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    Evaluation of HLA-A, -B, -Cw, and -DRB1 alleles frequency in Turkish patients with nasal polyposis
    (SAGE PUBLICATIONS LTD, 2008) Keles, Bahar; Cora, Tuelin; Acar, Hasan; Arbag, Hamdi; Inan, Ziya; Ozturk, Kayhan; Ozer, Bedri
    OBJECTIVE: To evaluate whether there is a relationship between HLA-A, -B, -Cw, and -DRB1 alleles and developing nasal polyposis (NP). STUDY DESIGN: Data from 66 patients with NP were compared with data from 100 healthy randomly selected controls. Asthma, ASA (acetylsalicylic acid) triad, polyp score, and previous sinonasal surgery were also recorded. SUBJECTS AND METHODS: Genotyping of the HLA-A, -B, -Cw, and -DRB1 alleles were performed with polymerase chain reaction (PCR) with the sequence-specific primer (SSP) method. Data were analyzed by using a Pearson chi(2) test. RESULTS: The HLA-B*07 and -Cw*12 alleles were found to be significantly higher in the NP patients compared with the control group, whereas the HLA-B*57 and HLA-Cw*04 alleles were significantly lower (P < 0.05). The HLA-A*24, HLA-Cw*12, and HLA-DRB1*04 alleles were determined to be significantly higher in the NP patients with asthma and ASA triad (P < 0.05). CONCLUSIONS: Our results show that some of the HLA alleles seem to be associated with the genetic susceptibility to develop NP in the Turkish population. (C) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.
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    Platelet glycoprotein Ib alpha gene polymorphism and massive or submassive pulmonary embolism
    (SPRINGER, 2009) Soylu, Ahmet; Tokac, Mehmet; Cora, Tuelin; Duzenli, Mehmet Akif; Acar, Hasan
    Objective The -5T/C polymorphism in the Kozak sequence of glycoprotein Ib alpha, a component of the platelet glycoprotein Ib-IX-V receptor complex, is associated with an increase in this receptor density on the surface of the platelet. This study was designed to investigate the effect of platelet glycoprotein Ib alpha Kozak polymorphism on the clinical presentation of the patients with acute pulmonary embolism. Methods Forty-two patients with pulmonary embolism were genotyped for Kozak polymorphism of the glycoprotein Ib alpha by polymerase chain reaction/restriction fragment length polymorphism. Results Carriers of the -5T/C polymorphism of glycoprotein Ib alpha were significantly over-represented in the patient group with clinically massive or submassive pulmonary embolism (odds ratio 5.5, 95% confidence interval 1.4 to 22.2, P = 0.023). Also the association between this polymorphism and massive or submassive pulmonary embolism still existed even after being adjusted for conventional risk factors. Conclusion The -5T/C polymorphism in the Kozak sequence of glycoprotein Ib alpha may present as a risk factor for clinical manifestation of pulmonary embolism in which clot burden plays an important role.