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    Association between Serum Total Antioxidant Status and Coronary Microvascular Functions in Patients with SLE
    (WILEY, 2012) Yilmaz, Sema; Caliskan, Mustafa; Kulaksizoglu, Sevsen; Ciftci, Ozgur; Caliskan, Zuhal; Gullu, Hakan; Guven, Aytekin
    Mortality from cardiovascular disease has been found to be increased in patients with systemic lupus erythematosus (SLE). Coronary flow reserve (CFR) measurement is used both to assess epicardial coronary arteries and to examine the integrity of coronary microvascular circulation. Oxidative stress, enhancing modification of plasma lipids, is also associated with atherosclerotic events in lupus patients. Impairment of CFR and TAS has been shown to be an early manifestation of coronary atherosclerosis. Forty patients with SLE and 33 healthy volunteers were included in this study. Echocardiographic examination included left ventricular myocardial velocity measurements and coronary flow reserve (CFR) measurement. Serum total antioxidant status levels (TAS) also were measured using TAS kit. Lateral myocardial early peak velocity (Em) and lateral Em/Am ratio did not differ between the groups, but lateral myocardial atrial peak velocity (Am) was significantly higher in SLE group than the control group. Baseline coronary diastolic peak flow velocity (DPFV) of left anterior descending was similar in both the groups. However, hyperemic DPFV and CFR (2.50 +/- 0.42 vs. 3.09 +/- 0.45, P < 0.0001) were significantly lower in the SLE group than in the control group. CFR significantly and inversely correlated with CRP and significantly correlated with TAS. Subclinical coronary microvascular dysfunction can occur in SLE patients without traditional cardiovascular risk factors, probably associated with underlying inflammation and impairment of TAS. (Echocardiography 2012;29:1218-1223)
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    A different marker to determine arrhythmia potential between elite active cyclists and veterans: T peak T end
    (WILEY-BLACKWELL, 2015) Gormus, Z. Isik Solak; Isik, Bulent; Ciftci, Ozgur; Icli, Abdullah; Togan, Turhan; Aslan, Huseyin; Kutlu, Selim
    [Abstract not Available]
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    Does Mild Renal Failure Affect Coronary Flow Reserve after Coronary Artery Bypass Graft Surgery?
    (FORUM MULTIMEDIA PUBLISHING, LLC, 2014) Gunday, Murat; Ciftci, Ozgur; Caliskan, Mustafa; Ozulku, Mehmet; Bingol, Hakan; Korez, Kazim; Aslamaci, Sait
    Introduction: There are only a limited number of studies on the link between mild renal failure and coronary artery disease. The purpose of this study is to investigate the effects of mild renal failure on the distal vascular bed by measuring the coronary flow reserve (CFR) in transthoracic echocardiography after coronary artery bypass grafting (CABG). Methods: The study included 52 consecutive patients (12 women and 40 men) who had undergone uncomplicated CABG. The patients were divided into 2 groups. Group 1 included patients with a preoperative glomerular filtration rate (GFR) of 60-90 (mild renal failure), and group 2 included those with a GFR > 90. The CFR measurements were carried out through a second harmonic transthoracic Doppler echocardiography. Results: The mean age was 60.08 +/- 1.56 years in group 1 and 60.33 +/- 1.19 in group 2. The mean preoperative CFR was 1.79 +/- 0.06 in group 1 and 2.05 +/- 0.09 in group 2. The mean postoperative CFR was 2.09 +/- 0.08 in group 1 and 2.37 +/- 0.06 in group 2. There was a statistically significant difference between the 2 groups as to preoperative creatinine clearance, preoperative estimated GFR, postoperative day 7 creatinine clearance, postoperative month 6 creatinine clearance, postoperative day 7 estimated GFR, postoperative month 6 estimated GFR, preoperative CFR, and postoperative CFR (P <.05). CFR was found to be unaffected by the choice of on-pump or off-pump technique (P =.907). After bypass surgery, there was a significant increase in the mean postoperative CFR, when compared with the mean preoperative CFR (P =.001). Conclusion: In our study, we detected a decrease in CFR in patients with mild renal failure. We believe that in patients undergoing CABG for coronary artery disease, mild renal failure can produce adverse effects due to deterioration of the microvascular bed.