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    Hyperglycemic Effect of N-Methylglucamine Antimonite (Glucantime) in Mice
    (Selçuk Üniversitesi, 1985 Ocak) Erer, Hüdaverdi; Yurdakök, Murat; Kınık, Erol; Diker, Serdar; Dilmen, Uğur; Ceyhan, Mehmet; Kutsal, Osman
    N-methylglucamine antimonite (Glucantime) was injected intramuscularly to ten albino mice in a dose of 15-30 mg/kg for the first three days and then 60 mg/kg for twelve days. Glucantime was also injected in the same manner but in double doses to another ten mice. No drug was administred to ten mice that were used as a control group. In the sixteenth day, there were hyperglycemia, parenchymatous and vacuolar degeneration, hepatocellular necrosis and inflammation in the livers of the experimental mice which were marked as a double dose group. The frequent monitoring of blood glucose of the patients with Kala-azar receiving Glucantime was suggested.