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Öğe Atypical gastrointestinal plasmacytomas presenting with gastrointestinal bleeding in a patient with multiple myeloma(TURKISH SOC GASTROENTEROLOGY, 2012) Gungor, Gokhan; Goktepe, M. Hakan; Kayacetin, Ertugrul; Tuna, Tuncer; Esen, Hasan; Demir, Ali[Abstract not Available]Öğe Case Study on Drug-Related Adverse Effects of Hepatitis C Therapy(Health Communications Inc, 2006) Başaranoğlu, Metin; Çelebi, Selman; Karaaslan, Hayri; Demir, AliThe case of a 46-year-old woman with chronic hepatitis C who was prescribed subcutaneous pegylated interferon once a week and oral ribavirin once a day is presented. Within 24 h after the first injection to her left arm, the patient developed pruritus and erythematous papules at the injection site and painful papules on her hands. After immediate administration of antihistamines, the pruritus and papules remitted. One wk later, after injection in the right arm, skin lesions and pruritus were seen. After the third injection to the abdomen, the patient developed a rash, and after the fourth and fifth injections to other areas of the abdomen, injection-site papules were seen. The patient had no skin reactions for the next 12 mo, with the exception of injection-site papules. Hepatitis C virus RNA was negative after 12 mo of treatment. Clearly, patience is important during hepatitis C therapy in order to avoid unnecessary examinations and to promote successful outcomes.Öğe A duodenal mass and acute pancreatitis(TURKISH SOC GASTROENTEROLOGY, 2013) Ozer Cakir, Ozlem; Biyik, Murat; Gungor, Gokhan; Ataseven, Huseyin; Demir, Ali; Tavli, Lema[Abstract not Available]Öğe Endovascular Management of Massive Gastrointestinal Bleeding Associated with Polyarteritis Nodosa(ELSEVIER SCIENCE INC, 2009) Koc, Osman; Ozbek, Orhan; Gumus, Serter; Demir, Ali[Abstract not Available]Öğe Hidatik akut pankreatit(2012) Özer, Özlem Çakır; Ataseven, Hüseyin; Demir, AliKaraciğer hidatik kistlerinin safra ağacı içine rüptürü bilinmektedir, fakat akut pankreatit nadir bir komplikasyonudur. İntrabiliyer rüptür ilk kez Dew tarafından 1928'de bildirilmiştir. İntrabiliyer rüptür hepatik hidatik kistin ciddi bir komplikasyonudur. Erişkin hastalarda insidansı %1-25 arasındadır. Bizim olgumuzda hepatik kist materyalinin ana safra kanalına göç edebileceğini ve papiller orifise impakte olup akut pankreatiti provake edebileceğini göstermeyi amaçladık. Akut pankreatitle gelen hastada ayrıcı tanıda biliyer nedenler arasında parazitik enfeksiyonların da düşünülmesi gerekmektedir.Öğe Neutrophil gelatinase-associated lipocalin in prediction of mortality in patients with hepatorenal syndrome: a prospective observational study(WILEY, 2014) Gungor, Gokhan; Ataseven, Huseyin; Demir, Ali; Solak, Yalcin; Gaipov, Abduzhappar; Biyik, Murat; Ozturk, BahadirBackground & AimsHepatorenal syndrome (HRS) is a severe complication of cirrhosis which is characterized by renal dysfunction and associated with poor survival. Neutrophil gelatinase-associated lipocalin (NGAL) is a troponin-like biomarker for human acute kidney injury. We aimed to investigate levels of plasma and urine NGAL in HRS and predictive ability of these markers for all-cause mortality, in HRS, stable cirrhosis and control subjects. MethodsA total of 64 patients with cirrhosis (8 patients with type 1 HRS, 22 with type 2 HRS, and 34 without HRS) and 23 control subjects were included in the study. Blood and urine samples were measured with Human NGAL sandwich ELISA. Patients were followed up prospectively. ResultsPatients with type 1 and type 2 HRS had significantly higher plasma and urine NGAL levels compared with stable cirrhosis and control subjects. Cox regression analysis showed that plasma NGAL and MELD-Na scores were independent predictors of mortality. ROC-curve analysis showed that the plot of the plasma NGAL, urine NGAL, MELD-Na and Child-Turcot-Pugh score could predict all-cause mortality in cirrhotic patients' area under the curve (AUC 0.819, 0.686, 0.807 and 0.795 respectively). ConclusionsNGAL could predict mortality in patients with HRS independent of other commonly used risk factors.Öğe Routinely evaluated clinical assays and laboratory tests [real test] and fibrosis stages of chronic hepatitis B and C(AVES, 2014) Bugdaci, Mehmet Sait; Korkmaz, Huseyin; Demir, Ali; Biyik, Murat; Temel, Tuncer; Gokturk, Huseyin Savas; Ozakyol, AysegulBackground/Aims: To provide a new mathematical formula to predict liver fibrosis in patients with chronic viral hepatitis. Materials and Methods: Patients with chronic hepatitis B and C who underwent liver biopsy at different centers were included in this study. Chronic hepatitis B was defined as immunopositivity for the hepatitis B surface antigen for at least 6 months, and chronic hepatitis C was defined as positivity for HCV RNA for at least 3 months. The histological features were evaluated by the histological activity index and fibrosis. Results: In total, 1299 patients were included in the study. The distribution and the mean of the parameters of the patients were as follows: 1009 patients with chronic hepatitis B with a mean age of 45 +/- 13/years [emale/male (F/M)=47.5/52.5%] and 290 patients with hepatitis C with a mean age of 52 +/- 10.3/years [F/M=61/39%]. When the cut-off value of the REAL TEST formula"[(age x pT x AST)/(PLT/1000)]/100" in patients with hepatitis B was determined to be >= 1.37, it was found that it could predict fibrosis with 79% specificity, 78% sensitivity, 85% negative predictive value (NPV), and 70% positive predictive value (PPV) (area under the curve (AUC)=0.852, 95% CI: 0.82-0.87). When the cut-off value of the REAL TEST formula in patients with hepatitis C was determined to be >= 1.99, it was found that it could predict significant fibrosis with 87% specificity, 90% sensitivity, 94.4% NPV, and 79.4% PPV (AUC: 0.95, 95% CI: 0.93-0.98) Conclusion: The REAL TEST formula results correlated with the pathological findings and may be a useful method for the evaluation of patients with chronic hepatitis B and C.Öğe SERUM AND URINE NGAL LEVELS IN PATIENTS WITH CIRRHOSIS AND HEPATO-RENAL SYNDROME(OXFORD UNIV PRESS, 2012) Gungor, Gokhan; Ataseven, Huseyin; Demir, Ali; Solak, Yalcin; Biyik, Murat; Ozturk, Bahadir; Polat, Ilker[Abstract not Available]Öğe A Splenic Hydatid Cyst Case Presented With Lumbar Pain(Japan Soc Internal Medicine, 2006) Çelebi, Selman; Başaranoğlu, Metin; Karaaslan, Hayri; Demir, AliA splenic hydatid cyst is a rare clinical entity from among abdominal hydatid cysts, even in endemic countries. Here, a case with lumbar pain due to a giant splenic hydatid cyst is presented. The importance of this case is that the patient presented at the clinic with only lumbar pain. Initial direct abdominal plain radiography showed a giant abdominal calcification in the spleen and further examinations revealed involvement of three organs: spleen, lung, and liver.
