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Öğe Association Analysis of the Gln223arg Polymorphism in the Human Leptin Receptor Gene, and Traits Related to Osas and Blood Pressure(Oxford Univ Press Inc, 2010) Küççüktürk, Serkan; Yosunkaya, Şebnem; Okur, H.; Demirel, S.; Özer, F.[Abstract not Available]Öğe Chromosomal Abnormalities in Mentally Retarded Children in the Konya Region - Turkey(Medecine Et Hygiene, 2000) Cora, T.; Demirel, S.; Acar, A.Etiology of mental retardation is diverse. 120 Students from 11 special training, education, and rehabilitation subclasses were investigated cytogenetically For determining the contribution of chromosomal abnormalities to mild mental retardation. 23 of the 120 children (19%) had chromosomal abnormalities: thirteen cases a classical trisomy 21 (the male: Female ratio was 9:4), three a balanced autosomal reciprocal translocation, one a pericentric inversion of chromosome 9, and six fragile-X syndrome (The male: female ratio was 5:1).Öğe Determination of radon concentration levels in well water in Konya, Turkey(OXFORD UNIV PRESS, 2013) Erdoğan, M.; Eren, N.; Demirel, S.; Zedef, VeyselRadon (Rn-222) measurements were undertaken in 16 samples of well water representing different depths and different types of aquifers found at the city centre of Konya, Central Turkey. The radon activity concentrations of the well water samples collected in the spring and summer seasons of 2012 were measured by using the radon gas analyser (AlphaGUARD PQ 2000PRO). The radon concentrations for spring and summer seasons are 2.290.17 to 27.251.07 and 1.440.18 to 27.451.25 Bq l(1), respectively. The results at hand revealed that the radon concentration levels of the waters strictly depend on the seasons and are slightly variable with depth. Eleven of the 16 well water samples had radon concentration levels below the safe limit of 11.11 Bq l(1) recommended by the United States Environmental Protection Agency. However, all measured radon concentration levels are well below the 100 Bq l(1) safe limit declared by the World Health Organisation. The doses resulting from the consumption of these waters were calculated. The calculated minimum and maximum effective doses are 0.29 and 5.49 Sv a(1), respectively.Öğe Effect of different egg storage times on some egg quality characteristics and hatchability of pheasants (Phasianus colchicus)(OXFORD UNIV PRESS, 2009) Demirel, S.; Kirikci, K.In this study, some quality characteristics and hatchability characteristics of 1 to 2, 3 to 4, 5 to 6, 7 to 8, 9 to 10, 11 to 12, and 13 to 14 d stored pheasant eggs were investigated. Although it was determined that the effect of storage time on egg weight, shape index, and albumen weight was not significant, the effect of storage time on eggshell weight, shell thickness, yolk weight, albumen index, yolk index, Haugh unit, shell percentage, albumen percentage, and yolk percentage was significant (P < 0.05). It was determined that prolonged storage time caused a decrease in the albumen index and Haugh unit value but an increase in the yolk index of pheasant eggs. There was no positive or negative effect of storage time on the fertility rates and hatchability of fertile eggs, but there was a negative effect of storage time on hatchability on d 8 (P < 0.05). Pheasant eggs should not be stored more than 8 d.Öğe Evaluation of smoking genotoxicity in Turkish young adults(2011) Zamani, A. G.; Durakbaşı, Hatice Gül Dursun; Demirel, S.; Acar, A.BACKGROUND: For the past few decades, it has been widely known in developed countries that tobacco is dangerous, but it is still insufficiently realized how big these dangers really are. AIMS: To determine and evaluate micronuclei (MN) frequencies of young smokers and nonsmokers in three different tissues (peripheric blood lymphoctes, buccal mucosa, and exfoliative urothelial cells) at the same time. MATERIALS AND METHODS: MN assay was performed on buccal mucosa, urothelial cells, and peripheric blood lymphocyte samples obtained from 15 healthy male smokers (>5 pack-years) and 15 healthy male nonsmoker controls who had not been exposed to any known genotoxic agent. STATISTICAL ANALYSIS USED: The statistical differences between smoker and nonsmoker groups were calculated by using student t test. The differences between smoker-group tissues were compared by ANOVA. RESULTS: It was found that MN frequency (mean value standard deviation) in oral mucosa cells from smokers and controls were 1.20 ± 0.22% and 0.26 ± 0.10%; in urothelial exfoliative cells, 1.29 ± 0.28% and 0.12 ± 0.08%; in peripheric blood lymphocytes, 1.53 ± 0.23% and 0.38 ± 0.12%, respectively. The mean MN frequencies in buccal mucosa, urothelial exfoliative cells, and peripheric blood lymphocytes were significantly higher in smokers than in those of controls (P<0.05). All tissues were affected from smoking, but the most destructive effect was seen in urothelial cells of smokers (P<0.05). CONCLUSIONS: Our data showed that cigarette smoke is a DNA damage causitive agent on exfoliative buccal mucosa and urothelial cells and peripheric blood lymphocytes of young smokers, but it has most destructive effect on urothelial cells.Öğe The Frequency of Consanguinity in Konya, Turkey, and Its Medical Effects(MEDECINE ET HYGIENE, 1997) Demirel, S.; Kaplanoğlu, N.; Acar, A.; Bodur, S.; Paydak, F.This study was conducted in the town of Konya, Turkey, on 1120 randomly selected women to find out the overall rate of consanguineous marriages among couples. The frequency of consanguineous marriages was found to be 23.2 %. It was found that 14.6% of this figure was first cousin marriages and the rest was 8.6%. Consanguineous marriages were higher among women born in villages compared to those born in provinces and the town center. Based on the findings, it was not too difficult to say: the higher the level of education of women, the lower the rate of consanguineous marriages. The number of children with an abnormality was high in consanguineous marriages, while the frequency of spontaneous abortion, still-birth and infant death remained the same.Öğe Linkage analysis of a four generation herediter spherocytosis family with spectrin deficiency(SPRINGER, 2009) Tasdemir, P.; Akarsu, N.; Demirel, S.[Abstract not Available]Öğe Micronucleus Frequencies in Buccal Mucosa, Urothelial Cells and Peripheral Blood Lymphocytes of Smokers.(NATURE PUBLISHING GROUP, 2002) Demirel, S.; Zamani, Ayşe Gül; Durakbaşı, G. H.; Acar, A.[Abstract not Available]
