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Öğe Effects of PCR-confirmed subclinical paratuberculosis on retinol and beta-carotene levels in dairy cattle(UNIV AUSTRAL CHILE, FAC CIENCIAS VETERINARIAS, 2009) Civelek, T.; Celik, H. A.; Ozenc, E.; Avci, G.; Kav, K.; Cingi, C. C.; Yilmaz, O.In the present study, the effects of IS900 PCR-confirmed subclinical paratuberculosis on serum beta-carotene and retinol concentrations in dairy cattle were investigated. A total of 30 multiparous, clinically normal, paratuberculosis non-vaccinated Holstein dairy cows, ages 3 to 9 years old were tested. Fifteen of the 30 cows were diagnosed as having subclinical paratuberculosis by IS900 PCR on faecal samples (Group 1). The remaining 15 cows, negative to three independent tests for paratuberculosis, were classified as the healthy control group (Group 2). Serum retinol and beta-carotene levels were analyzed by colorimetric assays on serum samples from all 30 cows. There were no differences regarding the serum retinol and beta-carotene concentrations between cows with and without paratuberculosis.Öğe Evaluation of Ultrasonographic and Morphologic Liver Changes in Dogs With Steroid Hepatopathy(Indian Veterinary Journal, 2001) Şen, İsmail; Turgut, K.; Hatipoğlu, Fatih; Ok, M.; Civelek, T.[Abstract not Available]Öğe Investigation of Biochemical and Haematological Side-Effects of Enrofloxacin in Dogs(BLACKWELL WISSENSCHAFTS-VERLAG GMBH, 2001) Traş, B.; Maden, M.; Baş, A. L.; Elmas, M.; Yazar, E.; Civelek, T.In the present study, effects of enrofloxacin on biochemical, haematological and blood gas parameters were investigated. Changes in laboratory parameters were monitored during the treatment period. Enrofloxacin was administered (5 mg/kg intramuscularly, once daily) to 10 healthy dogs for 14 days. Acidosis and temporary increases in aspartate aminotransferase, indirect bilirubin, sodium, partial pressure of CO2 and mean corpuscular volume levels as well as decreased levels of inorganic phosphorus, ionized calcium, potassium, partial pressure of O-2 and standard bicarbonate were observed. The results of this study suggest that these observed effects of enrofloxacin on blood gas parameters should be taken into consideration in long-term use of the drug.Öğe Serum apolipoprotein B100 concentrations in dairy cows with left sided displaced abomasum(ECOLE NATIONALE VETERINAIRE TOULOUSE, 2006) Civelek, T.; Sevinc, M.; Boydak, M.; Basoglu, A.The purpose of this study was to examine the alteration in serum apolipoprotein B100 (apo B100) concentrations and to evaluate the liver steatosis in dairy cows with left sided displaced abomasum (LSDA). A total of 33 Holstein cows (9 clinically healthy and 24 with LSDA) were used. Serum concentrations of apo B100 were assayed by single radial immunodiffusion method. Serum total bilirubin, glucose, cholesterol, triglyceride, total protein, albumin and high density lipoprotein (HDL) concentrations and aspartate amino transferase (AST) and gamma glutamyl transferase (GGT) activities were measured colorimetric methods. Biopsy samples were obtained from liver under local anesthesia with percutaneous biopsy needle for histopathological examination. Serum apo B100 concentrations were significantly decreased in cows with LSDA (p < 0.001) and were associated to abnormal lipid biochemistry (marked decreases of triglyceride, cholesterol and lipoprotein concentrations, p < 0.001), and to cholestasis (significant inceases of total bilirubin concentrations (p < 0.001) and of serum GGT activities (p < 0.01)) leading to liver injury (marked increases of AST activities (p < 0.001), and decreases of total protein (p < 0.01) and albumin (p < 0.05) concentrations). Liver biopsies revealed a severe fat infiltration (41.5 +/- 2.5%) in cows with LSDA, and the degree of hepatic lipidosis was negatively correlated to apo B 100 concentrations (r = -0.591). These results suggest that the apo 13100 would be a marker for hepatic steatosis and would provide a non invasive alternative to liver biopsy for FL (fatty liver) diagnosis.
