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    Assessment of ischemia-modified albumin level in patients with recurrent pregnancy loss during the first trimester
    (ELSEVIER, 2011) Ozdemir, Suna; Kiyici, Aysel; Balci, Osman; Goktepe, Halime; Cicekler, Humeyra; Celik, Cetin
    Objective: The finding that ischemia-modified albumin (IMA) is increased in pre-eclamptic pregnancy suggests a role for IMA as a potential biomarker for abnormal placental development related to miscarriage. This study was undertaken to evaluate IMA levels in women with recurrent pregnancy loss (RPL). Study design: This case-control study was performed between March 2008 and September 2009, at the Department of Obstetrics and Gynecology of Meram School of Medicine. Serum IMA and albumin concentrations were assessed in 43 women with a history of two or more unexplained first trimester miscarriages (group 1), and 42 healthy pregnant women (group 2) in the first trimester. IMA, adjusted IMA and albumin concentrations were compared between the groups. Statistical analysis was performed using Student's t-test and Mann-Whitney U test. Results: IMA and adjusted IMA levels were significantly higher in women with RPL (1.11 + 0.08 and 1.09 + 0.09, respectively) compared to women in group 2 (0.88 + 0.10 and 0.88 + 0.11, respectively). Albumin levels in group 1 were significantly lower compared with group 2. There was a negative correlation between IMAand albumin levels in each group. Conclusion: Maternal IMA levels appear to be elevated in women with early RPL This finding may suggest that an abnormally high hypoxic intrauterine environment may be associated with abnormal placental development that contributes to early miscarriage. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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    Association between ischemia-modified albumin, homocysteine, vitamin B-12 and folic acid in patients with severe sepsis
    (WALTER DE GRUYTER GMBH, 2012) Erdem, Said Sami; Yerlikaya, Fatma Humeyra; Cicekler, Humeyra; Gul, Mehmet
    Background: The aim of the present study was to investigate scrum ischemia-modified albumin (IMA), homocysteine, malondialdehyde (MDA), vitamin B-12 and folic acid levels in patients with severe sepsis, compared to healthy control subjects. Also, we examined associations of these parameters with high-sensitivity C-reactive protein (hsCRP) in patients with severe sepsis and healthy control subjects. Methods: This study was performed on 71 (40 male, 31 female) patients with severe sepsis aged 18-65 years and 70 (34 male, 36 female) healthy control subjects aged 18-65 years. Samples of patients were obtained at study entry within 24 h of onset of severe sepsis. Results: Serum IMA, homocysteine and MDA levels of the patients with severe sepsis were significantly higher than those of the healthy control subjects (p<0.0 I for IMA and homocysteine, and p<0.001 for MDA). There was no significant difference between serum vitamin B12 and folic acid levels of the groups. Serum hsCRP levels were positively correlated with IMA (p<0.01) and MDA (p<0.01) in the patients with severe sepsis. Conclusions: Our findings show that IMA may be useful as a prognostic biomarker because it can indicate the severity of illness in patients with sepsis.