; Küçükakkaş, Okan; Yurdakul, Ozan Volkan; Melikoğlu, Meltem Alkan; Aydın, Yıldıray; Ayhan, Figen; Bodur, Hatice; Çalış, Mustafa; Çapkın, Erhan; Devrimsel, Gül; Hizmetli, Sami; Kamanlı, Ayhan; Keskin, Yaşar; Kocabaş, Hilal; Kutluk, Öznur; Şen, Nesrin; Şendur, Ömer Faruk; Tekeoğlu, İbrahim; Toprak, Murat; Tolu, Sena; Tuncer, TirajeBackground: Psoriatic arthritis (PsA), a chronic rheumatic disease associated with reduced quality of life. Obesity is an important clinical problem which may interfere with loss of functioning and quality of life. Obesity is usually an overlooked entity in patients with PsA. Several studies were invastigated prevalence and the impact of obesity on disease activity in patients with PsA, however relationship between psychological status and quality of life have not been evaluated comparatively. Objectives: To assess the impact of obesity on quality of life, psychological status and clinical parameters in patients with PsA.Öğe Regional difference in disease burden among patients with psoriatic arthritis: A multi-center study(WILEY, 2019) Kılıç, Erkan; Kılıç, Gamze; Nas, Kemal; Sargın, Betül; Kasman, Sevtap Acer; Alkan, Hakan; Şahin, Nilay; Cengiz, Gizem; Cüzdan, Nihan; Gezer, İlknur Albayrak; Keskin, Dilek; Mülkoğlu, Cevriye; Resorlu, Hatice; Sunar, İsmihan; Bal, Ajda; Duruöz, Mehmet Tuncay; Küçükakkaş, Okan; Yurdakul, Ozan Volkan; Melikoğlu, Meltem Alkan; Aydın, Yıldıray; Ayhan, Fikriye Figen; Bodur, Hatice; Calış, Mustafa; Çapkın, Erhan; Devrimsel, Gül; Gök, Kevser; Hizmetli, Sami; Kamanlı, Ayhan; Keskin, Yaşar; Kocabaş, Hilal; Kutluk, Öznur; Şen, Nesrin; Şendur, Ömer Faruk; Tekeoğlu, İbrahim; Tolu, Sena; Toprak, Murat; Tuncer, TirajeBackground/Purpose : Psoriatic arthritis (PsA) has been de? ned as an in? ammatory arthritis associated with pso-riasis. The disease activity can be evaluated using many scales in patients with PsA. There is a great temperature difference between geographic region in Turkey. For example,the average annual air temperature in Erzurum (one of the Eastern Anatolian cities) is 5.7° C whereas in Antalya (one of the Mediterranean region cities) average temperature is 18.7° C. Furthermore, altitude of Eastern Anatolian cities is higher than Mediterranean cities.Öğe The risk factors related to mental health problems in patients with psoriatic arthritis in a large multicenter study; data from tlar-network(BMJ PUBLISHING GROUP, 2019) Kılıç, Gamze; Nas, Kemal; Kılıç, Erkan; Tekeoğlu, İbrahim; Sargın, Betül; Kasman, Sevtap Acer; Alkan, Hakan; Şahin, Nilay; Cengiz, Gizem; Cüzdan, Nihan; Gezer, İlknur Albayrak; Keskin, Dilek; Mülkoğlu, Cevriye; Resorlu, Hatice; Ataman, Şebnem; Bal, Ajda; Duruöz, Mehmet Tuncay; Küçükakkaş, Okan; Yurdakul, Ozan Volkan; Melikoğlu, Meltem Alkan; Aydın, Yıldıray; Ayhan, Figen; Bodur, Hatice; Çalış, Mustafa; Çapkın, Erhan; Devrimsel, Gül; Hizmetli, Sami; Kamanlı, Ayhan; Gök, Kevser; Keskin, Yaşar; Kocabaş, Hilal; Kutluk, Öznur; Şen, Nesrin; Şendur, Ömer Faruk; Toprak, Murat; Tolu, Sena; Tuncer, Tiraje[Abstract not Available]
