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    Diabetes mellitus-and cooling-induced bladder contraction: An in vitro study
    (2010) Atalik K.E.; Okudan N.; Gokbel H.; Kalkan S.; Cuce G.
    The effects of diabetes mellitus during cooling on ACh-and KCl-induced responses were investigated in rat urinary bladder. Diabetes was induced in the rats by 50 mg/kg streptozotocin via an intraperitoneal injection. Rats' body and bladder weights were measured. The isometric tension to ACh (10-9 -3 × 10-4 M) and KCl (5-100 mM) in strips of urinary detrusor muscle of diabetic and non-diabetic rats, in organ baths at 37 and 28°C were recorded. The body weights were significantly decreased and the bladder weights increased in STZ-induced diabetic group compared to the non-diabetic group. ACh and KCl caused concentration-dependent contractions of urinary bladders from non-diabetic and STZ-induced diabetic rats. During cooling, the sensitivity and the maximal response were significantly higher than those during 37°C, both in non-diabetic and diabetic preparations. Cooling of detrusor muscle preparations induces a graded contraction inversely proportional to the temperature in diabetic rats. It may be assumed that the cooling response involves the same mechanisms in the diabetic and non-diabetic animals.
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    Öğe
    Evaluation of TGF beta 1 expression and comparison the thickness of different aorta layers in experimental diabetes
    (2011) Cuce G.; Kalkan S.S.; Esen H.H.
    Background: It was aimed to investigate the effects of experimental diabetes on TGF ß1 expression and tunica intima and media thickness in abdominal and thoracic aorta. Methods: Fourteen three months old female rats were divided into two groups, non-diabetic and streptozotocin (STZ) induced diabetic group. Hematoxylin-Eosin and Verhoeff's Van Gieson elastic staining and TGF ß1 im-munohistochemistry staining were performed. Abdominal and thoracic intima and media thickness of aortas were measured with the oculometer. Results: Evaluation of intima and media thickness measurements showed no significant statistical differences between non-diabetic and diabetic groups. TGF ß1 expression increased significantly in thoracic diabetic (TD) group. Conclusion: The 60 day duration of diabetes is not sufficiently enough time for the development of pathological changes that could lead to thickening in aortic intima-media layers. TGF ß1 expression was negative in the abdominal aorta that can predispose to the development of atherosclerosis, which could develop overtime. This finding may be interpreted as an appropriate basis for the development of atherosclerosis. In the thoracic aorta TGF ß1 may coordinate cellular events such as tissue repair.