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Öğe Association of ring box-1 protein overexpression with clinicopathologic prognostic parameters in prostate carcinoma(ELSEVIER SCIENCE INC, 2016) Celik, Zeliha Esin; Kaynar, Mehmet; Dobur, Fatma; Karabagli, Pinar; Goktas, SerdarAim: To determine the expression of Ring Box-1 (RBX-1) protein in prostate carcinoma (PCa) and the association between RBX-1 expression and clinicopathologic prognostic parameters. Material and methods: Relevant data such as age, preoperative serum PSA values, and tumor stage were obtained from 51 patients' with PCa record who underwent radical prostatectomy between January 2010 and March 2014. Hematoxylin-eosin stained pathology slides were evaluated by 2 pathologists blinded to patients' data in order to determine Gleason grade groups, tumor stage, tumor volume, capsule invasion, lymphovascular invasion, perineural invasion, and seminal vesicle invasion Immunoreactivity scoring system (IRS) was used to determine RBX-1 expressions. Results: A statistically significant difference was determined in terms of RBX-1 expression between non tumoral prostate tissue, high grade prostatic intraepithelial neoplasia (H-PIN) and carcinoma foci (P = 0.001). RBX-1 expression in the Gleason pattern 4 was higher than the Gleason pattern 3 and H-PIN foci as well as non tumoral prostate tissue. Likewise, in cases with PSA levels of > 10.1 ng/ml, RBX-1 expression was higher than those <= 10 ng/ml. Moreover, RBX-1 expression of stage II cases was higher than stage I (P = 0.019), RBX-1 expression of stage III higher than stage I cases (P = 0.044). However, RBX-1 expression was not related with clinicopathologic parameters including patient age, tumor volume, lymphovascular invasion, perineural invasion, seminal vesicle invasion, or capsule invasion. Conclusions: RBX-1 protein is overexpressed in PCa and associated with clinicopathologic prognostic parameters related with biological potential of the aggressive disease. Further studies of basic and molecular science are needed to reveal clinical and therapeutic implications of RBX-1 in PCa. (C) 2016 Elsevier Inc. All rights reserved.Öğe Fine needle aspiration biopsy of thyroid nodules: cytologic and histopathologic correlation of 1096 patients(E-CENTURY PUBLISHING CORP, 2015) Ugurluoglu, Ceyhan; Dobur, Fatma; Karabagli, Pinar; Celik, Zeliha EsinVia routinely used thyroid function tests, scintigraphy and ultrasonography (USG), important information is obtained in the clinical and diagnostic practice for thyroid nodules. However, the distinction between benign and malignant lesions cannot precisely be performed with these tests. Thyroid fine needle aspiration biopsy (FNAB) is considered the most reliable diagnostic method in the differentiation between benign and malignant thyroid nodules. It has recently been likely to perform aspiration from deeper nodules via the implemention of FNAB along with USG. Today, in cytopathological examination of thyroid FNAB, standardized Bethesda System for Reporting Thyroid Cytopathology (BSRTC) system is used. Here, FNAB was performed in 1096 patients with thyroid nodules in the Medical School of Selcuk University between January 2009 and July 2014. Patients consisted of 919 women and 177 men between 12 and 87 years of age. Evaluated via BSRTC, the results were classified as unsatisfactory, benign, atypia (or follicular lesions) of undetermined significance (AUS), follicular neoplasm or lesions suspicious for follicular neoplasm (FN), suspected malignant and malignant. After FNAB, 183 patients were operated and evaluated histopathologically. Histological malignancy rates of the categories were as follows: 16% (5), 15% (6) 14% (1) 60% (9), 72% (18) and 97% (63), respectively. In our study, we aimed to compare FNAB results of thyroid nodules with histopathology results after thyroidectomy and to show the sensitivity and specificity of FNAB technique to be higher in the follow-up and diagnosis of thyroid lesions. Given the malignancy detection rate in the follow-up of patients whose cytology was reported as inadequate, we also consider follow-ups are important in these patients.Öğe Mamografilerinde mikrokalsifikasyon saptanan non-palpable lezyonların stereotaktik biyopsilerinin histopatolojik ve radyolojik korelasyonu(Selçuk Üniversitesi Tıp Fakültesi, 2015) Dobur, Fatma; Uğurluoğlu, CeyhanMamografi meme kanserinin kendini gösterme şeklini değiştirmiştir. Meme kanserleri artık daha küçük boyutta, hatta preinvaziv dönemde ve aksiller metastaz yapmadan önce tanı alıp tedavi edilebilmektedir. Görünüm ve kimyasal bileşimine göre iki farklı kalsifikasyon vardır: kalsiyum oksalat (tip1) ve kalsiyum fosfat (tip2). Kalsiyum oksalat prolifere ama non-invaziv meme hastalıklarıyla ilişkiliyken, kalsiyum fosfat benign tümörler ve invaziv malign tümörler ile ilişkili bulunmuştur. Selçuk Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı'nda, mamografisinde mikrokalsifikasyon saptanıp stereotaktik biyopsi yapılan 66 adet non-palpable meme lezyonu değerlendirildi. Histokimyasal Alizarin Red S (pH 4,1-4,3), von Kossa boyaları ve polarize ışık yardımıyla kalsiyum oksalat / kalsiyum fosfat tiplendirmesi yapıldı. Bu iki tip kalsifikasyonun histolojik tanılar -özellikle de mamografik mikrokalsifikasyonların varlığı nedeniyle son zamanlarda saptanmasında artış izlediğimiz "flat epitelyal atipi"- ve 2013'te yenilenen BI-RADS mamografi kategorileri ile ilişkisi saptandı. Çalışmamızda saptanan kalsiyum oksalatların tamamı benign lezyonlarda iken kalsiyum fosfatlar ise hem benign hem malign lezyonlarda izlendi. Benign / malign lezyon ayrımı ile kalsiyum tipi ve mamografik kalsifikasyon morfolojisi arasında anlamlı farklılık saptandı. Tanı ile mamografik kalsifikasyon dağılımı ve BI-RADS kategorileri arasında ise anlamlı ilişki bulunmadı. FEA saptanan biyopsilerin 2'sinde kalsiyum oksalat, 7'sinde kalsiyum fosfat izlendi. Çalışmamızda en sık amorf morfolojide, grup oluşturan ve BI-RADS kategori 4B olarak raporlandı. Sonuç olarak kalsiyum oksalat içeren biyopsilerin benign lehinde değerlendirilebileceği görülmektedir. Son dönemlerde yapılan çalışmalarda non-invaziv olarak, spektrometrik analizler ile kalsiyum tipinin belirlenebilirliği yönündeki bulgular göz önünde bulundurulduğunda hastalara yapılan cerrahi işlemlerin en aza indirgenmesi mümkün görülmektedir.Öğe Myofibroblastic Tumor Seeming Like Schwannoma(DERMAN MEDICAL PUBL, 2015) Oncel, Murat; Sunam, Guven Sadi; Yildiran, Huseyin; Karabagli, Pinar; Dobur, FatmaMyofibroblastic tumors are rarely seen. Radiological imaging have enough information about tumor, but diagnosis is made with histopathologically. For operable intrathoracic tumors, progression is quite good by surgical resection of tumor. In our case, we performed resection via videothoracoscopy as a safe procedure. For inoperable tumors medical treatments are suggested.
