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    Deoxy-ribonucleic acid repair genes XRCC1 and XPD polymorphisms and brain tumor risk
    (RIYADH ARMED FORCES HOSPITAL, 2008) Cengiz, Sahika L.; Acar, Hasan; Inan, Ziyaeddin; Yavuz, Servet; Baysefer, Alper
    Objectives: To evaluate whether polymorphisms in the deoxy-ribonucleic acid (DNA) repair genes XRCC1 and XPD, have efficacy in the development of brain tumors. Methods: This is a case-population based study, including 135 cases of brain tumors, and 87 population based age- and gender-matched healthy controls. We examined the role of XRCC1 Arg399Gln gene and XPD Lys751Gln gene polymorphisms, in the context of brain tumor risk for the Turkish population between 2004 and 2007 at Selcuk University, Konya, Turkey. Patients with brain tumors were Subdivided into glial tumors (n=71), meningiomas (n=35), pituitary adenomas (n=21), and metastases to the brain (n=8). The diagnoses of brain tumors in all patients were analyzed by histopathological examination. Genomic DNA of leukocytes for polymerase chain reaction analysis was isolated. Results: Association of genotype of both XRCC1 Arg399Gln and XPD Lys751Gln genotypes with tumor types, tumors according to brain subtypes were, 71 (52.6%) meningiomas, 35 glial (25.9%), 21 (15.55%) pituitary adenomas, and 8 (5.9%) metastases to the brain. Between subtypes of tumors, there was a significant difference in XRCC1 Arg399Gln genotypes, and not in XPD Lys751Gln genotypes. Conclusion: The results indicated no elevated risk for brain tumors in individuals with the XRCC1 Arg399Gln and XPD Lys751Gln polymorphism risk.
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    Efficacy of Adcon-L gel or Healon-GV in epidural fibrosis after lumbar microdiscectomy
    (RIYADH ARMED FORCES HOSPITAL, 2007) Cengiz, Sahika L.; Baysefer, Alper
    Objective: To evaluate the efficacy of anti-adhesion barrier agents following lumbar microdiscectomy. Methods: Healon GV or Adcon-L was applied to a laminectomy defect overlying the duramater in 60 patients assigned to 3 randomized groups: Group I Adcon-L (n=21), Group II - Healon GV (n=21), and Group III - control group, no adhesion barrier used (n=18). We conducted this study between 2004 and 2006 at Selcuk University, Konya, Turkey. Results: No significant difference was found between the 3 groups either in the outcome measurements according to visual analogue score and the Oswestry Disability Index or in the radiological evaluation of epidural fibrosis by application of those anti-adhesion barrier agents. When comparing group III with groups I and II, we could not find a statistically significant difference in the clinical results and in the outcome measures (p > 0.01). Conclusion: The epidural application of popular anti-adhesion barriers, after lumbar microdiscectomy was not found to be effective regarding outcome measures in human spinal surgery.
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    Primary spinal intradural extramedullary hydatid cyst in a child
    (AMER PARAPLEGIA SOC, 2007) Kalkan, Erdal; Cengiz, Sahika L.; Cicek, Onur; Erdi, Fatih; Baysefer, Alper
    Background/Objective: Spinal hydatid cyst is a serious form of hydatid disease affecting less than 1% of the total cases of hydatid disease. We present a case of pathologically confirmed primary intradural spinal cyst hydatid in an otherwise healthy patient who showed no other evidence of systemic hydatid cyst disease. Case Report: An 8-year-old boy presented with back pain, left leg pain, and difficulty in walking. The patient had no other signs of systemic hydatid cyst disease. An intradural extramedullary cystic lesion was identified with magnetic resonance imaging and was shown to be a hydatid cyst by histopathologic examination after the surgical removal. Conclusion: Although extremely rare, primary intradural extramedullary hydatid cyst pathology might be the cause of leg pain and gait disturbance in children living in endemic areas.
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    An unusual association of optic hydrops and Reiter's syndrome
    (RIYADH ARMED FORCES HOSPITAL, 2007) Cengiz, Sahika L.; Baysefer, Alper
    The association of optic hydrops and Reiter's syndrome in the literature has not been mentioned previously. This syndrome characteristically consists of 3 manifestations: arthritis, urethritis, and conjunctivitis. A 42-year-old woman with a history of Reiter's syndrome presented with progressive vision disturbance in her left eye and with headache. Orbital MRI demonstrated enlarged perioptic nerve subarachnoidal space on the left side.