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Öğe Early and late urological complications corrected surgically following renal transplantation(WILEY, 2007) Dinckan, Ayhan; Tekin, Ahmet; Turkyilmaz, Serdar; Kocak, Huseyin; Gurkan, Alihan; Erdogan, Okan; Tuncer, MuratThe purpose of this study was to assess outcomes of urological complications after kidney transplantation operation. Nine-hundred and sixty-five patients received a kidney transplant between 2000 and 2006. In total, 58 (6.01%) developed urological complications, including urinary leakage (n = 15, 1.55%), stenosis (n = 29, 3%), vesicoureteral reflux (VUR) (n = 12, 1.2%), calculi (n = 1, 0.1%) and parenchymal fistulae (n = 1, 0.1%). Urinary leakage cases were treated by ureteroneocystostomy (UNS) via a double-J stent and stenosis cases by UNS. Fenestration was performed in patients developing lymphoceles and unresponsive to percutaneous drainage. VUR treatment was performed by ureteroneocystostomy revision or UNS. Stent usage during ureteric reimplantation was observed to reduce urinary leakage. Surgical complication rates in renal transplantation recipients according to donor type (living versus cadaveric) and the status of stent use (with stent versus without stent) were 5.53% vs. 7.27% (P = 0.064) and 5.24% vs. 20% (P < 0.01) respectively. No recurrence, graft loss or death was seen after these interventions. Comparison of recipients with and without urological complication showed that there was no difference between groups (P > 0.05) with respect to last creatinine level. No graft or patient loss was associated with urological complications. Urological complications that can be surgically corrected should be aggressively treated by experienced surgeons and graft loss avoided.Öğe Effects of caffeic acid phenethyl ester (CAPE) on sepsis in rats(SPRINGER/PLENUM PUBLISHERS, 2008) Tekin, Ahmet; Kuecuekkartallar, Tevfik; Tuerkyilmaz, Serdar; Dinckan, Ayhan; Esen, Hasan; Ates, Burhan; Yilmaz, HueseyinSepsis is still a major cause of the high mortality rate in the intensive care unit. Many studies have been published about the severity of sepsis, but the cause of mortality in sepsis and multiorgan failure is still obscure. This study investigated the effects of caffeic acid phenethyl ester (CAPE) particularly on the inflammatory and related histopathological changes in the lung, liver and kidney in an experimental sepsis model. Forty Sprague Dawley rats were used in this study, and were divided into four groups of ten rats each, as follows: Group I was given intraperitoneal saline infusion treatment. Group II was given intraperitoneal CAPE infusion treatment. Sepsis was induced in the animals in Group III (sepsis with saline infusion), while Group IV rats underwent induced sepsis plus CAPE infusion treatment (sepsis with CAPE infusion). Sampling was performed 48 h after treatment. The induction of sepsis resulted in a significant increase in serum glucose, leukocytes, urea, creatinine, LDH levels in BAL, plasma MDA, AST and ALT levels in the sepsis+saline group. The use of CAPE significantly decreased these parameters. Histopathological examination revealed less congestion, portal inflammation, and focal necrosis of the liver, and less congestion, edema, and emphysematous and inflammatory changes in the lung in the sepsis+CAPE group than in the other groups. These results support that CAPE may be used for the treatment of organ failure during sepsis.Öğe Evaluation of the first 100 liver transplantations(TURKISH SOC GASTROENTEROLOGY, 2008) Dinckan, Ayhan; Tuerkyilmaz, Serdar; Tekin, Ahmet; Duman, Adil; Yilmaz, Aygen; Mesci, Ayhan; Ertug, ZekiBackground/aims: We aimed to present the experience of the first 100 liver transplantations carried out at Akdeniz University. Methods: The data of 100 patients in pediatric and adult age groups who underwent liver transplantation at Akdeniz University Organ Transplantation Center between January 2000 and January 2007 were examined retrospectively. The cases between January 2000 and December 2003 were evaluated as the first term and those between January 2004 and January 2007 as the second term. Results: The mean age of the 100 patients (52M, 48F) was 38.6 +/- 17.3 (1-68) years. One-year and three-year survival rates of the patients were determined as 67.3% and 54.3% in the first term and 88.7% and 79.3% in the second term, respectively. Conclusions: With better comprehension of recipient and donor surgery technique, in addition to accumulation of knowledge and experience, the results in liver transplantation might be improved.Öğe Simultaneous augmentation ileo-cystoplasty in renal transplantation(ELSEVIER SCIENCE INC, 2007) Dinckan, Ayhan; Turkyilmaz, Serdar; Tekin, Ahmet; Erdogru, Tibet; Kocak, Huseyin; Mesci, Ayhan; Gurkan, AlihanINTRODUCTION Renal transplantation is not contraindicated in end-stage renal disease developing as a result of complication of overactive bladder with uninhibited detrusor contractions. As an amendatory Surgical approach, augmentation ileo-cystoplasty is the preferred option to achieve a low intravesical storage pressure. However, the timing of the augmentation ileo-cystoplasty in combination with renal transplantation is still controversial. TECHNICAL CONSIDERATIONS We analyzed data from 3 of the 1100 renal transplantation patients treated at the Akdeniz University Transplantation Center in whom concomitant augmentation ileo-cystoplasty and renal transplantation were performed owing to hypocompliant bladder. CONCLUSIONS The operation times were 360, 270, and 240 minutes. No perioperative major complication or rejection was detected. Bladder augmentation using ileum patch can be concomitantly performed with renal transplantation safety, and this approach avoids the requirement for a second operation in another session.