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    COMPARISON OF SINGLE VERSUS DOUBLE INTRAUTERINE INSEMINATION
    (ELSEVIER SINGAPORE PTE LTD, 2008) Gezginc, Kazim; Goerkemli, Hueseyin; Celik, Cetin; Karatayli, Rengin; Cicek, M. Nedim; Colakoglu, M. Cengiz
    Objective: To compare the outcomes of single versus double intrauterine insemination. Materials and Methods: This prospective randomized study was carried out in 100 infertile patients. One intrauterine insemination was applied 36 hours after human chorionic gonadotropin (hCG) injection to 50 patients in the first group. To SO patients in the second group, two intrauterine inseminations were applied, of which the first was applied 24 hours after and the second 48 hours after the hCG injection. Results: In the First group, pregnancies were detected in eight patients (pregnancy rate per patient was 16%, pregnancy rate per cycle was 10.6%). In the second group, pregnancies were detected in five patients (pregnancy rate per patient was 10%, pregnancy rate per cycle was 6.4%). There was no statistically significant difference between the two groups (p > 0.05). Conclusion: Single intrauterine insemination can be considered to be more reasonable than double intrauterine insemination treatment, taking into consideration the economic cost and the psychologic trauma to the patients. However, further studies with larger sample sizes are needed in order to reveal any actual differences between the two methods. [Taiwan J Obstet Gynecol 20081-47(1):57-61]
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    Repeated in vitro Fertilization Failure and Its Relation with Thrombophilia
    (KARGER, 2009) Simur, Aynur; Oezdemir, Suna; Acar, Hasan; Colakoglu, M. Cengiz; Goerkemli, Hueyin; Balci, Osman; Nergis, Sueleyman
    Background: The objective of this study was to determine the prevalence of some thrombophilic factors and its relation to in vitro fertilization (IVF)-embryo transfer failure in women who had had three or more previously failed IVF-embryo transfer cycles. Methods: The study group included 51 consecutive women with three or more previously failed IVF-embryo transfer cycles (group 1). The control group included 50 women who conceived spontaneously with at least one uneventful pregnancy and no previous history of miscarriage. All women were tested for the presence of factor V Leiden, prothrombin (G20210A), and methylenetetrahydrofolate reductase (C677T) mutations. Results: A similar prevalence of factor V Leiden, prothrombin, and methylenetetrahydrofolate reductase mutations was found in both groups. At least one inherited thrombophilic factor was detected in 62.7% of women with repeated IVF failure and in 53.9% of women in group 2. No association between repeated IVF failure and these thrombophilic factors was found statistically. Conclusion: These data suggest that factor V Leiden, methylenetetrahydrofolate reductase and prothrombin gene mutation do not have a significant role in IVF-embryo transfer implantation failure. Copyright (C) 2008 S. Karger AG, Basel